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BMJ:降脂治疗可减少老年人卒中发生率达30%

2015-06-04 小田 译 医学论坛网

法国学者在无已知血管事件的老年人中研究了降脂药物(他汀或贝特类)与冠心病和卒中长期风险的关系,结果表明,他汀或贝特类药物可减少上述人群30%的卒中发生率。相关论文5月19日在线发表于《英国医学杂志》(简称BMJ)杂志。研究者们随机纳入了居住在法国3个城市社区人群7484例,年龄≥65岁(平均年龄73.9岁),女性占63%,入组时受试者均无无已知血管事

法国学者在无已知血管事件的老年人中研究了降脂药物(他汀或贝特类)与冠心病和卒中长期风险的关系,结果表明,他汀或贝特类药物可减少上述人群30%的卒中发生率。相关论文5月19日在线发表于《英国医学杂志》(简称BMJ)杂志。

研究者们随机纳入了居住在法国3个城市社区人群7484例,年龄≥65岁(平均年龄73.9岁),女性占63%,入组时受试者均无无已知血管事件病史。平均随访9.1年。利用多变量Cox比例风险模型校正许多潜在混淆因素后,计算基线时用降脂药和未用降脂药受试者的冠心病和卒中校正危险比(HR)。分别评估使用任意降脂药(他汀和贝特类)的危险比。

结果显示,与未使用降脂药受试者相比。使用降脂药的受试者卒中风险减少(HR0.66,95%置信区间0.49~0.90);他汀和贝特类药物使用者的卒中HR相似,分别为(0.68,0.45~1.01)和(0.66,0.44 ~ 0.98)。降脂药的使用和冠心病无关(HR 1.12,0.90~1.40)。

基于年龄、性别、体质指数、高血压、收缩压、甘油三酯浓度和倾向评分的分层分析显示,这些变量对卒中或冠心病无任何修正作用。

原始出处:

Annick Alpérovitch, emeritus director of research12, Tobias Kurth, director of research12, Marion Bertrand, biostatistician12, Marie-Laure Ancelin, director of research34, Catherine Helmer, researcher12, Stéphanie Debette, professor12, Christophe Tzourio, professor12.Primary prevention with lipid lowering drugs and long term risk of vascular events in older people: population based cohort study.BMJ, May 19, 2015.doi: http://dx.doi.org/10.1136/bmj.h2335

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1826277, encodeId=067518262e72b, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Jun 29 05:12:00 CST 2015, time=2015-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847677, encodeId=4989184e677cf, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Feb 04 18:12:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28819, encodeId=dd022881917, content=血压血脂血糖重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Thu Jun 25 09:41:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26006, encodeId=30432600613, content=高脂饮食真是有害健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Thu Jun 04 18:46:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25961, encodeId=572b2596154, content=百分之三十的减少其实这真的变量以后很难说你要这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Thu Jun 04 17:08:00 CST 2015, time=2015-06-04, status=1, ipAttribution=)]
    2016-02-04 gaoxiaoe
  3. [GetPortalCommentsPageByObjectIdResponse(id=1826277, encodeId=067518262e72b, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Jun 29 05:12:00 CST 2015, time=2015-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847677, encodeId=4989184e677cf, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Feb 04 18:12:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28819, encodeId=dd022881917, content=血压血脂血糖重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Thu Jun 25 09:41:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26006, encodeId=30432600613, content=高脂饮食真是有害健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Thu Jun 04 18:46:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25961, encodeId=572b2596154, content=百分之三十的减少其实这真的变量以后很难说你要这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Thu Jun 04 17:08:00 CST 2015, time=2015-06-04, status=1, ipAttribution=)]
    2015-06-25 nizongzan

    血压血脂血糖重要

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1826277, encodeId=067518262e72b, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Jun 29 05:12:00 CST 2015, time=2015-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847677, encodeId=4989184e677cf, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Feb 04 18:12:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28819, encodeId=dd022881917, content=血压血脂血糖重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Thu Jun 25 09:41:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26006, encodeId=30432600613, content=高脂饮食真是有害健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Thu Jun 04 18:46:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25961, encodeId=572b2596154, content=百分之三十的减少其实这真的变量以后很难说你要这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Thu Jun 04 17:08:00 CST 2015, time=2015-06-04, status=1, ipAttribution=)]
    2015-06-04 s312486

    高脂饮食真是有害健康

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1826277, encodeId=067518262e72b, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Jun 29 05:12:00 CST 2015, time=2015-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847677, encodeId=4989184e677cf, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Feb 04 18:12:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28819, encodeId=dd022881917, content=血压血脂血糖重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Thu Jun 25 09:41:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26006, encodeId=30432600613, content=高脂饮食真是有害健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Thu Jun 04 18:46:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25961, encodeId=572b2596154, content=百分之三十的减少其实这真的变量以后很难说你要这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Thu Jun 04 17:08:00 CST 2015, time=2015-06-04, status=1, ipAttribution=)]
    2015-06-04 medcardio

    百分之三十的减少其实这真的变量以后很难说你要这个

    0

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