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Abametapir洗剂,只需10分钟,即可治疗头虱!

2016-10-26 MedSci MedSci原创

根据在2016 AAP全国会议及展览海报介绍中显示:Abametapir,一个新的金属蛋白酶抑制剂,使用10分钟后,可完全抑制虱子的卵孵化蛋。“目前对于头虱的治疗还不能完全杀卵活性,需要治疗7至10天才能消除所有孵出的虱子,”Hatchtech控股有限公司卵细胞研究的首席科学官兼董事Vern Bowles博士说:“此外,抗多种神经毒性的产品越来越多,让很多产品对‘超级虱子’是无效的。”“Abame

根据在2016 AAP全国会议及展览海报介绍中显示:Abametapir,一个新的金属蛋白酶抑制剂,使用10分钟后,可完全抑制虱子的卵孵化蛋。

“目前对于头虱的治疗还不能完全杀卵活性,需要治疗7至10天才能消除所有孵出的虱子,”Hatchtech控股有限公司卵细胞研究的首席科学官兼董事Vern Bowles博士说:“此外,抗多种神经毒性的产品越来越多,让很多产品对‘超级虱子’是无效的。”

“Abametapir洗剂,0.74%,是一种新开发的产品,具有新作用机制,可影响虱子蛋发展和生存的关键因子。”他说。

为确定Abametapir洗剂对抑制头虱卵的有效性,Bowles和同事进行了一项双盲单剂量研究,纳入50例3-17岁、活跃头虱侵袭的患者,随机接受abametapir, 0.74%或媒介物治疗。在应用前从实验组中取出卵作为对照组。

患者随机接受abametapir洗剂或媒介物治疗10分钟,所有患者用温水冲洗头发。研究人员将未孵化的卵在30摄氏度的环境中孵化14天,与预处理和后处理的孵化卵进行比较。

与对照组相比,在abametapir洗剂治疗的患者中,100%的卵仍然未孵化和孵化的还原率为92.9%(95% CI,86.5-99.4)。媒介物治疗的患者中,64%的卵仍然未孵化和孵化的还原率为42.3% (95% CI, 30.2-54.4)。

此外,在1天和7天的随访中,abametapir组有22例是无虱的,对照组有8例。

Bowles说:“在临床试验中,abametapir洗剂,0.74 %,可有效治疗头虱,使用一次即可,仅需10分钟。”

原始出处:

Bowles VM, Yoon KS, Barker SC, Tran C, Rhodes C, Clark MJ. Ovicidal Efficacy of Abametapir Against Eggs of Human Head and Body Lice (Anoplura: Pediculidae). J Med Entomol. 2016 Aug 21. pii: tjw132.

Single-application treatment shows efficacy in head lice egg elimination.Healio.October 25, 2016

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1887578, encodeId=c10d188e578ee, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue Jan 03 01:14:00 CST 2017, time=2017-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895967, encodeId=fcee189596e47, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun Apr 02 01:14:00 CST 2017, time=2017-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155015, encodeId=4382155015e1, content=讲的好,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Nov 11 13:21:11 CST 2016, time=2016-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151475, encodeId=de911514e59a, content=有意思,,,现在还有这个东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Thu Oct 27 09:26:08 CST 2016, time=2016-10-27, status=1, ipAttribution=)]
    2017-01-03 guojianrong
  2. [GetPortalCommentsPageByObjectIdResponse(id=1887578, encodeId=c10d188e578ee, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue Jan 03 01:14:00 CST 2017, time=2017-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895967, encodeId=fcee189596e47, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun Apr 02 01:14:00 CST 2017, time=2017-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155015, encodeId=4382155015e1, content=讲的好,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Nov 11 13:21:11 CST 2016, time=2016-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151475, encodeId=de911514e59a, content=有意思,,,现在还有这个东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Thu Oct 27 09:26:08 CST 2016, time=2016-10-27, status=1, ipAttribution=)]
    2017-04-02 一闲
  3. [GetPortalCommentsPageByObjectIdResponse(id=1887578, encodeId=c10d188e578ee, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue Jan 03 01:14:00 CST 2017, time=2017-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895967, encodeId=fcee189596e47, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun Apr 02 01:14:00 CST 2017, time=2017-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155015, encodeId=4382155015e1, content=讲的好,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Nov 11 13:21:11 CST 2016, time=2016-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151475, encodeId=de911514e59a, content=有意思,,,现在还有这个东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Thu Oct 27 09:26:08 CST 2016, time=2016-10-27, status=1, ipAttribution=)]
    2016-11-11 虈亣靌

    讲的好,学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1887578, encodeId=c10d188e578ee, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue Jan 03 01:14:00 CST 2017, time=2017-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895967, encodeId=fcee189596e47, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun Apr 02 01:14:00 CST 2017, time=2017-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155015, encodeId=4382155015e1, content=讲的好,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Nov 11 13:21:11 CST 2016, time=2016-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151475, encodeId=de911514e59a, content=有意思,,,现在还有这个东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Thu Oct 27 09:26:08 CST 2016, time=2016-10-27, status=1, ipAttribution=)]
    2016-10-27 䖝二

    有意思,,,现在还有这个东西

    0

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