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Medicina :十二指肠原发性胆汁反流对儿童幽门螺杆菌的存在和密度以及儿童胃炎的影响

2020-03-04 不详 网络

尽管很多研究探究了成年患者十二指肠胃反流(DGR)与幽门螺杆菌之间的关系,但研究的结果存在矛盾。另外,在儿童年龄组中,很少有研究研究DGR与幽门螺杆菌之间的关系。在本研究中,我们调查了初级DGR对幽门螺杆菌和胃炎的影响。研究共纳入361例因消化不良而被转诊至我院门诊的患者,均接受了上消化道系统内窥镜检查和胃活检。在45例中检测到DGR,将316例没有DGR的患者视为对照组。根据危险因素(年龄,性别

尽管很多研究探究了成年患者十二指肠反流(DGR)与幽门螺杆菌之间的关系,但研究的结果存在矛盾。另外,在儿童年龄组中,很少有研究研究DGR与幽门螺杆菌之间的关系。在本研究中,我们调查了初级DGR对幽门螺杆菌和炎的影响。

研究共纳入361例因消化不良而被转诊至我院门诊的患者,均接受了上消化道系统内窥镜检查和胃活检。

在45例中检测到DGR,将316例没有DGR的患者视为对照组。根据危险因素(年龄,性别),幽门螺杆菌的存在和密度以及胃炎的存在和严重程度,对DGR病例和对照组进行了比较。纳入研究的患者的平均年龄为11.6±4.6岁。总共128例(36%)是男性,233例(64%)是女性。45例(13%)病例中存在DGR。 DGR患者的平均年龄为13.9±3.1岁,对照组的平均年龄为11.3±4.7,差异有统计学意义(p <0.001)。 DGR与对照组之间在性别方面未发现显著差异(p> 0.05)。在DGR患者中有29例(64%)和对照组的202例(64%)中检测到幽门螺杆菌(+)。幽门螺杆菌患病率之间未发现明显差异(p = 0.947)。在DGR患者中,有37名(82%)和对照组的245名(77%)被检出胃炎(p = 0.476)。幽门螺杆菌的存在和密度,胃炎的存在,严重程度和DGR之间未发现明显差异(p> 0.05)。

总之,该研究结果表明,DGR患者的年龄明显高于对照组,高龄是原发性DGR的危险因素。DGR的存在对幽门螺杆菌的存在和严重程度没有影响。在这种情况下,我们认为根除幽门螺杆菌感染非常重要,尤其是在幽门螺杆菌与DGR一起存在的情况下。

原始出处:

Mehmet Agin, Yusuf Kayar. The Effect of Primary Duodenogastric Bile Reflux on the Presence and Density of Helicobacter pylori and on Gastritis in Childhood. Medicina (Kaunas). 2019 Dec; 55(12): 775. doi: 10.3390/medicina55120775

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    2020-09-06 jeanqiuqiu
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    2020-09-14 kcb069
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    2020-10-23 kalseyzl
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    2020-03-05 feifers
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