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Modern Pathology:癌细胞、基质和腔隙组织差异与前列腺癌MRI体内检测能力相关

2019-06-23 AlexYang MedSci原创

最近,有研究人员调查了可能影响前列腺癌多重参数核磁共振成像(MP-MRI)检测能力的组织病理学因素。他们的回顾性研究包括了59名连续性的患者,这些经历了MP-MRI并随后经历个根治性前列腺切除术。这些案例在最后病理学诊断中根据肿瘤大小(10毫米到20毫米)进行了标准化。研究发现,在59个前列腺切除样本中,没有案例具有与大小标准匹配的2个或者以上的癌症病灶位点。在59个病灶部位,35个为MRI可检测

最近,有研究人员调查了可能影响前列腺癌多重参数核磁共振成像(MP-MRI)检测能力的组织病理学因素。

他们的回顾性研究包括了59名连续性的患者,这些经历了MP-MRI并随后经历个根治性前列腺切除术。这些案例在最后病理学诊断中根据肿瘤大小(10毫米到20毫米)进行了标准化。研究发现,在59个前列腺切除样本中,没有案例具有与大小标准匹配的2个或者以上的癌症病灶位点。在59个病灶部位,35个为MRI可检测的(前列腺成像报告和数据系统(PIRADS)得分3分或以上),而24个为MRI不可检测的(PRIRADS得分2分或者更少)。研究人员在MRI可检测组和不可检测组中,在格林森等级分组、格林森模式4比例和格林森模式4优势亚型中没有发现显著差异。从另一方面来讲,与MRI不可检测癌症相比,MRI可检测癌症中癌症细胞平均面积分数显著更高(60.9% vs. 42.7%, P<0.0001),基质平均面积分数(33.8% vs. 45.1%, P=0.00089)和腔体积更低(5.2% vs. 12.2%, P<0.0001)。多变量分析中,癌细胞面积(P=0.0031)和腔体积(P=0.0035)分别表现出了与MRI可检测性强烈的正相关和负相关关系。

最后,研究人员指出,癌症细胞、基质和腔体积的变化,应该考虑作为前列腺癌MRI临床和体内可检测性最好的预测因子之一,而不是传统的组织学参数。

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    2019-11-18 yb6560
  2. [GetPortalCommentsPageByObjectIdResponse(id=1786287, encodeId=edf61e86287e2, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Mon Nov 18 18:26:00 CST 2019, time=2019-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252612, encodeId=b23d12526126b, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Tue Jun 25 04:26:00 CST 2019, time=2019-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368239, encodeId=b7e8368239f2, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43a21971117, createdName=njwbhuang, createdTime=Mon Jun 24 05:58:57 CST 2019, time=2019-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757183, encodeId=bddf1e5718352, content=<a href='/topic/show?id=103b421e0e8' target=_blank style='color:#2F92EE;'>#基质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42170, encryptionId=103b421e0e8, topicName=基质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=281337296540, createdName=ms7899726347904398, createdTime=Tue Apr 14 11:26:00 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040482, encodeId=cde310404827b, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jun 23 16:26:00 CST 2019, time=2019-06-23, status=1, ipAttribution=)]
    2019-06-25 yxch36
  3. [GetPortalCommentsPageByObjectIdResponse(id=1786287, encodeId=edf61e86287e2, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Mon Nov 18 18:26:00 CST 2019, time=2019-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252612, encodeId=b23d12526126b, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Tue Jun 25 04:26:00 CST 2019, time=2019-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368239, encodeId=b7e8368239f2, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43a21971117, createdName=njwbhuang, createdTime=Mon Jun 24 05:58:57 CST 2019, time=2019-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757183, encodeId=bddf1e5718352, content=<a href='/topic/show?id=103b421e0e8' target=_blank style='color:#2F92EE;'>#基质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42170, encryptionId=103b421e0e8, topicName=基质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=281337296540, createdName=ms7899726347904398, createdTime=Tue Apr 14 11:26:00 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040482, encodeId=cde310404827b, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jun 23 16:26:00 CST 2019, time=2019-06-23, status=1, ipAttribution=)]
    2019-06-24 njwbhuang

    好文章!

    0

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    2019-06-23 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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