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Neurology:降低老年人认知衰退风险因素--从事艺术和工艺活动

2015-04-13 徐媛媛译 MedSci原创

这项研究旨在研究85岁及以上老人轻度认知障碍(MCI)的危险因素和保护因素。 该研究是一个以人群为基础的前瞻性研究,在基线时和每隔15个月对参与者进行综合评估,以确定MCI的发生率。在基线时,通过调查问卷对中年和晚年生活方式因素进行评估;血管疾病和合并症从参与者的医疗记录中收集得到。 该研究收纳了256位认知正常的参与者(平均年龄为87.3岁,女性占62%),在通过大约4.1年的随访期间有12

这项研究旨在研究85岁及以上老人轻度认知障碍(MCI)的危险因素和保护因素。

该研究是一个以人群为基础的前瞻性研究,在基线时和每隔15个月对参与者进行综合评估,以确定MCI的发生率。在基线时,通过调查问卷对中年和晚年生活方式因素进行评估;血管疾病和合并症从参与者的医疗记录中收集得到。

该研究收纳了256位认知正常的参与者(平均年龄为87.3岁,女性占62%),在通过大约4.1年的随访期间有121例罹患MCI。MCI的预测因素包括APOE ε4等位基因(危险比[HR] 1.89; p = 0.008),当前抑郁症状(HR 1.78; p = 0.02),中年患高血压(HR 2.43; p = 0.005),血管疾病(HR 1.13; p = 0.02)及慢性合并症(HR 1.08; p = 0.006)。本研究以年龄作为时间变量。研究显示,从事艺术(HR 0.27; p = 0.03)、工艺(HR 0.55; p = 0.02),社会活动(HR 0.45; p = 0.005)以及晚年使用计算机(HR 0.47;p = 0.008)的参与者在中年和晚年时期罹患MCI的风险下降。

结论:慢性疾病增加了MCI患病风险,而某些生活方式可减少85岁及以上老人的MCI的患病风险。MCI预防策略可能需要在中年时期就要开始并要在今后的生活中一直要坚持不能放弃。

原始出处

Roberts RO1, Cha RH2, Mielke MM2, Geda YE2, Boeve BF2, Machulda MM2, Knopman DS2, Petersen RC2.Risk and protective factors for cognitive impairment in persons aged 85 years and older.Neurology. 2015 Apr 8.

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    2016-02-16 yinhl1978
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    2015-09-04 kksonne
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    2015-04-13 zhouanxiu

    有意思

    0

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