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Neurology:娱乐活动参与度与痴呆症风险

2020-11-03 MedSci原创 MedSci原创

在痴呆症的临床前阶段娱乐活动参与度有所下降。没有强有力的证据表明参加娱乐活动和痴呆之间存在保护性关联。

近日,神经病学领域权威杂志Neurology上发表了一篇研究文章,该研究旨在评估参加娱乐活动与较低痴呆风险相关的假说,在这项平均为期18年的大型纵向研究中,研究人员分析了参加娱乐活动与痴呆事件之间的关系。

研究人员使用了来自白厅II前瞻性队列研究的8280名参与者的数据。包含13个项目的问卷评估了1997–99、2002–04和2007–09年度的参加娱乐活动情况,并从3个国家综合登记册中确定了痴呆发生率(n=360,诊断时平均年龄为76.2岁,发生率=每1000人每年2.4人),且进行随访调查,直至2017年3月。该研究的主要分析基于完整病例(n=6050,病例n=247),通过敏感性分析对缺失的数据进行了多次估算。

平均年龄为55.8岁(1997-99年评估)参加娱乐活动的受试者随访18.0年后,其与痴呆无关(风险比[HR]为0.92,95%CI为0.79-1.06),但平均年龄为65.7岁(2007-09评估)参与程度较高的受试者随访8.3年后发展为痴呆症的可能性较小(HR为0.82 [0.69-0.98])。没有特定类型的娱乐活动与痴呆症风险相关。1997–99年至2007–09年间娱乐活动参与度下降与随后的痴呆症风险相关。

该研究的结果现表明,在痴呆症的临床前阶段娱乐活动参与度有所下降。没有强有力的证据表明参加娱乐活动和痴呆之间存在保护性关联。未来的研究应该调查娱乐活动参与度降低的社会行为、认知和神经生物学驱动因素,以确定改善痴呆症患者社交参与的潜在方法。

原始出处:

Andrew Sommerlad.et al.Leisure activity participation and risk of dementia 18 year follow-up of the Whitehall II Study.Neurology.2020.https://doi.org/10.1212/WNL.0000000000010966

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    2021-06-24 baoya
  2. [GetPortalCommentsPageByObjectIdResponse(id=1913647, encodeId=70e4191364eb6, content=<a href='/topic/show?id=6d3b3e32961' target=_blank style='color:#2F92EE;'>#参与度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37329, encryptionId=6d3b3e32961, topicName=参与度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743d308, createdName=baoya, createdTime=Thu Jun 24 13:35:15 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836240, encodeId=920318362401e, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Wed Nov 04 12:35:15 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001136, encodeId=6ac1200113600, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat May 01 06:35:15 CST 2021, time=2021-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896824, encodeId=2c99896824cc, content=很多问题都是意想不到,可以调查, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b2b82397018, createdName=12346c4dm64暂无昵称, createdTime=Wed Nov 04 11:10:45 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896817, encodeId=64fa89681ede, content=记得看过一篇文献,社交活动也是适度<a href='/topic/show?id=6594e3923bb' target=_blank style='color:#2F92EE;'>#社交活动#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73923, encryptionId=6594e3923bb, topicName=社交活动)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210607/9f00a0de660e4b36b77a9a5f7620d6bf/98c22b17ddf7446fa7b9a618fabcb9f7.jpg, createdBy=a8fb2299762, createdName=Psycho.Dr Du, createdTime=Wed Nov 04 11:05:43 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896766, encodeId=148e896e6662, content=謝謝分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201103/8f4b03f2512742cb8867a5fb4c10e470/23bf7fb239314e82aa20c63be001faea.jpg, createdBy=87735431531, createdName=Ana4000001255913678, createdTime=Wed Nov 04 08:06:03 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048682, encodeId=b2eb104868270, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Wed Nov 04 01:35:15 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896731, encodeId=28d1896e3124, content=非常好的内容!, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201104/9cc489022d2f4a528f7004dd4846f8c9/6d4c395e69f74cd3aa99edb3b3703849.jpg, createdBy=153a5431544, createdName=ms7000001958182561, createdTime=Tue Nov 03 22:45:52 CST 2020, time=2020-11-03, status=1, ipAttribution=)]
    2020-11-04 Boyinsh
  3. [GetPortalCommentsPageByObjectIdResponse(id=1913647, encodeId=70e4191364eb6, content=<a href='/topic/show?id=6d3b3e32961' target=_blank style='color:#2F92EE;'>#参与度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37329, encryptionId=6d3b3e32961, topicName=参与度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743d308, createdName=baoya, createdTime=Thu Jun 24 13:35:15 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836240, encodeId=920318362401e, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Wed Nov 04 12:35:15 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001136, encodeId=6ac1200113600, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat May 01 06:35:15 CST 2021, time=2021-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896824, encodeId=2c99896824cc, content=很多问题都是意想不到,可以调查, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b2b82397018, createdName=12346c4dm64暂无昵称, createdTime=Wed Nov 04 11:10:45 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896817, encodeId=64fa89681ede, content=记得看过一篇文献,社交活动也是适度<a href='/topic/show?id=6594e3923bb' target=_blank style='color:#2F92EE;'>#社交活动#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73923, encryptionId=6594e3923bb, topicName=社交活动)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210607/9f00a0de660e4b36b77a9a5f7620d6bf/98c22b17ddf7446fa7b9a618fabcb9f7.jpg, createdBy=a8fb2299762, createdName=Psycho.Dr Du, createdTime=Wed Nov 04 11:05:43 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896766, encodeId=148e896e6662, content=謝謝分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201103/8f4b03f2512742cb8867a5fb4c10e470/23bf7fb239314e82aa20c63be001faea.jpg, createdBy=87735431531, createdName=Ana4000001255913678, createdTime=Wed Nov 04 08:06:03 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048682, encodeId=b2eb104868270, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Wed Nov 04 01:35:15 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896731, encodeId=28d1896e3124, content=非常好的内容!, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201104/9cc489022d2f4a528f7004dd4846f8c9/6d4c395e69f74cd3aa99edb3b3703849.jpg, createdBy=153a5431544, createdName=ms7000001958182561, createdTime=Tue Nov 03 22:45:52 CST 2020, time=2020-11-03, status=1, ipAttribution=)]
    2021-05-01 yinhl1978
  4. [GetPortalCommentsPageByObjectIdResponse(id=1913647, encodeId=70e4191364eb6, content=<a href='/topic/show?id=6d3b3e32961' target=_blank style='color:#2F92EE;'>#参与度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37329, encryptionId=6d3b3e32961, topicName=参与度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743d308, createdName=baoya, createdTime=Thu Jun 24 13:35:15 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836240, encodeId=920318362401e, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Wed Nov 04 12:35:15 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001136, encodeId=6ac1200113600, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat May 01 06:35:15 CST 2021, time=2021-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896824, encodeId=2c99896824cc, content=很多问题都是意想不到,可以调查, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b2b82397018, createdName=12346c4dm64暂无昵称, createdTime=Wed Nov 04 11:10:45 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896817, encodeId=64fa89681ede, content=记得看过一篇文献,社交活动也是适度<a href='/topic/show?id=6594e3923bb' target=_blank style='color:#2F92EE;'>#社交活动#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73923, encryptionId=6594e3923bb, topicName=社交活动)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210607/9f00a0de660e4b36b77a9a5f7620d6bf/98c22b17ddf7446fa7b9a618fabcb9f7.jpg, createdBy=a8fb2299762, createdName=Psycho.Dr Du, createdTime=Wed Nov 04 11:05:43 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896766, encodeId=148e896e6662, content=謝謝分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201103/8f4b03f2512742cb8867a5fb4c10e470/23bf7fb239314e82aa20c63be001faea.jpg, createdBy=87735431531, createdName=Ana4000001255913678, createdTime=Wed Nov 04 08:06:03 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048682, encodeId=b2eb104868270, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Wed Nov 04 01:35:15 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896731, encodeId=28d1896e3124, content=非常好的内容!, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201104/9cc489022d2f4a528f7004dd4846f8c9/6d4c395e69f74cd3aa99edb3b3703849.jpg, createdBy=153a5431544, createdName=ms7000001958182561, createdTime=Tue Nov 03 22:45:52 CST 2020, time=2020-11-03, status=1, ipAttribution=)]
    2020-11-04 12346c4dm64暂无昵称

    很多问题都是意想不到,可以调查

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1913647, encodeId=70e4191364eb6, content=<a href='/topic/show?id=6d3b3e32961' target=_blank style='color:#2F92EE;'>#参与度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37329, encryptionId=6d3b3e32961, topicName=参与度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743d308, createdName=baoya, createdTime=Thu Jun 24 13:35:15 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836240, encodeId=920318362401e, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Wed Nov 04 12:35:15 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001136, encodeId=6ac1200113600, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat May 01 06:35:15 CST 2021, time=2021-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896824, encodeId=2c99896824cc, content=很多问题都是意想不到,可以调查, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b2b82397018, createdName=12346c4dm64暂无昵称, createdTime=Wed Nov 04 11:10:45 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896817, encodeId=64fa89681ede, content=记得看过一篇文献,社交活动也是适度<a href='/topic/show?id=6594e3923bb' target=_blank style='color:#2F92EE;'>#社交活动#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73923, encryptionId=6594e3923bb, topicName=社交活动)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210607/9f00a0de660e4b36b77a9a5f7620d6bf/98c22b17ddf7446fa7b9a618fabcb9f7.jpg, createdBy=a8fb2299762, createdName=Psycho.Dr Du, createdTime=Wed Nov 04 11:05:43 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896766, encodeId=148e896e6662, content=謝謝分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201103/8f4b03f2512742cb8867a5fb4c10e470/23bf7fb239314e82aa20c63be001faea.jpg, createdBy=87735431531, createdName=Ana4000001255913678, createdTime=Wed Nov 04 08:06:03 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048682, encodeId=b2eb104868270, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Wed Nov 04 01:35:15 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896731, encodeId=28d1896e3124, content=非常好的内容!, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201104/9cc489022d2f4a528f7004dd4846f8c9/6d4c395e69f74cd3aa99edb3b3703849.jpg, createdBy=153a5431544, createdName=ms7000001958182561, createdTime=Tue Nov 03 22:45:52 CST 2020, time=2020-11-03, status=1, ipAttribution=)]
    2020-11-04 Psycho.Dr Du

    记得看过一篇文献,社交活动也是适度#社交活动#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1913647, encodeId=70e4191364eb6, content=<a href='/topic/show?id=6d3b3e32961' target=_blank style='color:#2F92EE;'>#参与度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37329, encryptionId=6d3b3e32961, topicName=参与度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743d308, createdName=baoya, createdTime=Thu Jun 24 13:35:15 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836240, encodeId=920318362401e, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Wed Nov 04 12:35:15 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001136, encodeId=6ac1200113600, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat May 01 06:35:15 CST 2021, time=2021-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896824, encodeId=2c99896824cc, content=很多问题都是意想不到,可以调查, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b2b82397018, createdName=12346c4dm64暂无昵称, createdTime=Wed Nov 04 11:10:45 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896817, encodeId=64fa89681ede, content=记得看过一篇文献,社交活动也是适度<a href='/topic/show?id=6594e3923bb' target=_blank style='color:#2F92EE;'>#社交活动#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73923, encryptionId=6594e3923bb, topicName=社交活动)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210607/9f00a0de660e4b36b77a9a5f7620d6bf/98c22b17ddf7446fa7b9a618fabcb9f7.jpg, createdBy=a8fb2299762, createdName=Psycho.Dr Du, createdTime=Wed Nov 04 11:05:43 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896766, encodeId=148e896e6662, content=謝謝分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201103/8f4b03f2512742cb8867a5fb4c10e470/23bf7fb239314e82aa20c63be001faea.jpg, createdBy=87735431531, createdName=Ana4000001255913678, createdTime=Wed Nov 04 08:06:03 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048682, encodeId=b2eb104868270, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Wed Nov 04 01:35:15 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896731, encodeId=28d1896e3124, content=非常好的内容!, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201104/9cc489022d2f4a528f7004dd4846f8c9/6d4c395e69f74cd3aa99edb3b3703849.jpg, createdBy=153a5431544, createdName=ms7000001958182561, createdTime=Tue Nov 03 22:45:52 CST 2020, time=2020-11-03, status=1, ipAttribution=)]
    2020-11-04 Ana4000001255913678

    謝謝分享

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1913647, encodeId=70e4191364eb6, content=<a href='/topic/show?id=6d3b3e32961' target=_blank style='color:#2F92EE;'>#参与度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37329, encryptionId=6d3b3e32961, topicName=参与度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743d308, createdName=baoya, createdTime=Thu Jun 24 13:35:15 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836240, encodeId=920318362401e, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Wed Nov 04 12:35:15 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001136, encodeId=6ac1200113600, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat May 01 06:35:15 CST 2021, time=2021-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896824, encodeId=2c99896824cc, content=很多问题都是意想不到,可以调查, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b2b82397018, createdName=12346c4dm64暂无昵称, createdTime=Wed Nov 04 11:10:45 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896817, encodeId=64fa89681ede, content=记得看过一篇文献,社交活动也是适度<a href='/topic/show?id=6594e3923bb' target=_blank style='color:#2F92EE;'>#社交活动#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73923, encryptionId=6594e3923bb, topicName=社交活动)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210607/9f00a0de660e4b36b77a9a5f7620d6bf/98c22b17ddf7446fa7b9a618fabcb9f7.jpg, createdBy=a8fb2299762, createdName=Psycho.Dr Du, createdTime=Wed Nov 04 11:05:43 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896766, encodeId=148e896e6662, content=謝謝分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201103/8f4b03f2512742cb8867a5fb4c10e470/23bf7fb239314e82aa20c63be001faea.jpg, createdBy=87735431531, createdName=Ana4000001255913678, createdTime=Wed Nov 04 08:06:03 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048682, encodeId=b2eb104868270, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Wed Nov 04 01:35:15 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896731, encodeId=28d1896e3124, content=非常好的内容!, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201104/9cc489022d2f4a528f7004dd4846f8c9/6d4c395e69f74cd3aa99edb3b3703849.jpg, createdBy=153a5431544, createdName=ms7000001958182561, createdTime=Tue Nov 03 22:45:52 CST 2020, time=2020-11-03, status=1, ipAttribution=)]
    2020-11-04 junJUN

    老年人痴呆何药可用??

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1913647, encodeId=70e4191364eb6, content=<a href='/topic/show?id=6d3b3e32961' target=_blank style='color:#2F92EE;'>#参与度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37329, encryptionId=6d3b3e32961, topicName=参与度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743d308, createdName=baoya, createdTime=Thu Jun 24 13:35:15 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836240, encodeId=920318362401e, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Wed Nov 04 12:35:15 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001136, encodeId=6ac1200113600, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat May 01 06:35:15 CST 2021, time=2021-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896824, encodeId=2c99896824cc, content=很多问题都是意想不到,可以调查, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b2b82397018, createdName=12346c4dm64暂无昵称, createdTime=Wed Nov 04 11:10:45 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896817, encodeId=64fa89681ede, content=记得看过一篇文献,社交活动也是适度<a href='/topic/show?id=6594e3923bb' target=_blank style='color:#2F92EE;'>#社交活动#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73923, encryptionId=6594e3923bb, topicName=社交活动)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210607/9f00a0de660e4b36b77a9a5f7620d6bf/98c22b17ddf7446fa7b9a618fabcb9f7.jpg, createdBy=a8fb2299762, createdName=Psycho.Dr Du, createdTime=Wed Nov 04 11:05:43 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896766, encodeId=148e896e6662, content=謝謝分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201103/8f4b03f2512742cb8867a5fb4c10e470/23bf7fb239314e82aa20c63be001faea.jpg, createdBy=87735431531, createdName=Ana4000001255913678, createdTime=Wed Nov 04 08:06:03 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048682, encodeId=b2eb104868270, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Wed Nov 04 01:35:15 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896731, encodeId=28d1896e3124, content=非常好的内容!, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201104/9cc489022d2f4a528f7004dd4846f8c9/6d4c395e69f74cd3aa99edb3b3703849.jpg, createdBy=153a5431544, createdName=ms7000001958182561, createdTime=Tue Nov 03 22:45:52 CST 2020, time=2020-11-03, status=1, ipAttribution=)]
    2020-11-03 ms7000001958182561

    非常好的内容!

    0

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