Baidu
map

Lancet Dia & Endo:1型糖尿病患者心脏衰竭的风险增加

2015-09-19 MedSci MedSci原创

糖尿病是心脏衰竭的危险因素,但由于几乎所有的心脏衰竭发生于老年个体,所以1型糖尿病的个体的心脏衰竭多余的风险和危险因素是未知的。该研究的目的是确定在1型糖尿病患者的总体和不同程度的蛋白尿患者血糖控制的患者心脏衰竭的风险。在这项前瞻性病例对照研究中,研究人员确定了所有1998年1月1日和2011年12月31日在瑞典全国糖尿病登记处注册的1型糖尿病患者,并从5个队列中随机抽取为每一位患者的对照,根据年

糖尿病是心脏衰竭的危险因素,但由于几乎所有的心脏衰竭发生于老年个体,所以1型糖尿病的个体的心脏衰竭剩余风险和危险因素是未知的。该研究的目的是确定在1型糖尿病患者的总体和不同程度的蛋白尿患者血糖控制的患者心脏衰竭的风险。

在这项前瞻性病例对照研究中,研究人员确定了所有1998年1月1日和2011年12月31日在瑞典全国糖尿病登记处注册的1型糖尿病患者,并从5个队列中随机抽取为每一位患者的对照,根据年龄,性别,和县进行了匹配,并通过Cox回归模型计算风险比就后续的住院心脏衰竭进行了比较。

在33402例患者的队列中(基线平均年龄在35岁以下[SD 14],15058[45%]名为女性,平均糖尿病持续时间为20.1年[SD 14.5]),在平均随访7.9年过程中,1062(3%)例患者被诊断为心脏衰竭而住院,在对照组随访的8.3年中,1325(1%)例患者因心脏衰竭而住院,调整了时间更新的年龄,性别,时间更新糖尿病病程,出生在瑞典,受教育程度和基线合并症后,HR为4.69(95%Cl 3.64-6.04)。在一个评分方式中更糟的血糖控制和蛋白尿的存在都增加了心脏衰竭的风险。在那些糖尿病控制良好的人群(校正后的HR 2.16[95%Cl 1.55-3.01])和那些没有白蛋白尿的人群(3.38[2.51-4.57 ])也增加了心脏衰竭的风险,但两个都控制良好且有正常白蛋白尿的亚组却没有增加该风险(1.59[0.70-3.58])。

与人群为基础的对照组相比,1型糖尿病个体因心脏衰竭被送往医院的风险增加了4倍。血糖控制差和肾功能受损大幅增加心脏衰竭的风险。

原始出处:

Annika Rosengren, Daniel Vestberg,Ann-Marie Svensson, et al.Long-term excess risk of heart failure in people with type 1 diabetes,Lancet Diabetes & Endocrinology,2015.9.17

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1968185, encodeId=a19d196818558, content=<a href='/topic/show?id=a4b96e542' target=_blank style='color:#2F92EE;'>#1型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=675, encryptionId=a4b96e542, topicName=1型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Fri Nov 27 18:15:00 CST 2015, time=2015-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828222, encodeId=7f83182822253, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu Aug 18 19:15:00 CST 2016, time=2016-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637156, encodeId=2dd7163e15671, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Mar 13 15:15:00 CST 2016, time=2016-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438694, encodeId=2473143869470, content=<a href='/topic/show?id=5c6b516e1dd' target=_blank style='color:#2F92EE;'>#心脏衰竭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51671, encryptionId=5c6b516e1dd, topicName=心脏衰竭)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Sep 21 01:15:00 CST 2015, time=2015-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473895, encodeId=584e14e3895f7, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Mon Sep 21 01:15:00 CST 2015, time=2015-09-21, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1968185, encodeId=a19d196818558, content=<a href='/topic/show?id=a4b96e542' target=_blank style='color:#2F92EE;'>#1型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=675, encryptionId=a4b96e542, topicName=1型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Fri Nov 27 18:15:00 CST 2015, time=2015-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828222, encodeId=7f83182822253, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu Aug 18 19:15:00 CST 2016, time=2016-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637156, encodeId=2dd7163e15671, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Mar 13 15:15:00 CST 2016, time=2016-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438694, encodeId=2473143869470, content=<a href='/topic/show?id=5c6b516e1dd' target=_blank style='color:#2F92EE;'>#心脏衰竭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51671, encryptionId=5c6b516e1dd, topicName=心脏衰竭)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Sep 21 01:15:00 CST 2015, time=2015-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473895, encodeId=584e14e3895f7, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Mon Sep 21 01:15:00 CST 2015, time=2015-09-21, status=1, ipAttribution=)]
    2016-08-18 howi
  3. [GetPortalCommentsPageByObjectIdResponse(id=1968185, encodeId=a19d196818558, content=<a href='/topic/show?id=a4b96e542' target=_blank style='color:#2F92EE;'>#1型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=675, encryptionId=a4b96e542, topicName=1型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Fri Nov 27 18:15:00 CST 2015, time=2015-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828222, encodeId=7f83182822253, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu Aug 18 19:15:00 CST 2016, time=2016-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637156, encodeId=2dd7163e15671, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Mar 13 15:15:00 CST 2016, time=2016-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438694, encodeId=2473143869470, content=<a href='/topic/show?id=5c6b516e1dd' target=_blank style='color:#2F92EE;'>#心脏衰竭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51671, encryptionId=5c6b516e1dd, topicName=心脏衰竭)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Sep 21 01:15:00 CST 2015, time=2015-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473895, encodeId=584e14e3895f7, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Mon Sep 21 01:15:00 CST 2015, time=2015-09-21, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1968185, encodeId=a19d196818558, content=<a href='/topic/show?id=a4b96e542' target=_blank style='color:#2F92EE;'>#1型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=675, encryptionId=a4b96e542, topicName=1型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Fri Nov 27 18:15:00 CST 2015, time=2015-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828222, encodeId=7f83182822253, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu Aug 18 19:15:00 CST 2016, time=2016-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637156, encodeId=2dd7163e15671, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Mar 13 15:15:00 CST 2016, time=2016-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438694, encodeId=2473143869470, content=<a href='/topic/show?id=5c6b516e1dd' target=_blank style='color:#2F92EE;'>#心脏衰竭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51671, encryptionId=5c6b516e1dd, topicName=心脏衰竭)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Sep 21 01:15:00 CST 2015, time=2015-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473895, encodeId=584e14e3895f7, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Mon Sep 21 01:15:00 CST 2015, time=2015-09-21, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1968185, encodeId=a19d196818558, content=<a href='/topic/show?id=a4b96e542' target=_blank style='color:#2F92EE;'>#1型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=675, encryptionId=a4b96e542, topicName=1型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Fri Nov 27 18:15:00 CST 2015, time=2015-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828222, encodeId=7f83182822253, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu Aug 18 19:15:00 CST 2016, time=2016-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637156, encodeId=2dd7163e15671, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Mar 13 15:15:00 CST 2016, time=2016-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438694, encodeId=2473143869470, content=<a href='/topic/show?id=5c6b516e1dd' target=_blank style='color:#2F92EE;'>#心脏衰竭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51671, encryptionId=5c6b516e1dd, topicName=心脏衰竭)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Sep 21 01:15:00 CST 2015, time=2015-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473895, encodeId=584e14e3895f7, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Mon Sep 21 01:15:00 CST 2015, time=2015-09-21, status=1, ipAttribution=)]

相关资讯

BMJ:胰岛素泵治疗可降低1型糖尿病患者心血管死亡率的50%

BMJy:胰岛素泵治疗可降低1型糖尿病患者心血管死亡率的50%据发表于BMJ的一项研究表明,使用胰岛素泵治疗的1型糖尿病患者较使用胰岛素注射治疗的1型糖尿病患者死于心血管疾病的风险较小(约50%)。基于瑞典国家糖尿病登记数据,2005年-2012年研究人员监测了18168名1型糖尿病患者。其中2441名患者使用胰岛素泵治疗,其他患者则应用胰岛素每日多次注射治疗。低风险研究人员发现,胰岛素泵使用者死

NEJM:1型糖尿病患者家庭环境使用人工β细胞的效果

在家庭环境中长时间使用人工β细胞(闭环胰岛素递送系统)的可行性,安全性,以及疗效尚未确立。在两个多中心,交叉,在自由生活的家庭条件下进行的随机对照研究中,研究人员比较了58例1型糖尿病患者闭环胰岛素给药与传感器增强泵治疗的效果。33名成人在白天和夜间以及25名儿童和青少年在使黑夜使用了闭环系统。使用闭环系统的参与者共12周,使用传感器增强泵治疗(对照)为相同的时间。主要终点是达到葡萄糖水平在70m

J Mol Med:新型血液检测手段提前诊断1型糖尿病

近日,发表于国际杂志Journal of Molecular Medicine上的一项研究报告中,来自伦敦帝国理工学院的研究人员通过研究,首次在患早期1型糖尿病患者的机体血液中发现了一种循环的特殊小分子,同时研究者还开发出了一种新型的简单血液检测手段,该技术可以在患者症状并未发生之前就可以对患者机体中的生物标志物进行检测。 研究者Mathieu Latreille说道,如果我们可以鉴别并且早日治

AJPEAM:棕色脂肪移植物或可有效逆转1型糖尿病发病

据估计在美国有125万人患1型糖尿病(T1D),1型糖尿病是一种自身免疫疾病,主要表现为胰腺会阻断胰岛素的产生,而胰岛素可以帮助机体加工来自食物中的葡萄糖。1型糖尿病可以忽然降临到儿童和成年人身上,同时患者一生都会对胰岛素注射及胰岛素泵产生依赖性;来自范德堡大学的研究人员此前通过对胰岛素缺失的糖尿病小鼠模型进行研究发现,胚胎棕色脂肪移植物可以在不利用胰岛素的情况下重新恢复小鼠机体的正常血糖水平。这

BMJ:胰岛素泵或降低1型糖尿病患者心血管风险

胰岛素泵——1型糖尿病患者的新选择虽然与2型糖尿病(T2DM)患者相比1型糖尿病(T1DM)患者的数量较小,但是1型糖尿病患者发生心血管疾病的风险却很大。与T2DM相比,对T1DM行强化血糖控制(使用胰岛素)可明显减少大血管和微血管的并发症,这种强化血糖控制通常采用每日多次注射(MDI)的方法。胰岛素泵,通常配备了血糖监测功能,可提供更简便且连续的胰岛素给药途径,年轻患者中使用的较多。尽管理论上胰

J Clin Endocr Metab:四种蛋白的水平较低导致了1型糖尿病的发生

据科学家报道,1型糖尿病患者血液中四种蛋白的水平显著降低,而这四种蛋白可保护机体的组织免于自身免疫系统的攻击。相反的是,1型糖尿病患者的一级亲属,与其存在相同的危险基因,但他们却并未患病,血液中这四种蛋白的水平也很高,Dr. Jin-Xiong She说道。据发表于《临床内分泌学与代谢杂志》的一项新的研究表明,不伴有这些危险基因的健康人血液中这四种蛋白——IL8, IL-1Ra,MCP-1及MIP

Baidu
map
Baidu
map
Baidu
map