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BMJ:社区获得性肺炎(CAP)患者入院时血糖水平高,预示死亡风险增加

2012-06-17 刘伟杰 编译 中国医学论坛报

Fig 1Cumulative incidence of death (%) within 90 days in participants with community acquired pneumonia stratified by serum glucose levels on admission overall (n=6016) (top) and without diabetes (n=5

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Fig 1 Cumulative incidence of death (%) within 90 days in participants with community acquired pneumonia stratified by serum glucose levels on admission overall (n=6016) (top) and without diabetes (n=5141) (bottom). The 875 participants with missing data for serum glucose levels on admission were not included in these calculations for patients at risk

  一项多国联合研究显示,既往无糖尿病,但入院时有急性高血糖症的社区获得性肺炎(CAP)患者面临更高的死亡风险。论文5月29日在线发表于《英国医学杂志》(BMJ)。

  研究者共收集了2003年~2009年间来自德国、瑞士和奥地利的6891例CAP患者数据,在校正性别、年龄、当前吸烟状况、CAP严重程度及各种共病因素后,评估了入院时不同血糖水平与患者28、90和180天死亡率的相关性。

  结果为,既往无糖尿病但入院时血糖水平升高,是CAP患者28天和90天内死亡的预测因子。与入院时血糖水平正常者相比,存在轻度急性高血糖症者(血糖水平6~10.99 mmol/L)90天内死亡风险显著增加[危险比(HR)=1.56,P<0.001],当患者入院时血糖水平≥14 mmol/L时,90天内死亡风险也随之进一步升高(HR=2.37,P<0.001)。此外,与无糖尿病患者相比,既往患糖尿病者总体死亡率显著升高(HR=2.47,P<0.001)。这一结果不受入院时患者血糖水平的影响(P=0.18)。

原始文献:

Lepper PM, Ott S, Nüesch E, von Eynatten M, Schumann C, Pletz MW, Mealing NM, Welte T, Bauer TT, Suttorp N, Jüni P, Bals R, Rohde G; on behalf of the German Community Acquired Pneumonia Competence Network (CAPNETZ).Serum glucose levels for predicting death in patients admitted to hospital for community acquired pneumonia: prospective cohort study. BMJ. 2012 May 28;344:e3397. doi: 10.1136/bmj.e3397.

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    2013-03-30 smlt2008
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    2013-01-22 gaoxiaoe
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