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JAHA:急性冠脉综合征患者贫血会增加死亡风险

2016-11-26 haofan MedSci原创

在当代国家ACS队列中,贫血的患病率具有重要的临床意义。伴有贫血的ACS患者年龄较大、伴有多个疾病以较少可能的接受能够改善临床预后的寻证治疗,而且贫血与死亡率存在独立的相关性。

近日,心血管病领域权威杂志JAHA上发表了来自英国阿伯丁大学应用健康科学所诺维奇市心血管研究组的Phyo K. Myint教授及其研究团队的文章,旨在明确急性冠状动脉综合征(ACS)患者贫血的发生率,并与未进行选择的国家ACS队列中无贫血对照者来进行比较,以确定其临床特点、治疗管理和临床预后。

研究人员通过心肌缺血国家审计项目(MINAP)登记处收集所有在英格兰和威尔士因诊断为ACS而住院成年人的临床数据。在这项回顾性队列研究中,研究人员通过分析于2006年1月至2010年12月期间在这个登记处进行注册并随访至2011年8月的患者。


研究者采用多因素Logistic回归分析来确定贫血的相关因素、血红蛋白增加1g/dL后30天内死亡率的调整后比值比,以及相比于无贫血者,贫血者30天和1年死亡率,在分析之前对协变量进行了调整。

研究人员的分析结果表明,在422,855例ACS患者中有27.7%的患者存在贫血,并且这些患者年龄较大,肾脏疾病、周围血管疾病、糖尿病患病率也较高,以往有急性心肌梗死病史,而且较少可能接受能够改善临床预后的寻证治疗。

最后,研究人员的分析结果表明,贫血与ACS患者30天死亡率(比值比为1.28,95%可信区间为1.22‐1.35)和1年死亡率(比值比为1.31,95%可信区间为1.27‐1.35)独立相关,并且在血红蛋白水平与死亡率结局之间可以观察到一个反J形关系。

因此,在ACS队列中,贫血的患病率具有重要的临床意义。伴有贫血的ACS患者年龄较大、伴有多种疾病以及较少可能接受能够改善临床预后的寻证治疗,而且贫血与死亡率存在独立的相关性。


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    2016-12-04 Jackie Li

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    2016-11-28 zhaohui6731
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