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SCI REP：术中芬太尼用量不会影响结直肠癌患者预后

2017-09-08 MedSci MedSci原创

结直肠癌芬太尼预后
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阿片类药物是治疗肿瘤相关疼痛及围手术期急性疼痛的主要止痛药。但是有研究表明阿片类药物会抑制人体细胞及体液免疫功能。尽管目前尚无直接证据证明阿片类在肿瘤发生中的作用，但是动物模型中已发现其可能会导致肿瘤复发。芬太尼也有同样的促肿瘤特性。SCI REP近期发表了一篇文章，研究术中芬太尼用量对结直肠癌患者预后的影响。

阿片类药物是治疗肿瘤相关疼痛及围手术期急性疼痛的主要止痛药。但是有研究表明阿片类药物会抑制人体细胞及体液免疫功能。尽管目前尚无直接证据证明阿片类在肿瘤发生中的作用，但是动物模型中已发现其可能会导致肿瘤复发。芬太尼也有同样的促肿瘤特性。SCI REP近期发表了一篇文章，研究术中芬太尼用量对结直肠癌患者预后的影响。研究共回顾性分析了2011年1月到2014年12月之间共1679例Ⅰ-Ⅲ期接受肿瘤切除的结直肠癌患者。利用风险回归模型分析术后无复发生存和总生存情况。研究结果表明芬太尼用量与无复发生存和总生存之间无剂量依赖联系。通过平均芬太尼用量将患者分为高剂量组和低剂量组，两组间无复发生存和总生存无显着区别。文章最后认为，术中芬太尼用量对结直肠癌患者肿瘤切除后无复发生存或总生存无影响。原始出处：Ying-Hsuan Tai,Hsiang-Ling Wu,et al.Intraoperative Fentanyl Consumption Does Not Impact Cancer Recurrence or Overall Survival after Curative Colorectal

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    2018-08-11 bnurmamat

    #患者预后#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1691925, encodeId=a1bb16919251b, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Sat Aug 11 05:23:00 CST 2018, time=2018-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242636, encodeId=1e00242636e3, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun Sep 10 21:48:10 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1384803, encodeId=a9951384803c0, content=<a href='/topic/show?id=93918690e81' target=_blank style='color:#2F92EE;'>#芬太尼#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86907, encryptionId=93918690e81, topicName=芬太尼)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Sun Sep 10 00:23:00 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452976, encodeId=562914529e668, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun Sep 10 00:23:00 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241727, encodeId=562f241e27ad, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Fri Sep 08 10:27:00 CST 2017, time=2017-09-08, status=1, ipAttribution=)]
    2017-09-10 luominglian113

    学习了.谢谢分享

    0

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    2017-09-10 xue8602

    #芬太尼#

    0

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    2017-09-10 crystal0564

    #结直肠#

    0

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    2017-09-08 戒馋，懒，贪

    谢谢分享.学习了

    0

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