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Diabetes Care:2型糖尿病遗传易感性与心血管并发症相关

2012-11-01 Diabetes Care Diabetes Care

  来自美国马萨诸塞州研究者的一项前瞻性研究表明,2型糖尿病的遗传易感性与2型糖尿病患者心血管并发症的风险增加呈正相关。研究在2012年10月15日在线发表于《糖尿病护理》(Diabetes Care)杂志。   该研究旨在探讨2型糖尿病(T2DM)遗传易感性与2型糖尿病患者心血管疾病(CVD)风险的相关性。研究共纳入健康专业人员随访研究和护士健康研究的1012例男性和1310例女性T

  来自美国马萨诸塞州研究者的一项前瞻性研究表明,2型糖尿病的遗传易感性与2型糖尿病患者心血管并发症的风险增加呈正相关。研究在2012年10月15日在线发表于《糖尿病护理》(Diabetes Care)杂志。

  该研究旨在探讨2型糖尿病(T2DM)遗传易感性与2型糖尿病患者心血管疾病(CVD)风险的相关性。研究共纳入健康专业人员随访研究和护士健康研究的1012例男性和1310例女性T2DM患者,包括677例CVD患者和1645例非CVD对照组受试者。以36个已确定的、独立的易患糖尿病变异基因为基础,计算受试者的遗传倾向评分(GPS)。

  结果表明,GPS中每增加一个糖尿病风险等位基因,即与3%的心血管疾病风险增加相关(比值比[OR]为1.03 [95%CI 1.00-1.06])。与最高四分位数的GPS比较(趋势P值=0.01),心血管疾病风险的OR为1.47(1.11-1.95)。此外,GPS值还与糖化血红蛋白水平呈正相关(P=0.009)。

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    2012-11-14 丁鹏鹏
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