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Nat Biotechnol:新技术可将胰腺外分泌细胞转化成为胰岛β细胞

2014-12-31 佚名 生物谷

近日,刊登在国际杂志Nature Biotechnology上的一篇研究论文中,来自哈佛干细胞研究所的研究人员通过研究表示,将成体细胞重编程为活体中的任何类型细胞后,细胞还可以长时间维持其功能。 文章中研究人员利用一种基因结合的方法来改变糖尿病成体小鼠的胰腺外分泌细胞,使得这些细胞转变成为胰岛素β分泌细胞从而治疗代谢疾病小鼠,并且改善小鼠的胰岛素产生。研究者Zhou博士表示,重编程的效率一直

近日,刊登在国际杂志Nature Biotechnology上的一篇研究论文中,来自哈佛干细胞研究所的研究人员通过研究表示,将成体细胞重编程为活体中的任何类型细胞后,细胞还可以长时间维持其功能。

文章中研究人员利用一种基因结合的方法来改变糖尿病成体小鼠的胰腺外分泌细胞,使得这些细胞转变成为胰岛素β分泌细胞从而治疗代谢疾病小鼠,并且改善小鼠的胰岛素产生。研究者Zhou博士表示,重编程的效率一直以来都是个问题,截止到目前为止,新产生的细胞数量会迅速减少,有时候也会完全消失;本文研究中我们发现重编程后的细胞也是有用的而且可以营造一种细胞得以生存的环境。

这项研究中,研究人员对小鼠研究了长达13个月,结果发现,诱导产生的胰岛素β分泌细胞可以保持一定的功能,而且活性较好;将胰腺外分泌细胞转化成为产生胰岛素的胰腺β分泌细胞这种技术或对于开发治疗糖尿病的新型疗法带来一定的思路,也对于理解1型和2型糖尿病的发病根源带来了希望。

1型糖尿病是一种影响大约300万美国人的自身免疫疾病,而2型糖尿病则是当下美国主要的流行性糖尿病,研究者表示,如果这种新型疗法策略可以成功应用于人类机体中,那么或许将有可能治疗一系列的糖尿病。最后研究者Zhou说道,我同很多临床医生进行了交流,询问他们是否我们的这种技术可以用于人类机体中,目前看法的较为分歧的,有些医生认为可以应用于人类机体当作疗法,而有些则认为该方法需要继续改进才能保证其安全性,后期我们还将通过更为深入的研究来优化当前的技术。

原始出处:

Li W, Cavelti-Weder C, Zhang Y, Clement K, Donovan S, Gonzalez G, Zhu J, Stemann M, Xu K, Hashimoto T, Yamada T, Nakanishi M, Zhang Y, Zeng S, Gifford D, Meissner A, Weir G, Zhou Q.Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells.Nat Biotechnol. 2014 Dec;32(12):1223-30.

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    2015-04-09 shock_melon
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    2015-11-09 gwc392
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    2015-08-14 liye789132251
  4. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618838, encodeId=9fa0161883873, content=<a href='/topic/show?id=007419239ca' target=_blank style='color:#2F92EE;'>#β细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19239, encryptionId=007419239ca, topicName=β细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b69919964433, createdName=ms24272190615788285182, createdTime=Fri Jan 02 00:28:00 CST 2015, time=2015-01-02, status=1, ipAttribution=)]
    2015-11-05 sunylz
  5. 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  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618838, encodeId=9fa0161883873, content=<a href='/topic/show?id=007419239ca' target=_blank style='color:#2F92EE;'>#β细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19239, encryptionId=007419239ca, topicName=β细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b69919964433, createdName=ms24272190615788285182, createdTime=Fri Jan 02 00:28:00 CST 2015, time=2015-01-02, status=1, ipAttribution=)]
    2015-04-11 x35042875

    他们的研究数据表明增加肠道中肠促胰素分泌细胞的数目,有可能成为改善血糖代谢的新型治疗方案。

    0

  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618838, encodeId=9fa0161883873, content=<a href='/topic/show?id=007419239ca' target=_blank style='color:#2F92EE;'>#β细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19239, encryptionId=007419239ca, topicName=β细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b69919964433, createdName=ms24272190615788285182, createdTime=Fri Jan 02 00:28:00 CST 2015, time=2015-01-02, status=1, ipAttribution=)]
    2015-06-02 cathymary
  8. 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  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618838, encodeId=9fa0161883873, content=<a href='/topic/show?id=007419239ca' target=_blank style='color:#2F92EE;'>#β细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19239, encryptionId=007419239ca, topicName=β细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b69919964433, createdName=ms24272190615788285182, createdTime=Fri Jan 02 00:28:00 CST 2015, time=2015-01-02, status=1, ipAttribution=)]
    2015-10-31 baoya
  10. 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