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Am J Clin Nutr:维生素C和绝经后乳腺癌风险有什么关系

2016-05-23 Seven L 译 MedSci原创

维生素C摄入量和乳腺癌风险之间的关系,在实验和流行病学研究中取得了相互矛盾的结果。因此研究者进行了一项研究,探究维生素C的摄入量和乳腺癌风险之间的关系,同时将膳食维生素C的摄入量考虑在内。1995-2008年期间,该研究共纳入了57,403名绝经后妇女,在随访的581,085人年期间,共发生了2482例浸润性乳腺癌。在1993-1995年,通过食物频率问卷调查获取参与者的膳食维生素C摄入情况,并在

维生素C摄入量和乳腺癌风险之间的关系,在实验和流行病学研究中取得了相互矛盾的结果。因此研究者进行了一项研究,探究维生素C的摄入量和乳腺癌风险之间的关系,同时将膳食维生素C的摄入量考虑在内。

1995-2008年期间,该研究共纳入了57,403名绝经后妇女,在随访的581,085人年期间,共发生了2482例浸润性乳腺癌。在1993-1995年,通过食物频率问卷调查获取参与者的膳食维生素C摄入情况,并在1995年、2000年、2002年和2005年通过问卷调查获取参与者维生素C补充剂的使用情况。

研究结果显示,维生素C补充剂的使用与整体乳腺癌风险是不相关的,但是膳食维生素C摄入最高的四分位数女性,维生素C补充剂会增加其乳腺癌风险(HR: 1.32; 95% CI: 1.04, 1.67),不过对于其他膳食维生素C摄入量的女性,两者之间不相关(交互P=0.03)。

研究结果表明,只有膳食维生素C高摄入女性,维生素C补充剂的使用才与绝经后乳腺癌风险的增加有关。同时数据也支持,总维生素C摄入量与绝经后乳腺癌的风险之间可能存在潜在的U型或J型关系,值得进一步研究。

原始出处:

Cadeau C, Fournier A,et al.Vitamin C supplement intake and postmenopausal breast cancer risk: interaction with dietary vitamin C.Am J Clin Nutr. 2016 May 18. pii: ajcn126326. [Epub ahead of print]


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    2016-07-25 sjq027
  2. [GetPortalCommentsPageByObjectIdResponse(id=2061531, encodeId=d006206153196, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Mon Jul 25 15:12:00 CST 2016, time=2016-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138119, encodeId=fe75138119b1, content=拜读,好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 15:15:19 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=109841, encodeId=9f2c1098411c, content=学习了,希望继续研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Fri Sep 02 19:12:00 CST 2016, time=2016-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1770250, encodeId=34511e702509e, content=<a href='/topic/show?id=df9c23e868a' target=_blank style='color:#2F92EE;'>#乳腺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23786, encryptionId=df9c23e868a, topicName=乳腺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9538161180, createdName=gaoxiaoe, createdTime=Thu Dec 29 09:12:00 CST 2016, time=2016-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87303, encodeId=10878e303b9, content=哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/12/07/86eb8ff0cc5e04d9b292a27c2970a0be.jpg, createdBy=73691616008, createdName=text, createdTime=Fri May 27 10:48:00 CST 2016, time=2016-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257050, encodeId=0d13125e05059, content=<a href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Wed May 25 01:12:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631515, encodeId=d08716315156b, content=<a href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Wed May 25 01:12:00 CST 2016, time=2016-05-25, status=1, ipAttribution=)]
    2016-09-30 1e10c84am36(暂无匿称)

    拜读,好文

    0

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    2016-09-02 明崖

    学习了,希望继续研究

    0

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    2016-05-27 text

    哈哈

    0

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    2016-05-25 zxxiang

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