Contemp Clin Dent：甘油辅助益生菌罗伊氏乳杆菌对感染上皮细胞的抗炎作用

2018-06-10 MedSci MedSci原创

益生菌可通过诱导细胞因子来调节免疫系统并增强宿主免疫应答的能力。本研究旨在评估补充甘油的罗伊氏乳杆菌对暴露于细菌后上皮细胞表达的白细胞介素（IL）-8和人β-防御素（hBD）-2的转录水平的抗炎作用。将HaCat细胞系（105个细胞/mL）与变异链球菌ATCC-25175和牙龈卟啉单胞菌ATCC-33277（107个集落形成单位[CFU]/mL）混合培养24小时，并使用补充甘油的益生菌罗伊氏乳杆

益生菌可通过诱导细胞因子来调节免疫系统并增强宿主免疫应答的能力。本研究旨在评估补充甘油的罗伊氏乳杆菌对暴露于细菌后上皮细胞表达的白细胞介素（IL）-8和人β-防御素（hBD）-2的转录水平的抗炎作用。

将HaCat细胞系（105个细胞/mL）与变异链球菌ATCC-25175和牙龈卟啉单胞菌ATCC-33277（107个集落形成单位[CFU]/mL）混合培养24小时，并使用补充甘油的益生菌罗伊氏乳杆菌ATCC-55730（107CFU/mL）。随后，使用逆转录聚合酶链式反应（RT-PCR）分析HaCat细胞中IL-8和hBD-2的转录水平。另外，使用3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑鎓溴化物（MTT）测定法分析细胞活力。所有数据均采用单因素方差分析进行统计分析，P <0.05为显著性水平。

结果显示，MTT分析证实甘油补充的路氏乳杆菌对HaCat细胞没有细胞毒性作用（存活率> 90％）。暴露于两种细菌后，HaCat细胞中IL-8和hBD-2的mRNA表达增加。甘油补充罗伊氏乳杆菌的存在显著降低了HaCat细胞中IL-8和hBD-2的表达（P <0.05）。

综上所述，该研究结果表明，补充甘油的罗伊氏乳杆菌降低了IL-8和hBD-2的表达，该研究结果部分解释了益生菌抗炎的机制。但是，需要进一步的研究来验证这种益生菌效果。

原始出处：

Widyarman AS, Drestia AM, et al., The Anti-inflammatory Effects of Glycerol-supplemented Probiotic Lactobacillus reuteri on Infected Epithelial cells In vitro. Contemp Clin Dent. 2018 Apr-Jun;9(2):298-303. doi: 10.4103/ccd.ccd_53_18.

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2018-08-12 xiongke010

#乳杆菌#

80 0
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2018-06-12 wangtianj2009@

#罗伊氏乳杆菌#

0 0
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2018-06-12 lizhou0208

#上皮细胞#

61 0
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2018-06-12 一天没事干

很好的学习机会

104 0
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2018-06-10 为你把脉

VB哈哈哈还好还好哈

105 0
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2018-06-10 天地飞扬

了解一下.谢谢分享!

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