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Molecular Metabolism：祖父肥胖的儿孙更易受垃圾食品影响

2016-07-20 徐徐 中国科学报

肥胖垃圾食品
关注

一项

一项在小鼠身上开展的研究表明，肥胖雄性小鼠的“孙子”更容易遭受垃圾食品带来的有害健康影响。相关成果日前发表于《分子新陈代谢》杂志。

此项发现进一步证明，新的性状无须被永久记录在家庭基因中，便可在家族中传递下去。这种现象被称为表观遗传的隔代效应。

去年，一项研究发现，肥胖男性精子中的DNA在数百个位置被修改。同时，这些精子还含有短片段RNA。这些是表观遗传修饰，即它们不影响基因的精确编码，但可能影响特定基因的活性。

如今，来自澳大利亚悉尼张任谦心脏研究所的Catherine Suter及其团队研究了父亲肥胖产生的更长期影响。为此，他们将肥胖的雄性小鼠同瘦小的雌性小鼠交配。

研究发现，当被喂食垃圾食品时，同瘦小的雄性小鼠的后代相比，肥胖雄性小鼠的“儿子”和“孙子”都更有可能表现出脂肪肝疾病和糖尿病的早期迹象。相同的效应未在“女儿”或“孙女”身上看到。

即便是肥胖雄性小鼠的“儿子”被喂以健康饮食并且保持正常体重，它们的“儿子”在接触垃圾食品后，仍有更大的倾向患上同肥胖相关的疾病。不过，这种影响似乎不会传给“曾孙”。“这是好消息，因为它表明，肥胖循环能被打破。”Suter表示。

原始出处

Jennifer E. Cropley1, 2, , 8, , Sally A. Eaton1, 2, 8, Alastair Aiken1, Paul E. Young1, Eleni Giannoulatou1, Joshua W.K. Ho1, 2, Michael E. Buckland3, Simon P. Keam4, Gyorgy Hutvagner4, David T. Humphreys1, Katherine G. Langley5, Darren C. Henstridge5, David I.K. Martin1, 6, Mark A. Febbraio7, Catherine M. Suter1.Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity.Molecular Metabolism.2016

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    2016-09-11 guojianrong

    #Meta#

    0

  2. 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    2016-09-13 维他命

    #垃圾食品#

    0

  3. 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    2016-09-20 1e10c84am36(暂无匿称)

    文章很好，非常有益

    0

  4. 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    2016-09-13 舒心和人

    看来祖上的影响还是很深远的，感谢分享

    0

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    2017-04-10 一闲

    #MET#

    0

  6. 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    2016-07-22 1249859em43(暂无昵称)

    #Metabolism#

    0

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objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zGdN1x8J6HqtUI2Gpibk3sfIIBhZchAhjoiaCQlficdtQTnEqYncy3GVEMPIOJwD7t0mO2KfYGMgkIg/0, createdBy=86081727811, createdName=4546wk, createdTime=Thu Jul 21 00:37:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93814, encodeId=ec589381480, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 13:03:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93815, encodeId=7dca938153b, content=继续关注，, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 13:03:00 CST 2016, time=2016-07-20, status=1, ipAttribution=)]
    2016-07-22 闆锋旦

    #ABO#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1887547, encodeId=8f1e188e54754, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sun Sep 11 16:21:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668386, encodeId=65fa16683863d, content=<a href='/topic/show?id=652641533df' target=_blank style='color:#2F92EE;'>#垃圾食品#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41533, encryptionId=652641533df, topicName=垃圾食品)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a52126287661, createdName=维他命, createdTime=Tue Sep 13 13:21:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131803, encodeId=4a95131803d7, content=文章很好，非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 20 22:38:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125627, encodeId=73ff12562eb8, content=看来祖上的影响还是很深远的，感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zGdN1x8J6HqtUI2Gpibk3sfIIBhZchAhjoiaCQlficdtQTnEqYncy3GVEMPIOJwD7t0mO2KfYGMgkIg/0, createdBy=86081727811, createdName=4546wk, createdTime=Thu Jul 21 00:37:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93814, encodeId=ec589381480, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 13:03:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93815, encodeId=7dca938153b, content=继续关注，, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 13:03:00 CST 2016, time=2016-07-20, status=1, ipAttribution=)]
    2016-07-21 4546wk

    值得一看

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1887547, encodeId=8f1e188e54754, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sun Sep 11 16:21:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668386, encodeId=65fa16683863d, content=<a href='/topic/show?id=652641533df' target=_blank style='color:#2F92EE;'>#垃圾食品#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41533, encryptionId=652641533df, topicName=垃圾食品)], attachment=null, authenticateStatus=null, createdAvatar=null, 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objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zGdN1x8J6HqtUI2Gpibk3sfIIBhZchAhjoiaCQlficdtQTnEqYncy3GVEMPIOJwD7t0mO2KfYGMgkIg/0, createdBy=86081727811, createdName=4546wk, createdTime=Thu Jul 21 00:37:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93814, encodeId=ec589381480, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 13:03:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93815, encodeId=7dca938153b, content=继续关注，, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 13:03:00 CST 2016, time=2016-07-20, status=1, ipAttribution=)]
    2016-07-20 doctorJiangchao

    继续学习

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1887547, encodeId=8f1e188e54754, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sun Sep 11 16:21:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668386, encodeId=65fa16683863d, content=<a href='/topic/show?id=652641533df' target=_blank style='color:#2F92EE;'>#垃圾食品#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41533, encryptionId=652641533df, topicName=垃圾食品)], attachment=null, authenticateStatus=null, createdAvatar=null, 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objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zGdN1x8J6HqtUI2Gpibk3sfIIBhZchAhjoiaCQlficdtQTnEqYncy3GVEMPIOJwD7t0mO2KfYGMgkIg/0, createdBy=86081727811, createdName=4546wk, createdTime=Thu Jul 21 00:37:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93814, encodeId=ec589381480, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 13:03:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93815, encodeId=7dca938153b, content=继续关注，, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 13:03:00 CST 2016, time=2016-07-20, status=1, ipAttribution=)]
    2016-07-20 doctorJiangchao

    继续关注，

    0

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体重过重可能会使你的生活压力变大。科学家说超重的人会比预期早死一年，中度肥胖的人会过早死三年。医生们早就警告说，超重会导致健康并发症包括心脏病，中风和癌症等，先前的研究已经发现，多余的重量会缩短你的寿命，该研究的数据主要是来自欧洲和北美州。在新的研究中，研究人员称这是有史以来最大的分析，研究人员筛选了从1970年到去年的32个国家近400万名不吸烟的成年人的数据。他们将人们的体重指数和死亡的风险进

Lancet：在不同人群中，超重和肥胖都会导致更高的全因死亡率

全世界范围内超重和肥胖人群日益增加。为了评估不同肥胖人群的相关死亡率，我们对BMI相关的前瞻性研究的个体数据进行了meta分析，通过只研究从不吸烟的人群和排除先前存在疾病的人群以及5年的随访时间控制混杂因素和反向因果关系。

早点睡觉降低儿童肥胖风险

俄亥俄州立大学公共卫生学院的研究人员指出，儿科医生和父母应多多关注儿童的入睡时间。研究发表在Pediatrics。 众所周知，肥胖已成为全世界儿童共同面对的重大问题，CDC指出,2-19岁儿童中约17%处于肥胖或超重状态,并增加儿童患慢性疾病如2型糖尿病和心脏病的风险。CDC指出，社会环境对人们的肥胖起不可忽视的影响作用，积极之处在于公益广告呼吁民众改善自身的生活方式，健康饮食的同时积极运动，但是

多喝水可预防体重增加？无稽之谈

民众普遍认为，每天要喝足够的水才对机体健康有益。若机体不能获取足够的水，则机体的许多代谢活动如呼吸、流汗、排尿和排便都不能正常进行。水对机体正常运作十分重要，缺水会导致机体脱水、疲劳,严重者可危及生命。人们对水的需要量取决于体重、年龄和机体活动水平,一般建议成人饮水量为2.7——3.7升。 密歇根大学的新研究表明,BMI更高的民众不建议过多饮水。研究结果发表在the Annals of Famil

Cell Death & Diff：肥胖治疗新靶点

肥胖是一类容易引发多种代谢紊乱疾病（如糖尿病心血管疾病以及脂肪肝等）的慢性疾病。前脂肪细胞（preadipocyte）向脂肪细胞（adipocyte）的转变，即脂肪生成过程，是青少年以及成年人发福的主要原因。在成年人体内，脂肪生成与脂肪细胞的凋亡两者之间的动态平衡使得体重维持在正常水平，尽管如此，人的身体中每年将有10%的脂肪细胞发生替换。因此，脂肪生成过程是肥胖防治的有效靶点。脂肪的生成依赖多步

Lancet：肥胖对男性寿命影响高于女性

一个国际团队１３日在英国《柳叶刀》杂志发表报告说，肥胖与早亡风险（７０岁前死亡）上升相关，其中肥胖男性在这方面的风险要高于肥胖女性。   来自英国、美国、澳大利亚和中国等多国研究人员进行了这项大规模研究。研究人员汇集分析了１９７０年至２０１５年间１８９项研究的数据，涉及来自亚洲、大洋洲、欧洲和北美４个大洲多个国家和地区约３９５万名成年人。研究对象年龄在２０至９０岁之间，都是非吸烟

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