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JACC:类癌性心脏病(CaHD)手术治疗早期和晚期预后(27年结果)

2015-11-10 MedSci MedSci原创

类癌综合征患者的症状和生存率都有所改善,但发展为类癌性心脏病(CaHD)还会继续降低生存率。本研究旨在分析瓣膜手术治疗CaHD后患者在27年的时间中的治疗效果,确定早期和晚期的结果,以提高病人护理。研究人员回顾性研究了在1985年至2012年间在本机构所有连续的CAHD患者接受瓣膜置换的短期和长期结果。研究人员对195例CaHD患者的记录进行了分析。在178例患者中的125例(70%)术前纽约心脏

类癌综合征患者的症状和生存率都有所改善,但发展为类癌性心脏病(CaHD)还会继续降低生存率。

本研究旨在分析瓣膜手术治疗CaHD后患者在27年的时间中的治疗效果,确定早期和晚期的结果,以提高病人护理。

研究人员回顾性研究了在1985年至2012年间在本机构所有连续的CAHD患者接受瓣膜置换的短期和长期结果。

研究人员对195例CaHD患者的记录进行了分析。在178例患者中的125例(70%)术前纽约心脏病协会(NYHA)分级为Ⅲ或IV级。所有患者都进行了三尖瓣置换术(159例瓣膜,36例机械),157例进行了肺动脉瓣手术。其他伴随的手术包括二尖瓣手术(11%)、主动脉瓣手术(9%)、卵圆孔未闭或房间隔缺损闭合(23%)、心脏转移灶切除术或活检(4%)和同期冠状动脉旁路(11% )。有20例围手术期死亡事件(10%);2000年后,围手术期死亡率为6%。幸存率(95%置信区间)在1、5和10年分别为69%(63%至76%),35%(28%至43%),和24%(18%至32%)。总死亡率与年龄较大,细胞毒性化疗和烟草使用有关;75%的幸存者有后续的症状改善。症状前瓣膜手术不与晚期生存利益相关联。

对于CaHD与瓣膜置换手术相关的手术死亡率有所下降。症状和生存的好处是,当CaHD由经验丰富的多学科团队管理时还会产生症状性和生存利益。

原始出处:

Heidi M. Connolly,Hartzell V. Schaff,Martin D. Abel,et al.Early and Late Outcomes of Surgical Treatment in Carcinoid Heart Disease,JACC,2015.11.10

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