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JCEM：青春期前肌细胞内脂质沉积与代谢疾病风险相关（EPOCH研究）

2012-04-25 高晓方译 医学论坛网

内分泌代谢儿童肌细胞内脂肪沉积
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　　美国学者进行的EPOCH研究表明，在青春期前儿童中，肌细胞内脂质（IMCL）与内脏脂肪沉积有关，肌细胞内脂肪沉积与胰岛素抵抗标志物和心血管疾病风险相关。论文于2011年4月16日在线发表于《临床内分泌学与代谢杂志》（J Clin Endocrinol Metabol）。 　　在青少年和成人中肌细胞内脂质沉积与代谢失调相关，但目前对青春期前肌肉内脂肪沉积尚知之甚少

　　美国学者进行的EPOCH研究表明，在青春期前儿童中，肌细胞内脂质（IMCL）与内脏脂肪沉积有关，肌细胞内脂肪沉积与胰岛素抵抗标志物和心血管疾病风险相关。论文于2011年4月16日在线发表于《临床内分泌学与代谢杂志》（J Clin Endocrinol Metabol）。

　　在青少年和成人中肌细胞内脂质沉积与代谢失调相关，但目前对青春期前肌肉内脂肪沉积尚知之甚少。此项研究以青春期前和青春期早期儿童为受试者，并对IMCL蓄积与内脏脂肪以及胰岛素抵抗标志物和心血管疾病风险的相关性进行了评估。相关数据来自于一项回归性队列研究。构建多元线性回归模型用于数据分析。

　　研究共纳入441例儿童受试者，其中青春期前和青春期早期儿童分别为226和215例。在青春期前儿童中，IMCL和内脏脂肪之间存在显著相关性；对体质指数校正后亦如此。在所有儿童中，IMCL均与甘油三酯/高密度脂蛋白比相关（P=0.002），并且独立于整体肥胖。

　　原始链接：　　

Brumbaugh DE, Crume TL, Nadeau K, Scherzinger A, Dabelea D. Intramyocellular Lipid Is Associated with Visceral Adiposity, Markers of Insulin Resistance, and Cardiovascular Risk in Prepubertal Children: The EPOCH Study.J Clin Endocrinol Metab. 2012 Apr 16.
 


    

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    2012-06-29 smallant2015

    #JCEM#

    0

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    2012-08-29 rebeccajiejie

    #脂质沉积#

    0

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    2012-08-05 okhuali

    #EPOCH#

    0

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    2012-05-17 achengzhao

    #JCE#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1777377, encodeId=da941e773775a, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Fri Jun 29 22:16:00 CST 2012, time=2012-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810291, encodeId=aedc181029133, content=<a href='/topic/show?id=cf78844426e' target=_blank style='color:#2F92EE;'>#脂质沉积#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84442, encryptionId=cf78844426e, topicName=脂质沉积)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1cc90, createdName=rebeccajiejie, createdTime=Wed Aug 29 17:16:00 CST 2012, time=2012-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643077, encodeId=dacc16430e7ef, content=<a href='/topic/show?id=7d8b689351' target=_blank style='color:#2F92EE;'>#EPOCH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6893, encryptionId=7d8b689351, topicName=EPOCH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=113323104213, createdName=okhuali, createdTime=Sun Aug 05 23:16:00 CST 2012, time=2012-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062750, encodeId=1cae2062e50f9, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Thu May 17 05:16:00 CST 2012, time=2012-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275479, encodeId=f2cb12e54792d, content=<a href='/topic/show?id=5d0299032b9' target=_blank style='color:#2F92EE;'>#青春期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99032, encryptionId=5d0299032b9, topicName=青春期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Fri Apr 27 02:16:00 CST 2012, time=2012-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401982, encodeId=1db014019829e, content=<a href='/topic/show?id=193025463d8' target=_blank style='color:#2F92EE;'>#代谢疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25463, encryptionId=193025463d8, topicName=代谢疾病)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/F9591315BE4091482318EFFCD39C9D08/100, createdBy=bf9f2374681, createdName=windight, createdTime=Fri Apr 27 02:16:00 CST 2012, time=2012-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472910, encodeId=4c7214e2910b6, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Fri Apr 27 02:16:00 CST 2012, time=2012-04-27, status=1, ipAttribution=)]
    2012-04-27 zhzhxiang

    #青春期#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1777377, encodeId=da941e773775a, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Fri Jun 29 22:16:00 CST 2012, time=2012-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810291, encodeId=aedc181029133, content=<a href='/topic/show?id=cf78844426e' target=_blank style='color:#2F92EE;'>#脂质沉积#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84442, encryptionId=cf78844426e, topicName=脂质沉积)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1cc90, createdName=rebeccajiejie, createdTime=Wed Aug 29 17:16:00 CST 2012, time=2012-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643077, encodeId=dacc16430e7ef, content=<a href='/topic/show?id=7d8b689351' target=_blank style='color:#2F92EE;'>#EPOCH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6893, encryptionId=7d8b689351, topicName=EPOCH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=113323104213, createdName=okhuali, createdTime=Sun Aug 05 23:16:00 CST 2012, time=2012-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062750, encodeId=1cae2062e50f9, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Thu May 17 05:16:00 CST 2012, time=2012-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275479, encodeId=f2cb12e54792d, content=<a href='/topic/show?id=5d0299032b9' target=_blank style='color:#2F92EE;'>#青春期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99032, encryptionId=5d0299032b9, topicName=青春期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Fri Apr 27 02:16:00 CST 2012, time=2012-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401982, encodeId=1db014019829e, content=<a href='/topic/show?id=193025463d8' target=_blank style='color:#2F92EE;'>#代谢疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25463, encryptionId=193025463d8, topicName=代谢疾病)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/F9591315BE4091482318EFFCD39C9D08/100, createdBy=bf9f2374681, createdName=windight, createdTime=Fri Apr 27 02:16:00 CST 2012, time=2012-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472910, encodeId=4c7214e2910b6, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Fri Apr 27 02:16:00 CST 2012, time=2012-04-27, status=1, ipAttribution=)]
    2012-04-27 windight

    #代谢疾病#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1777377, encodeId=da941e773775a, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Fri Jun 29 22:16:00 CST 2012, time=2012-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810291, encodeId=aedc181029133, content=<a href='/topic/show?id=cf78844426e' target=_blank style='color:#2F92EE;'>#脂质沉积#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84442, encryptionId=cf78844426e, topicName=脂质沉积)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1cc90, createdName=rebeccajiejie, createdTime=Wed Aug 29 17:16:00 CST 2012, time=2012-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643077, encodeId=dacc16430e7ef, content=<a href='/topic/show?id=7d8b689351' target=_blank style='color:#2F92EE;'>#EPOCH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6893, encryptionId=7d8b689351, topicName=EPOCH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=113323104213, createdName=okhuali, createdTime=Sun Aug 05 23:16:00 CST 2012, time=2012-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062750, encodeId=1cae2062e50f9, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Thu May 17 05:16:00 CST 2012, time=2012-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275479, encodeId=f2cb12e54792d, content=<a href='/topic/show?id=5d0299032b9' target=_blank style='color:#2F92EE;'>#青春期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99032, encryptionId=5d0299032b9, topicName=青春期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Fri Apr 27 02:16:00 CST 2012, time=2012-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401982, encodeId=1db014019829e, content=<a href='/topic/show?id=193025463d8' target=_blank style='color:#2F92EE;'>#代谢疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25463, encryptionId=193025463d8, topicName=代谢疾病)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/F9591315BE4091482318EFFCD39C9D08/100, createdBy=bf9f2374681, createdName=windight, createdTime=Fri Apr 27 02:16:00 CST 2012, time=2012-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472910, encodeId=4c7214e2910b6, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Fri Apr 27 02:16:00 CST 2012, time=2012-04-27, status=1, ipAttribution=)]
    2012-04-27 花花1368

    #疾病风险#

    0

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