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Am J Rhinol Allergy:鼻腔细胞学作为局部过敏性鼻炎的诊断工具分析

2019-06-07 AlexYang MedSci原创

局部过敏性鼻炎(LAR)可以通过皮刺试验(SPT)或者特异性血清lgE水平进行评估,具体表现为慢性鼻炎对过敏原的局部鼻过敏响应,且不存在全身免疫球蛋白(lgE)调控的疾病。鼻激发试验(NPT)是LAR诊断的黄金标准。鼻嗜酸性粒细胞是一种已知的过敏性鼻炎炎症标记。最近,有研究人员认为鼻嗜酸性粒细胞可以作为LAR的一种筛选标记并进行了验证。研究包括了48名具有常年非过敏性鼻炎(NAR)患者,且SPT为

局部过敏性鼻炎(LAR)可以通过皮刺试验(SPT)或者特异性血清lgE水平进行评估,具体表现为慢性鼻炎对过敏原的局部鼻过敏响应,且不存在全身免疫球蛋白(lgE)调控的疾病。鼻激发试验(NPT)是LAR诊断的黄金标准。鼻嗜酸性粒细胞是一种已知的过敏性鼻炎炎症标记。最近,有研究人员认为鼻嗜酸性粒细胞可以作为LAR的一种筛选标记并进行了验证。

研究包括了48名具有常年非过敏性鼻炎(NAR)患者,且SPT为阴性,并进行了鼻细胞学检查。研究人员利用3种过敏原(混合螨虫、混合蟑螂和百慕大草),并利用NPT对LAR进行了诊断。鼻症状组合鼻腔开放用来对NPT结果进行评估。另外,研究人员评估了鼻嗜酸性粒细胞的敏感性、特异性和阳性以及阴性预测值作为LAR诊断工具的情况。研究发现,LAR在41.6%的患者中诊出。鼻嗜酸性粒细胞在58%的NAR患者中发现。鼻嗜酸性粒细胞诊断LAR的敏感性为80%,特异性为57.14%,阳性预测值为57.14,阴性预测值为80%。其中,LAR最常见的过敏原为混合螨虫。

最后,研究人员指出,鼻细胞学检查时的鼻嗜酸性粒细胞因其敏感性和程序简单,是诊断LAR的良好筛选工具,而特异性低导致了NPT在LAR确诊是还是需要的。

原始出处:

Phothijindakul N, Chusakul S, Aeumjaturapat S et al. Nasal Cytology as a Diagnostic Tool for Local Allergic Rhinitis. Am J Rhinol Allergy. 22 May 2019

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1805021, encodeId=39d6180502137, content=<a href='/topic/show?id=48c5e788217' target=_blank style='color:#2F92EE;'>#细胞学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77882, encryptionId=48c5e788217, topicName=细胞学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4723380, createdName=yangcx0915, createdTime=Thu Apr 09 05:13:00 CST 2020, time=2020-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047123, encodeId=6597204e1231e, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Fri May 01 08:13:00 CST 2020, time=2020-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027803, encodeId=6f1b202e80329, content=<a href='/topic/show?id=72784e6449c' target=_blank style='color:#2F92EE;'>#局部过敏性鼻炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47644, encryptionId=72784e6449c, topicName=局部过敏性鼻炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4b7363, createdName=pandamao2010, createdTime=Tue Sep 10 12:13:00 CST 2019, time=2019-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1723635, encodeId=a5211e2363518, content=<a href='/topic/show?id=7b08915917b' target=_blank style='color:#2F92EE;'>#诊断工具#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91591, encryptionId=7b08915917b, topicName=诊断工具)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c37033510464, createdName=surilei, createdTime=Wed Jan 08 12:13:00 CST 2020, time=2020-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329246, encodeId=ed52132924695, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sun Jun 09 05:13:00 CST 2019, time=2019-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405910, encodeId=7e04140591098, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Sun Jun 09 05:13:00 CST 2019, time=2019-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465853, encodeId=30da1465853a9, content=<a href='/topic/show?id=736b103508c6' target=_blank style='color:#2F92EE;'>#鼻腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103508, encryptionId=736b103508c6, topicName=鼻腔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=224e6763385, createdName=mnda, createdTime=Sun Jun 09 05:13:00 CST 2019, time=2019-06-09, status=1, ipAttribution=)]
    2019-06-09 膀胱癌
  6. [GetPortalCommentsPageByObjectIdResponse(id=1805021, encodeId=39d6180502137, content=<a href='/topic/show?id=48c5e788217' target=_blank style='color:#2F92EE;'>#细胞学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77882, encryptionId=48c5e788217, topicName=细胞学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4723380, createdName=yangcx0915, createdTime=Thu Apr 09 05:13:00 CST 2020, time=2020-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047123, encodeId=6597204e1231e, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Fri May 01 08:13:00 CST 2020, time=2020-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027803, encodeId=6f1b202e80329, content=<a href='/topic/show?id=72784e6449c' target=_blank style='color:#2F92EE;'>#局部过敏性鼻炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47644, encryptionId=72784e6449c, topicName=局部过敏性鼻炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4b7363, createdName=pandamao2010, createdTime=Tue Sep 10 12:13:00 CST 2019, time=2019-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1723635, encodeId=a5211e2363518, content=<a href='/topic/show?id=7b08915917b' target=_blank style='color:#2F92EE;'>#诊断工具#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91591, encryptionId=7b08915917b, topicName=诊断工具)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c37033510464, createdName=surilei, createdTime=Wed Jan 08 12:13:00 CST 2020, time=2020-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329246, encodeId=ed52132924695, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sun Jun 09 05:13:00 CST 2019, time=2019-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405910, encodeId=7e04140591098, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Sun Jun 09 05:13:00 CST 2019, time=2019-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465853, encodeId=30da1465853a9, content=<a href='/topic/show?id=736b103508c6' target=_blank style='color:#2F92EE;'>#鼻腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103508, encryptionId=736b103508c6, topicName=鼻腔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=224e6763385, createdName=mnda, createdTime=Sun Jun 09 05:13:00 CST 2019, time=2019-06-09, status=1, ipAttribution=)]
    2019-06-09 chg122
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    2019-06-09 mnda
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