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BMJ:低出生体重,不健康生活方式增加糖尿病风险

2015-07-25 MedSci译 MedSci原创

 据统计,2014年全球范围内共有糖尿病患者3.87亿,490万人死于糖尿病。2型糖尿病占据了全部糖尿病的85-95%。与遗传上的敏感性一致,不健康的生活方式2型糖尿病的迅速增多有关联。婴幼儿时期的发育和成年后的2型糖尿病风险是有关的。但是,目前鲜有研究探索产前和产后的因素对于糖尿病风险的共同的影响。为了前瞻性地评价出生体重和后天形成的生活方式风险因素与2型糖尿病之间的共同的关系,以及定

据统计,2014年全球范围内共有糖尿病患者3.87亿,490万人死于糖尿病。2型糖尿病占据了全部糖尿病的85-95%。与遗传上的敏感性一致,不健康的生活方式2型糖尿病的迅速增多有关联。婴幼儿时期的发育和成年后的2型糖尿病风险是有关的。但是,目前鲜有研究探索产前和产后的因素对于糖尿病风险的共同的影响。为了前瞻性地评价出生体重和后天形成的生活方式风险因素与2型糖尿病之间的共同的关系,以及定量地分析出生体重、成年后的生活方式和二者相互作用的影响,研究人员进行了一次前瞻性队列研究。

队列包含了149794名在基线时无糖尿病、心血管疾病或者癌症的男性和女性。主要结果是2型糖尿病的发病数,通过自我报道和通过一份补充的问卷确定。不健康的生活方式是基于身体体重指数、吸烟、体育活动、饮酒和交替的健康饮食指数确定的。经过20-30年的跟踪,共有11709例2型糖尿病登记在册。2型糖尿病的多变量校正相对风险为1.45每千克更低体重和2.10每一种不健康生活方式因素。与体重和生活方式相关的2型糖尿病相对风险为2.86,这比与每一个独立因素的风险更高。更低的出生体重对于共同影响的贡献占22%,不健康的生活方式为59%,二者相互作用为18%。这说明出生体重、生活方式与糖尿病的患病风险有关。

这项研究表明,大多数的2型糖尿病可以通过采用更健康的生活方式来进行预防,但是与此同时改善围产期因素可以进一步预防增加的病例。

原始出处:
Yanping Li et al. Birth weight and later life adherence to unhealthy lifestyles in predicting type 2 diabetes: prospective cohort study. BMJ 2015;351:h3673

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    2015-08-06 gaoxiaoe
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    2015-07-28 lyrichen

    0

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