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Cancer Med:CHADS2分数可预测前列腺癌根治术后缺血性卒中的发生

2015-11-26 phylis 译 MedSci原创

前列腺癌患者卒中发生的风险增加,但是绝对卒中发生率与年龄和共发病相关。在行政索赔数据集,应用Charlson共发病指数分数(CCIS)评估风险。这篇研究评估CHADS2分数和CCIS分数对前列腺癌患者发生卒中的预测价值。这篇研究数据来源于台湾全民健康保险研究数据库(NHIRD)。1997年到2011年间,研究者选出非房颤(AF)患者5414名,这些患者患有前列腺癌病行前列腺癌根治术后。应用CHAD

前列腺癌患者卒中发生的风险增加,但是绝对卒中发生率与年龄和共发病相关。在行政索赔数据集,应用Charlson共发病指数分数(CCIS)评估风险。这篇研究评估CHADS2分数和CCIS分数对前列腺癌患者发生卒中的预测价值。

这篇研究数据来源于台湾全民健康保险研究数据库(NHIRD)。1997年到2011年间,研究者选出非房颤(AF)患者5414名,这些患者患有前列腺癌病行前列腺癌根治术后。应用CHADS2分数和CCIS分数将5年缺血性卒中发生的风险分层。自入院日,开始随访受试者直至缺血性卒中发生、死亡及5年随访期结束。

显著研究的缺血性卒中发生率为1.7%。与CCIS分数相比(CCIS = 0至1, 1.6%, CCIS = 2-3:1.7%,CCIS≥4:3.8%;AUC = 0.520),缺血性卒中的发生于CHADS2分数有更好的相关(CHADS2评分为0到1:0.02%,CHADS2评分= 2 至3:13.9%,CHADS2评分≥4:44.4%,;AUC = 0.978)。

研究结果显示,CHADS2分数较高的患者行前列腺癌根治术的前列腺癌患者,卒中发生的风险较高,CHADS2分数可用来预测缺血性卒中的发生。CHADS2分数较高,建议对前列腺癌患者进行心血管风险评估和处理。

原文出处:

Yang YW,  Lee SS, Chen CC4, et al.  CHADS2 scores as a predictor of ischemic stroke after radical prostatectomy.  Cancer Med. 2015, Nov 21.


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    2015-11-28 Handyuan

    赞一个

    0

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    2015-11-28 jeanqiuqiu
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