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Science & MBE:全基因组测序帮助追踪真菌特殊降解酶类的起源

2016-05-08 佚名 生物谷

图片来源:www.phys.org 近日,发表在国际杂志Molecular Biology and Evolution上的一项研究论文中,来自美国能源部联合基因组研究所等机构的研究人员通过对10株白腐真菌和褐腐真菌进行全基因组测序阐明了真菌中和木质纤维素分解相关的酶类起源的时间轴。 真菌是植物体的天然降解帮手,其包含有特殊的酶类可以帮助科学家从事很多应用性研究。对白腐真菌和褐腐真菌进行全基

图片来源:www.phys.org

近日,发表在国际杂志Molecular Biology and Evolution上的一项研究论文中,来自美国能源部联合基因组研究所等机构的研究人员通过对10株白腐真菌和褐腐真菌进行全基因组测序阐明了真菌中和木质纤维素分解相关的酶类起源的时间轴。

真菌是植物体的天然降解帮手,其包含有特殊的酶类可以帮助科学家从事很多应用性研究。对白腐真菌和褐腐真菌进行全基因组测序研究其酶类家族填补了研究者们长期以来在真菌进化领域研究的空白,同时也提供了更加精确的时间轴来揭示可以在不同时间段对植物体进行降解的关键真菌。

生物能源的研究人员一直以来都非常感兴趣从事朽木菌的研究,因为朽木菌所产生的酶类可以降解多种植物原材料,比如纤维素、半纤维素和木质素等,褐腐真菌被认为仅可以降解纤维素和半纤维素,而白腐真菌则可以降解所有的植物体组分,比如纤维素等。对真菌基因组的大范围测序或许就可以帮助研究者们制定更为深入的真菌降解朽木的策略;文章中研究人员构建了一种比较基因组学的分析技术来帮助进行10株真菌的测序,组装以及信息注解,这样一来就可以更好地追溯真菌木质素降解关键酶类的起源了。

早在2012年研究人员就在Science杂志上刊文表示,3亿年前白腐真菌的进化正好与成煤石炭纪的结束同时进行,而这就影响到了地球的碳循环;该研究中研究者并没有对早期分化的真菌进行全基因组的测序研究。而本文研究中研究人员进行了大量的测序研究揭示了真菌关键降解酶类的起源问题,为后期生物能源学家们有效利用真菌的降解特性来从事更多深入的研究,同时鉴别新型的降解酶类提供了新的线索。.

原始出处:

Dimitrios Floudas1, Manfred Binder1, Robert Riley2, Kerrie Barry2,et,al.The Paleozoic Origin of Enzymatic Lignin Decomposition Reconstructed from 31 Fungal Genomes.Science.doi:10.1126/science.1221748

László G. Nagy*,1, Robert Riley2, Andrew Tritt2,,et,al.Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides Insights into the Origins of Lignocellulose Decay Capabilities.Molecular Biology and Evolution.doi:10.1093/molbev/msv337

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    2016-05-10 zhaojie88
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    2016-05-10 jichang
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    2016-05-09 jaysppr

    肠道菌群现在火热啊

    0

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