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Crit Care:体外循环心肺复苏术治疗院内心脏骤停患者的神经系统结局

2020-08-24 MedSci原创 MedSci原创

院内心脏骤停患者采用ECPR治疗可使大部分患者获得良好的神经功能结局,而患者生存率要高于CCPR文献中所描述的生存率。

院内心脏骤停(IHCA)是主要的不良事件,如果治疗不当,死亡率高。体外心肺复苏(ECPR)作为常规心肺复苏(CCPR)的辅助手段,是一种有前景的IHCA治疗方法。关于ECPR后神经系统结局的证据仍然很少。

近日,危重病医学领域权威杂志Critical Care上发表了一篇研究文章,研究人员对截至2019年12月20日的所有研究进行了全面的系统检索。该研究的主要结局是出院后出现的ECPR后神经系统结局,通过脑功能分类(CPC)评分来衡量。得分为1或2分被定义为有利结局,该研究的次要结局是出院后死亡率。研究人员进行了固定效应的荟萃分析。

研究人员检索获得了1215项结果,其中19项研究被纳入该系统评价中。受试者的平均生存率为30%(95%CI为28-33%,I2=0%,p=0.24)。幸存者获得良好神经系统结局的总百分比为84%(95%CI为80-88%,I2=24%,p=0.90)。

由此可见,院内心脏骤停患者采用ECPR治疗可使大部分患者获得良好的神经功能结局,而患者生存率要高于CCPR文献中所描述的生存率。由于ECPR的适应症可能会拓宽到年龄更大或更虚弱的患者人群,因此,研究应集中在提高患者生存率,同时维持患者获得最佳的神经系统结局。

原始出处:

Benjamin Yaël Gravesteijn.et al.Neurological outcome after extracorporeal cardiopulmonary resuscitation for in-hospital cardiac arrest: a systematic review and meta-analysis.Critical Care.2020.https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-03201-0

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    2020-09-27 aids222
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    2020-08-26 lizhou0204
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    2020-08-24 1474e843m09暂无昵称

    学到了

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    2020-08-24 yhthzx

    学习了

    0

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