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Eur Heart J:戒烟 从不嫌晚

2015-02-12 小田 译 医学论坛网

2月9日在线发表于《欧洲心脏杂志》(Eur Heart J)的一项研究表明,在无已知冠状动脉疾病(CAD)人群中,与从不吸烟者相比,当前吸烟和既往吸烟者的动脉粥样硬化负荷均增加;但仅当前吸烟者的全因死亡或非致命性心肌梗死(MACE)风险升高,而在既往吸烟者中未见到这种升高的风险。 该研究纳入了9456例无已知CAD患者,从不吸烟、当前和既往吸烟者(在行冠脉CT造影之前戒烟≥3个月)分别为

2月9日在线发表于《欧洲心脏杂志》(Eur Heart J)的一项研究表明,在无已知冠状动脉疾病(CAD)人群中,与从不吸烟者相比,当前吸烟和既往吸烟者的动脉粥样硬化负荷均增加;但仅当前吸烟者的全因死亡或非致命性心肌梗死(MACE)风险升高,而在既往吸烟者中未见到这种升高的风险。


该研究纳入了9456例无已知CAD患者,从不吸烟、当前和既往吸烟者(在行冠脉CT造影之前戒烟≥3个月)分别为5685例、1588例和2183例。用Cox比例风险模型校正风险后,评估受试者的吸烟状态和MACE的关系。研究者们进一步对有相似年龄、性别、CAD风险因素和临床表现的受试者评估风险后,按照1:1:1的比例进行倾向匹配。

结果显示,在平均随访的2.8 ± 1.9年期间,共发生了297例MACE事件。与从不吸烟者相比,当前吸烟和既往吸烟者的动脉粥样硬化负荷较重(P< 0.0001),梗阻性CAD发病率较高[单支血管病变(1-VD ):10.6% vs. 14.9% vs. 15.2%,P< 0.001;双支血管病变(2-VD ): 4.4% vs. 6.1% vs. 6.2%,P= 0.001; 3支血管病变(3-VD ): 3.1% vs. 5.2% vs. 4.3%,P< 0.001)]。

与从不吸烟者相比,当前吸烟者的MACE风险更高[风险比(HR)HR1.9,P< 0.001],但在既往吸烟者中却并未观察到的这种升高风险(HR 1.2,P= 0.35)。这种相关性在相匹配人群中也相似。

原始出处:

Nakanishi R1, Berman DS2, Budoff MJ1, Gransar H2, Achenbach S3, Al-Mallah M4, Andreini D5, Cademartiri F6, Callister TQ7, Chang HJ8, Cheng VY9, Chinnaiyan K10, Chow BJ11, Cury R12, Delago A13, Hadamitzky M14, Hausleiter J14, Feuchtner G15, Kim YJ16, Kaufmann PA17, Leipsic J18, Lin FY19, Maffei E6, Pontone G5, Raff G10, Shaw LJ20, Villines TC21, Dunning A22, Min JK23.Current but not past smoking increases the risk of cardiac events: insights from coronary computed tomographic angiography.Eur Heart J. 2015 Feb 8. pii: ehv013. [Epub ahead of print]


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    2015-02-17 chinayinhan

    已阅

    0

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    2015-02-16 windmilL1989

    以阅

    0

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    2015-02-16 jianlion

    是啊

    0

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    2015-02-15 223.104.5.**

    烟,肥胖,百病之源

    0

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    2015-02-14 zhaojie88
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