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J Rheumatol:临床不活动的幼年特发性关节炎的急性发作与超声结果不相关

2018-04-12 xiangting MedSci原创

这项研究表明,将近一半CID患儿的8个常见受累关节中有1个存在超声异常。这些发现与随后2年随访中的临床急性发作无关。

随着更为先进的肌肉骨骼成像工具的出现,基于体检的幼年特发性关节炎(JIA)中临床不活动性疾病(CID)的定义受到挑战。这项研究旨在前瞻性地确定CID的JIA儿童中超声(US)异常的患病率及其临床意义。

纳入来自单个三级中心的有关节炎病史的≥4岁CID儿童,随访至少1年。在基线和随访时进行标准US膝关节、胫骨关节、距下关节和腕关节检查。US图像由2名小儿肌肉骨骼影像科医师进行评分。

40名CID患儿入组并临床随访。非活动性疾病的中位时间为1年。最常见的国际风湿病联盟JIA类别延伸为少关节JIA(30%)和类风湿因子阴性的多关节炎(38%)。基线时,在扫描的289个关节中,40名受试者中18名(45%)患儿的24个关节(8%)至少有1处异常发现。随访期间,在个别关节水平评估急性发作时,基线US结果的灵敏度为15%,阳性预测值为12%。第二次US的预测表现更差。

这项研究表明,将近一半CID患儿的8个常见受累关节中有1个存在超声异常。这些发现与随后2年随访中的临床急性发作无关。

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    2018-04-14 lmm397
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    2018-04-12 sunfeifeiyang

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