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JAHA:急性失代偿性心力衰竭患者入院时使用β受体阻滞剂可降低院内死亡率

2021-06-27 MedSci原创 MedSci原创

入院时使用β受体阻滞剂治疗与急性失代偿性心力衰竭患者较低的院内死亡率相关。

入院时使用β受体阻滞剂是否与急性失代偿性心力衰竭患者更好的院内结局相关并未明确。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在评估入院时使用β受体阻滞剂的独立相关因素,以及入院时使用β受体阻滞剂对在京都充血性心力衰竭登记中心注册的3817名急性失代偿性心力衰竭患者的院内死亡率的影响。

入院时有1512名 (39.7%) 因急性失代偿性心力衰竭住院治疗患者接受和2305名 (60.3%) 因急性失代偿性心力衰竭住院治疗患者未接受β受体阻滞剂治疗。与入院时使用β受体阻滞剂独立相关的因素包括既往心力衰竭住院史、心肌梗死病史、心房颤动、心肌病和估计肾小球滤过率<30mL/min/1.73m2。与不使用β受体阻滞剂独立相关的因素包括哮喘、慢性阻塞性肺疾病、较低的体重指数、痴呆、年龄较大和左心室射血分数<40%。

亚组分析结果

接受β受体阻滞剂治疗患者的住院死亡率显著降低(4.4% vs. 7.6%,P<0.001)。即使在调整混杂因素后,入院时使用β受体阻滞剂仍与较低的院内死亡风险显著相关(比值比为0.41;95%CI为0.27-0.60,P<0.001)。此外,入院时使用β受体阻滞剂与较低的心血管死亡风险和较低的非心血管死亡风险显著相关。在接受高剂量β受体阻滞剂治疗的患者中,β受体阻滞剂的使用与较低的院内死亡风险之间的关联相对更为突出。使用β受体阻滞剂治疗对既往心力衰竭住院患者的影响程度大于未住院患者(交互作用P为0.04)。

由此可见,入院时使用β受体阻滞剂治疗与急性失代偿性心力衰竭患者较低的院内死亡率相关

原始出处:

Yodo Tamaki.et al.Lower In‐Hospital Mortality With Beta‐Blocker Use at Admission in Patients With Acute Decompensated Heart Failure.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.020012

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    2021-11-21 zhyy88
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    2021-08-02 ms9000000327937233

    学习了谢谢

    0

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    2021-07-06 361907843

    学习了

    0

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    2021-06-29 zhaohui6731
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    2021-06-27 医鸣惊人

    认真学习了

    0

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