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Eur Ann Allergy Clin Immunol: 过敏性鼻炎和非过敏性鼻炎以及皮肤对金属过敏,它们之间有联系么?

2017-05-18 AlexYang MedSci原创

金属铬、钴、镍与接触性皮炎有关,并且在普通人群中非常普遍,并且,这三种金属在上呼吸道和下呼吸道中还可以作为刺激物。同样,鼻炎(过敏性和非过敏性)是一种高度流行的疾病。鼻炎和皮肤金属过敏疾病可能具有一些相同的炎症机制,但是对金属的皮肤过敏和鼻炎的临床联系从未研究。最近,研究人员评估了皮肤对金属过敏和鼻炎的联系。研究包括患有鼻炎并且经历了标准的诊断程序的病人,包括皮肤试敏鼻内窥镜检查和鼻腔细胞学检查。

金属铬、钴、镍与接触性皮炎有关,并且在普通人群中非常普遍,并且,这三种金属在上呼吸道和下呼吸道中还可以作为刺激物。同样,鼻炎(过敏性和非过敏性)是一种高度流行的疾病。鼻炎和皮肤金属过敏疾病可能具有一些相同的炎症机制,但是对金属的皮肤过敏和鼻炎的临床联系从未研究。最近,研究人员评估了皮肤对金属过敏和鼻炎的联系。研究包括患有鼻炎并且经历了标准的诊断程序的病人,包括皮肤试敏鼻内窥镜检查和鼻腔细胞学检查。研究还包括了健康对照。所参与的所有病人都没有皮肤病,并且所有的参与者都经历了对金属铬、钴、镍的过敏试验。

研究发现,26名对照表现为皮肤点刺试验和鼻腔细胞学检查阳性。而82名鼻炎患者被分为过敏性(组A,27人)、非过敏性(组B,31人)和重叠(组C,24人)三个组。在组A中,阳性皮肤点刺试验的比例为26%,而组B为45%,组C为42%,对照组为31%。研究发现,皮肤点刺阳性比例在组A和组B(p = 0.0045; OR: 0.43)、组A和组C(p = 0.0186; OR: 0.49)、组B和对照(p = 0.0360; OR: 1.85)中都表现为显著不同。另外,在组A+对照和组B+组C中具有显著的差异。最后,研究人员指出,尽管没有皮肤疾病,与过敏性鼻炎和对照比较,对金属的过敏(皮肤点刺试验)的流行程度在非过敏和重叠鼻炎患者中更高。

原始出处:

Gelardi M, Guarino R, Taliente S et al. Allergic and nonallergic rhinitis and skin sensitization to metals: is there a link? Eur Ann Allergy Clin Immunol. May 2017.

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    2017-05-31 linxinjun80

    谢谢

    0

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    2017-05-20 膀胱癌

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