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护士不得不知的脂肪乳剂使用注意事项

2018-02-12 佚名 河北省民政总医院

脂肪乳输注要点,供大家学习参考。

脂肪乳输注要点,供大家学习参考。

一、脂肪乳剂中能否加入电解质?

1.脂肪乳剂不宜加入电解质混合滴注

脂肪乳剂是油相、水相、乳化剂组成的乳剂,属热力学不稳定体系,可能发生分层、絮凝、转相、合并与破裂,加入电解质可能破坏乳化膜、增加乳剂的不稳定性。未经加药的脂肪乳剂中乳滴粒径大小均匀一致,都在0.2um左右,极少见到1~10um的乳滴。当加入氯化钠或氯化钾等一价离子24h后,部分乳滴粒径可增大至1~10um。而且不论有无其他溶液或电解质存在,只要在脂肪乳中加入硫酸镁或葡萄糖酸钙,1h内就可见到大量粒径>10um的乳滴出现。

故单瓶脂肪乳剂中不宜加入电解质溶液,因为加入的电解质会破坏乳滴表面的负电荷保护层影响脂肪颗粒的稳定性,导致颗粒融合,粒径增大,出现油水分离而不能使用。

2.脂肪乳剂与电解质为何在全肠外营养液中可以混合?

全肠外营养液的配制需在特定的环境中进行,配制时有严格的配制顺序。如先将微量元素、电解质加入氨基酸溶液中溶解或稀释,磷酸盐加入葡萄糖溶液中 (因钙剂和磷酸盐形成CaHPO4沉淀,故磷酸盐和钙剂稀释于不同的溶液中)溶解或稀释,脂溶性维生素和水溶性维生素混合后加入脂防乳剂中,然后将氨基酸溶液和葡萄糖溶液混合与软袋中,最后在软袋中加入脂防乳剂混合。

二、静脉滴注脂肪乳剂时的滴速是如何要求的?

静脉治疗护理技术操作规范及脂肪乳说明书中规定:

10%、20%脂肪乳注射液500ml的输注时间不少于5小时;

30%脂肪乳注射液250ml的输注时间不少于4小时。

新生儿和婴儿:10%、20%脂肪乳注射液每天使用剂量为0.5~4g(甘油三酯)/kg,输注速度不超过0.17g/(kg·小时)。每天最大用量不应超过4g/kg。只有在密切监测血清甘油三酯、肝功能、氧饱和度等指标的情况下输注剂量才可逐渐增加到每天4g/kg。

早产儿及低体重新生儿,最好是24小时连续输注,开始时每天剂量为0.5~1g/kg,以后逐渐增加到每天2g/kg。

三、输注脂肪乳剂需要选择什么样的输液器?

一次性普通聚氯乙烯(PVC)输液器不宜用于输注脂肪乳等脂溶性液体,原因是脂溶性药物会增加普通输液器中增塑剂DEHP的溶出。根据国家食品药品监督管理局2011年3月24日发布的《一次性使用输注器具产品注册技术审查指导原则》中规定:新生儿、青春期前的男性、怀孕期和哺乳期的妇女不宜使用PVC输液器,输注脂肪乳等脂溶性液体和药物时不宜使用PVC材质输液器,应使用非PVC材质输液器(超低密度及TPE)进行输注。

未经加药的脂肪乳剂中乳滴粒径大小均匀一致,都在0.2um左右,极少见到1~10um的乳滴。故脂肪乳注射液不能使用孔径为0.2um的精密输液器,因为脂肪乳微粒不能通过过滤器。

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    2018-02-13 半夏微凉

    学习了谢谢分享

    0

  3. 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channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Mon Feb 12 07:20:52 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287268, encodeId=dd4028e268b9, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Mon Feb 12 06:57:41 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287259, encodeId=b81e28e2598a, content=这个真的很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76802018286, createdName=元元maple, createdTime=Mon Feb 12 06:54:51 CST 2018, time=2018-02-12, status=1, ipAttribution=)]
    2018-02-12 雾夜芭蕾

    过滤器也是重要一环

    0

  4. 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createdName=半夏微凉, createdTime=Tue Feb 13 07:14:13 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287294, encodeId=80b428e294d3, content=过滤器也是重要一环, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Mon Feb 12 07:23:10 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287293, encodeId=616128e29356, content=还是要用特定器具, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Mon Feb 12 07:22:13 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287290, encodeId=f95028e290de, content=脂肪乳的注意事项, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Mon Feb 12 07:20:59 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287289, encodeId=e1a528e28906, content=护士不得不知的知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Mon Feb 12 07:20:52 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287268, encodeId=dd4028e268b9, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Mon Feb 12 06:57:41 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287259, encodeId=b81e28e2598a, content=这个真的很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76802018286, createdName=元元maple, createdTime=Mon Feb 12 06:54:51 CST 2018, time=2018-02-12, status=1, ipAttribution=)]
    2018-02-12 雾夜芭蕾

    还是要用特定器具

    0

  5. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Mon Feb 12 07:22:13 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287290, encodeId=f95028e290de, content=脂肪乳的注意事项, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Mon Feb 12 07:20:59 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287289, encodeId=e1a528e28906, content=护士不得不知的知识, beContent=null, objectType=article, 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encodeId=b81e28e2598a, content=这个真的很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76802018286, createdName=元元maple, createdTime=Mon Feb 12 06:54:51 CST 2018, time=2018-02-12, status=1, ipAttribution=)]
    2018-02-12 雾夜芭蕾

    密切注意甘油三酯

    0

  6. 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channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Mon Feb 12 07:20:52 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287268, encodeId=dd4028e268b9, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Mon Feb 12 06:57:41 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287259, encodeId=b81e28e2598a, content=这个真的很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76802018286, createdName=元元maple, createdTime=Mon Feb 12 06:54:51 CST 2018, time=2018-02-12, status=1, ipAttribution=)]
    2018-02-12 雾夜芭蕾

    原来时间也有限制

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Mon Feb 12 07:22:13 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287290, encodeId=f95028e290de, content=脂肪乳的注意事项, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Mon Feb 12 07:20:59 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287289, encodeId=e1a528e28906, content=护士不得不知的知识, beContent=null, objectType=article, 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encodeId=b81e28e2598a, content=这个真的很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76802018286, createdName=元元maple, createdTime=Mon Feb 12 06:54:51 CST 2018, time=2018-02-12, status=1, ipAttribution=)]
    2018-02-12 雾夜芭蕾

    脂肪乳的注意事项

    0

  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Mon Feb 12 07:22:13 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287290, encodeId=f95028e290de, content=脂肪乳的注意事项, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Mon Feb 12 07:20:59 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287289, encodeId=e1a528e28906, content=护士不得不知的知识, beContent=null, objectType=article, 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    2018-02-12 雾夜芭蕾

    护士不得不知的知识

    0

  9. 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channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Mon Feb 12 07:20:52 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287268, encodeId=dd4028e268b9, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Mon Feb 12 06:57:41 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287259, 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    2018-02-12 wzb521zf

    学习学习学习

    0

  10. 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channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Mon Feb 12 07:20:52 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287268, encodeId=dd4028e268b9, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Mon Feb 12 06:57:41 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287259, encodeId=b81e28e2598a, content=这个真的很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76802018286, createdName=元元maple, createdTime=Mon Feb 12 06:54:51 CST 2018, time=2018-02-12, status=1, ipAttribution=)]
    2018-02-12 元元maple

    这个真的很重要

    0

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