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Circulation:全新心源性猝死风险模型问世啦

2016-08-24 MedSci MedSci原创

每年有超过30万名美国人发生院外心源性猝死(SCD),这是导致美国民众死亡的主要原因之一。宾夕法尼亚大学佩雷尔曼医学院心血管医学副教授Rajat Deo开发一种新的预测模型来评估既往没有CVD病史的成人出现心源性猝死的风险。研究发表在Circulation。 SCD是指平时没有心脏病史或仅有轻微心脏病症状的人,病情基本稳定,无明显外因、非创伤亦非自伤,由于心电衰竭或机械性衰竭使心脏失去了有效收缩而

每年有超过30万名美国人发生院外心源性猝死(SCD),这是导致美国民众死亡的主要原因之一。宾夕法尼亚大学佩雷尔曼医学院心血管医学副教授Rajat Deo开发一种新的预测模型来评估既往没有CVD病史的成人出现心源性猝死的风险。研究发表在Circulation。 


SCD是指平时没有心脏病史或仅有轻微心脏病症状的人,病情基本稳定,无明显外因、非创伤亦非自伤,由于心脏电衰竭或机械性衰竭使心脏失去了有效收缩而突然死亡发生意外,最常发生于没有心血管疾病史的普通人群。心源性猝死是一个重大公共卫生问题。研究人员指出,制定出特定SCD风险模型仍然十分具有挑战性,因为普通人出现SCD的发生率较低,且普通人群大多需要进行风险得分评估。
 
AHA和ACC为了评估2013年民众患心血管疾病风险设计了一种风险评估方程,这是第一次设计SCD相关性风险评估模型并进行验证。研究人员对17884名成年人进行了调查,他们的年龄均为45岁以上,没有心血管疾病史,且均为ARIC研究和CHS研究这两个大型纵向研究的参与者。研究人员统计和分析了各种人口统计学数据、临床和实验室数据、参与者心电图和超声心动图检查结果,同时抽取了相关血液标本分析生物标记物结果,并收集院外心源性猝死的患者信息。

Deo博士和同事在模型中确认了12种风险标记物的存在。超过了2013年ACC/AHA风险方程中的风险标记物。值得注意的是,左心室射血分数很低,也是风险标记物之一,但由于仅有1/100的患者出现,所以之前并不被重视。

Deo博士指出,他们的研究结果为进一步评估普通民众发作SCD的风险提供了强力的保障,以帮助民众关注自身健康,加强急救意识。

原始出处:

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    2016-09-25 1e10c84am36(暂无匿称)

    文章很好值得关注

    0

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    2016-09-11 1e10c84am36(暂无匿称)

    己拜读,受益匪浅

    0

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    2016-09-07 jyzxjiangqin

    不知道临床意义有多大?

    0

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    2016-09-06 李东泽

    很好,不错,以后会多学习

    0

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    2016-08-29 清河

    终身学习

    0

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    2016-08-28 李东泽

    学习了心源性猝死的新知识。

    0

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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160623/IMG576B1DCFE14EC6883.jpg, createdBy=b21a1740334, createdName=Dr.Ji, createdTime=Sat Aug 27 10:10:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104855, encodeId=198110485500, content=好文章,值得学习,先赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Aug 26 15:29:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457384, encodeId=9899145e38407, content=<a href='/topic/show?id=36ea100885d0' target=_blank style='color:#2F92EE;'>#风险模型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100885, encryptionId=36ea100885d0, topicName=风险模型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=18b75898745, createdName=wjywjy, createdTime=Fri Aug 26 05:54:00 CST 2016, time=2016-08-26, status=1, ipAttribution=)]
    2016-08-27 jyzxjiangqin

    好好学习体会。

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160623/IMG576B1DCFE14EC6883.jpg, createdBy=b21a1740334, createdName=Dr.Ji, createdTime=Sat Aug 27 10:10:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104855, encodeId=198110485500, content=好文章,值得学习,先赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Aug 26 15:29:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457384, encodeId=9899145e38407, content=<a href='/topic/show?id=36ea100885d0' target=_blank 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    2016-08-27 Dr.Ji

    先收藏,心内科医师就是持续学习持续修炼!

    0

  9. 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    2016-08-26 ylzr123

    好文章,值得学习,先赞一个

    0

  10. 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