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JACC:射血分数的恢复与年轻心梗患者预后的相关性研究

2020-06-10 MedSci原创 MedSci原创

左室射血分数(EF)的恢复与心梗后远期预后的改善呈相关性,然而,年轻心肌梗死患者的长期预后与EF恢复之间的关系尚未被研究。本研究旨在评估年轻时首次心肌梗死患者的左室收缩功能不全的患病率,并比较恢复EF

左室射血分数(EF)的恢复与心梗后远期预后的改善呈相关性,然而,年轻心肌梗死患者的长期预后与EF恢复之间的关系尚未被研究。本研究旨在评估年轻时首次心肌梗死患者的左室收缩功能不全的患病率,并比较恢复EF组与未恢复EF组的预后。

本研究纳入分析了1724名心梗发病年龄≤50岁的患者,主要终点事件是全因和血管死亡率。基线水平时,503名患者的EF<50%,1221名患者的EF正常。与EF正常的患者相比,EF较低的患者更有可能经历ST段抬高型心梗,有较高的肌钙蛋白值,并有更严重的冠状动脉疾病。在基线水平EF值异常的患者中,有216名患者随访期间的EF值可获取,其中90名患者(42%)的EF恢复至50%以上。有EF恢复的患者有较少严重的血管造影疾病,较低的酒精使用量和较低的共病负担。经过平均11.1年时间的随访,EF的恢复与全因死亡率降低8倍和心源性死亡率降低10倍呈相关性。

研究结果显示,有近三分之一的年轻心梗患者患有左室收缩功能不全,其中有40%患者会出现EF恢复,并与更好的预后相关。

原始出处:

Wanda Y et al.Recovery of Left Ventricular Systolic Function and Clinical Outcomes in Young Adults With Myocardial Infarction.JACC.2020 June.

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    2021-05-17 hbwxf
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