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功能性磁共振（fMRI）研究中任务态的设计要点

2014-06-25 毛清 医学影像教育资讯

功能性磁共振fMRI任务态设计要点
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fMRI简介 1890 年Roy 和Sherrington 研究认为脑血流量的改变与人脑活动有关，同时引发全世界范围脑功能磁共振成像(functional MRI，fMRI) 研究始于1990 年Ogawa 和1991 年Rosen 利用CBV 的变化得到了人脑活动的功能磁共振图像。研究认为生理过程中发生的激动能触动脑皮层整体/ 局部代谢发生连锁式改变，而血氧水平依赖（Blood O

fMRI简介 1890 年Roy 和Sherrington 研究认为脑血流量的改变与人脑活动有关，同时引发全世界范围脑功能磁共振成像(functional MRI，fMRI) 研究始于1990 年Ogawa 和1991 年Rosen 利用CBV 的变化得到了人脑活动的功能磁共振图像。研究认为生理过程中发生的激动能触动脑皮层整体/ 局部代谢发生连锁式改变，而血氧水平依赖（Blood OxygenationLevel Dependent，BOLD）的变化是局部受到神经激动的区域中脱血红蛋白的水平出现极其强烈的瞬时变化；磁共振扫描过程中，血液中的脱氧血红蛋白具有 顺磁性，表现为T2/T2* 值缩短，同时，携带氧原子的氧合血红蛋白具有延长组织T2/T2* 值的反磁性特征；因此血液中氧合血红蛋白与血红蛋白的比例瞬时改变可以明显反应局部脑皮层活动程度的变化；神经元兴奋能引起局部T2 加权像信号增强，反过来就是T2 加权像信号能反映局部神经元的活动，这也就是BOLD 的原理。其实执行刺激任务前后MR 能够检测到BOLD 变化的信号其实十分微弱（只有实际变化的1%~5%，其中还包括了噪声，生理波动，头

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  1. [GetPortalCommentsPageByObjectIdResponse(id=225190, encodeId=fe8522519035, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sat Jul 22 22:43:26 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=64790, encodeId=57fa64e9052, content=想学习啊！·, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnshicSuh3gNicUcydJHgPhNibCQUwrib9mmKXBnPO3hXvic36h1jhh0UlufjTQetvgwTv2JMeyDVH8CQ/132, createdBy=a0ae107008, createdName=Rfreebird, createdTime=Fri Feb 19 17:15:00 CST 2016, time=2016-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37174, encodeId=906d3e174ad, content=国内这么做的地方不多吧？, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f751651970, createdName=fmrilydia, createdTime=Wed Sep 23 03:32:00 CST 2015, time=2015-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915389, encodeId=f639191538936, content=<a href='/topic/show?id=22a1328e7e5' target=_blank style='color:#2F92EE;'>#功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32877, encryptionId=22a1328e7e5, topicName=功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Tue Sep 30 02:27:00 CST 2014, time=2014-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15208, encodeId=51201520882, content=很不错，明天看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=83c11607292, createdName=zzyzzy, createdTime=Fri Feb 06 00:30:00 CST 2015, time=2015-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10201, encodeId=37361020148, content=这个很实用啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=12, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa9590666, createdName=pullo, createdTime=Mon Jun 30 20:42:00 CST 2014, time=2014-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341531, encodeId=ec221341531d3, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Fri Jun 27 04:27:00 CST 2014, time=2014-06-27, status=1, ipAttribution=)]
    2017-07-22 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=225190, encodeId=fe8522519035, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sat Jul 22 22:43:26 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=64790, encodeId=57fa64e9052, content=想学习啊！·, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnshicSuh3gNicUcydJHgPhNibCQUwrib9mmKXBnPO3hXvic36h1jhh0UlufjTQetvgwTv2JMeyDVH8CQ/132, createdBy=a0ae107008, createdName=Rfreebird, createdTime=Fri Feb 19 17:15:00 CST 2016, time=2016-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37174, encodeId=906d3e174ad, content=国内这么做的地方不多吧？, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f751651970, createdName=fmrilydia, createdTime=Wed Sep 23 03:32:00 CST 2015, time=2015-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915389, encodeId=f639191538936, content=<a href='/topic/show?id=22a1328e7e5' target=_blank style='color:#2F92EE;'>#功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32877, encryptionId=22a1328e7e5, topicName=功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Tue Sep 30 02:27:00 CST 2014, time=2014-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15208, encodeId=51201520882, content=很不错，明天看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=83c11607292, createdName=zzyzzy, createdTime=Fri Feb 06 00:30:00 CST 2015, time=2015-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10201, encodeId=37361020148, content=这个很实用啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=12, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa9590666, createdName=pullo, createdTime=Mon Jun 30 20:42:00 CST 2014, time=2014-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341531, encodeId=ec221341531d3, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Fri Jun 27 04:27:00 CST 2014, time=2014-06-27, status=1, ipAttribution=)]
    2016-02-19 Rfreebird

    想学习啊！·

    0

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    2015-09-23 fmrilydia

    国内这么做的地方不多吧？

    0

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    2014-09-30 xlxchina

    #功能性#

    0

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    2015-02-06 zzyzzy

    很不错，明天看看

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=225190, encodeId=fe8522519035, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sat Jul 22 22:43:26 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=64790, encodeId=57fa64e9052, content=想学习啊！·, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnshicSuh3gNicUcydJHgPhNibCQUwrib9mmKXBnPO3hXvic36h1jhh0UlufjTQetvgwTv2JMeyDVH8CQ/132, createdBy=a0ae107008, createdName=Rfreebird, createdTime=Fri Feb 19 17:15:00 CST 2016, time=2016-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37174, encodeId=906d3e174ad, content=国内这么做的地方不多吧？, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f751651970, createdName=fmrilydia, createdTime=Wed Sep 23 03:32:00 CST 2015, time=2015-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915389, encodeId=f639191538936, content=<a href='/topic/show?id=22a1328e7e5' target=_blank style='color:#2F92EE;'>#功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32877, encryptionId=22a1328e7e5, topicName=功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Tue Sep 30 02:27:00 CST 2014, time=2014-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15208, encodeId=51201520882, content=很不错，明天看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=83c11607292, createdName=zzyzzy, createdTime=Fri Feb 06 00:30:00 CST 2015, time=2015-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10201, encodeId=37361020148, content=这个很实用啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=12, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa9590666, createdName=pullo, createdTime=Mon Jun 30 20:42:00 CST 2014, time=2014-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341531, encodeId=ec221341531d3, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Fri Jun 27 04:27:00 CST 2014, time=2014-06-27, status=1, ipAttribution=)]
    2014-06-30 pullo

    这个很实用啊

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=225190, encodeId=fe8522519035, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sat Jul 22 22:43:26 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=64790, encodeId=57fa64e9052, content=想学习啊！·, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnshicSuh3gNicUcydJHgPhNibCQUwrib9mmKXBnPO3hXvic36h1jhh0UlufjTQetvgwTv2JMeyDVH8CQ/132, createdBy=a0ae107008, createdName=Rfreebird, createdTime=Fri Feb 19 17:15:00 CST 2016, time=2016-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37174, encodeId=906d3e174ad, content=国内这么做的地方不多吧？, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f751651970, createdName=fmrilydia, createdTime=Wed Sep 23 03:32:00 CST 2015, time=2015-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915389, encodeId=f639191538936, content=<a href='/topic/show?id=22a1328e7e5' target=_blank style='color:#2F92EE;'>#功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32877, encryptionId=22a1328e7e5, topicName=功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Tue Sep 30 02:27:00 CST 2014, time=2014-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15208, encodeId=51201520882, content=很不错，明天看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=83c11607292, createdName=zzyzzy, createdTime=Fri Feb 06 00:30:00 CST 2015, time=2015-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10201, encodeId=37361020148, content=这个很实用啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=12, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa9590666, createdName=pullo, createdTime=Mon Jun 30 20:42:00 CST 2014, time=2014-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341531, encodeId=ec221341531d3, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Fri Jun 27 04:27:00 CST 2014, time=2014-06-27, status=1, ipAttribution=)]
    2014-06-27 1696533704_45270454

    #磁共振#

    0

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