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JCLA:229例外阴阴道念珠菌病患者因念珠菌属表型转换引起的抗真菌敏感性变化

2019-06-01 不详 网络

本研究旨在探讨外阴阴道念珠菌病(VVC)患者表型转换引起的抗真菌敏感性的变化。

本研究旨在探讨外阴阴道念珠菌病(VVC)患者表型转换引起的抗真菌敏感性的变化。

229名女性参与了这项研究。收集患者阴道涂片,革兰氏染色,进行真菌镜检。用氯霉素培养基在沙波洛琼脂上培养棉签阴道分泌物。真菌培养后,用嗜铬琼脂念珠菌显色培养基和鉴定培养基对真菌进行鉴定。然后,采用标准化的CLSI M27A2肉汤微稀释法进行体外抗真菌药敏试验。

VVC患者中64.63%的念珠菌属为白色念珠菌,其余为非白色念珠菌属。在91.22%的白念珠菌感染中观察到表型转换。在抗真菌药敏试验中,白色念珠菌对伏立康唑、氟康唑和伊曲康唑的敏感率明显高于非白色念珠菌(P = 0.00, 0.00, 0.00)。在感染白色念珠菌或非白色念珠菌的患者中,表型切换的临床分离株对氟康唑的易感性显著高于无表型切换的临床分离株(P = 0.01, 0.01)

在本研究中,白色念珠菌是VVC患者中最常见的致病物种,其表型转换容易发生。白念珠菌对所有抗真菌药物的敏感率均高于非白色念珠菌。氟康唑的易感率受白色念珠菌和非白色念珠菌表型转换的影响。

原始出处:

Yuanting Tang, Fan Yu ,The changes of antifungal susceptibilities caused by the phenotypic switching of Candida species in 229 patients with vulvovaginal candidiasis

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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    2020-03-04 amy0563
  5. [GetPortalCommentsPageByObjectIdResponse(id=1721753, encodeId=476a1e217535b, content=<a href='/topic/show?id=95db9e5834b' target=_blank style='color:#2F92EE;'>#阴道念珠菌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97583, encryptionId=95db9e5834b, topicName=阴道念珠菌病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=590b33078144, createdName=yourmama, createdTime=Tue Oct 08 06:01:00 CST 2019, time=2019-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670603, encodeId=941816e06036b, content=<a href='/topic/show?id=c0425209338' target=_blank style='color:#2F92EE;'>#念珠菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52093, encryptionId=c0425209338, topicName=念珠菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3be826737448, createdName=tigerlr107, createdTime=Fri May 15 09:01:00 CST 2020, time=2020-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1946736, encodeId=10e21946e366c, content=<a href='/topic/show?id=e9844301686' target=_blank style='color:#2F92EE;'>#外阴阴道念珠菌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43016, encryptionId=e9844301686, topicName=外阴阴道念珠菌病)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKJUlpK5asKgfVAGEUnO6CbNf6icCfycdBO2zX5TWJq27yt434nFicdjf7OsvbOZBOotQdNx6J6PaZQ/132, createdBy=fcba2500108, createdName=ms6519009802973839, createdTime=Wed Nov 27 15:01:00 CST 2019, time=2019-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775750, encodeId=16d31e75750b7, content=<a href='/topic/show?id=19e45556efa' target=_blank style='color:#2F92EE;'>#抗真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55567, encryptionId=19e45556efa, topicName=抗真菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596c38798743, createdName=amy0563, createdTime=Wed Mar 04 04:01:00 CST 2020, time=2020-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353773, encodeId=d0731353e7393, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jun 03 07:01:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388451, encodeId=2fca138845192, content=<a href='/topic/show?id=7ef25e5346b' target=_blank style='color:#2F92EE;'>#敏感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57534, encryptionId=7ef25e5346b, topicName=敏感性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Mon Jun 03 07:01:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535226, encodeId=acc9153522698, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Mon Jun 03 07:01:00 CST 2019, time=2019-06-03, status=1, ipAttribution=)]
    2019-06-03 zhaojie88
  6. [GetPortalCommentsPageByObjectIdResponse(id=1721753, encodeId=476a1e217535b, content=<a href='/topic/show?id=95db9e5834b' target=_blank style='color:#2F92EE;'>#阴道念珠菌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97583, encryptionId=95db9e5834b, topicName=阴道念珠菌病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=590b33078144, createdName=yourmama, createdTime=Tue Oct 08 06:01:00 CST 2019, time=2019-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670603, encodeId=941816e06036b, content=<a href='/topic/show?id=c0425209338' target=_blank style='color:#2F92EE;'>#念珠菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52093, encryptionId=c0425209338, topicName=念珠菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3be826737448, createdName=tigerlr107, createdTime=Fri May 15 09:01:00 CST 2020, time=2020-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1946736, encodeId=10e21946e366c, content=<a href='/topic/show?id=e9844301686' target=_blank style='color:#2F92EE;'>#外阴阴道念珠菌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43016, encryptionId=e9844301686, topicName=外阴阴道念珠菌病)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKJUlpK5asKgfVAGEUnO6CbNf6icCfycdBO2zX5TWJq27yt434nFicdjf7OsvbOZBOotQdNx6J6PaZQ/132, createdBy=fcba2500108, createdName=ms6519009802973839, createdTime=Wed Nov 27 15:01:00 CST 2019, time=2019-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775750, encodeId=16d31e75750b7, content=<a href='/topic/show?id=19e45556efa' target=_blank style='color:#2F92EE;'>#抗真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55567, encryptionId=19e45556efa, topicName=抗真菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596c38798743, createdName=amy0563, createdTime=Wed Mar 04 04:01:00 CST 2020, time=2020-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353773, encodeId=d0731353e7393, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jun 03 07:01:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388451, encodeId=2fca138845192, content=<a href='/topic/show?id=7ef25e5346b' target=_blank style='color:#2F92EE;'>#敏感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57534, encryptionId=7ef25e5346b, topicName=敏感性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Mon Jun 03 07:01:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535226, encodeId=acc9153522698, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Mon Jun 03 07:01:00 CST 2019, time=2019-06-03, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1721753, encodeId=476a1e217535b, content=<a href='/topic/show?id=95db9e5834b' target=_blank style='color:#2F92EE;'>#阴道念珠菌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97583, encryptionId=95db9e5834b, topicName=阴道念珠菌病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=590b33078144, createdName=yourmama, createdTime=Tue Oct 08 06:01:00 CST 2019, time=2019-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670603, encodeId=941816e06036b, content=<a href='/topic/show?id=c0425209338' target=_blank style='color:#2F92EE;'>#念珠菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52093, encryptionId=c0425209338, topicName=念珠菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3be826737448, createdName=tigerlr107, createdTime=Fri May 15 09:01:00 CST 2020, time=2020-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1946736, encodeId=10e21946e366c, content=<a href='/topic/show?id=e9844301686' target=_blank style='color:#2F92EE;'>#外阴阴道念珠菌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43016, encryptionId=e9844301686, topicName=外阴阴道念珠菌病)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKJUlpK5asKgfVAGEUnO6CbNf6icCfycdBO2zX5TWJq27yt434nFicdjf7OsvbOZBOotQdNx6J6PaZQ/132, createdBy=fcba2500108, createdName=ms6519009802973839, createdTime=Wed Nov 27 15:01:00 CST 2019, time=2019-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775750, encodeId=16d31e75750b7, content=<a href='/topic/show?id=19e45556efa' target=_blank style='color:#2F92EE;'>#抗真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55567, encryptionId=19e45556efa, topicName=抗真菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596c38798743, createdName=amy0563, createdTime=Wed Mar 04 04:01:00 CST 2020, time=2020-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353773, encodeId=d0731353e7393, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jun 03 07:01:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388451, encodeId=2fca138845192, content=<a href='/topic/show?id=7ef25e5346b' target=_blank style='color:#2F92EE;'>#敏感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57534, encryptionId=7ef25e5346b, topicName=敏感性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Mon Jun 03 07:01:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535226, encodeId=acc9153522698, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Mon Jun 03 07:01:00 CST 2019, time=2019-06-03, status=1, ipAttribution=)]
    2019-06-03 tastas
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