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消化系统肿瘤,与这7个饮食习惯息息相关

2017-04-06 Elaine 医学界肿瘤频道

消化道肿瘤是对饮食最敏感的肿瘤之一。

流行病学研究表明,消化道肿瘤是对改善饮食最敏感的肿瘤之一。

饮食致癌的机制分成几类:直接DNA损害(如亚硝酸盐类),细胞色素激活或抑制(如酒精),致癌物激活(如腌制的食物),直接细胞毒性(如霉菌毒素),氧化损害(如饱和脂肪)生理学改变(如稻子,膳食纤维)和激素的影响(如植物性雌激素类)。

以下是研究已经证实的导致消化系统肿瘤的危险因素。

危险因素一:亚硝胺类化合物

多种亚硝胺能诱发动物的食管癌、胃癌等疾病。

当摄入食物(如:酸菜、烧烤食物)中亚硝胺在胃内酸性条件下特别是在维生素C摄入不足时,胺类和亚硝酸盐易合成亚硝胺。

同时,亚硝酸盐在PH值为1~4时和胃内胺类物质极易形成亚硝酰胺,不需要任何代谢激活就能在胃中直接诱发肿瘤。

烧烤鱼肉时亦可产生多环芳香烃,增加胃癌的发生。

危险因素二:真菌毒素

粮食、酸菜及霉变食物中某些真菌及其代谢物是食管癌、胃癌的重要危险因素。

这些真菌(如:黄曲霉毒素)不仅能将硝酸盐还原成亚硝酸盐,还能分解蛋白质,增加食物中胺的含量,促进亚硝胺的合成。

危险因素三:高盐、高脂肪、高胆固醇膳食

大量进食饱和脂肪、高盐(咸鱼、腌肉等)可腐蚀胃粘膜,破坏胃粘膜屏障,增加胃癌的发病率。

胆固醇、脂肪的致癌作用可能通过胆汁酸介导,高脂饮食能刺激胆汁酸及胆固醇的分泌和排泄,促进大肠癌的发病。

危险因素四:饮食刺激

食物粗糙、进食过烫、暴饮暴食、三餐不定时等习惯,造成食管黏膜的慢性理化刺激、机械性胃粘膜损伤、胃液分泌紊乱等增加消化系统肿瘤的发病率。

危险因素五:营养不良和微量元素缺乏

流行病学调查表明,食物、饮水和土壤内元素钼、铜、硼、锌、镁、铁含量较低都可能与食管癌的发生间接有关。

是某些氧化酶和硝酸盐还原酶的重要组成部分,钼缺乏可引起食物中硝酸盐的聚集。

天津医学院任大林等调查了97对病例对照血清维生素A与胃癌发病率的关系,发现胃癌组维生素A含量明显低于对照组,且维生素A水平与胃癌患病危险率有明显的剂量依赖性关系。

调查国内胃癌高发地区600名35-64岁有胃粘膜肠化生的患者,血中维生素C、β-C、维生素E的水平显着降低。

危险因素六:饮酒

流行病学发现许多食管癌患者有大量饮酒史。

酒精可作为致癌物的溶剂,促进致癌物进入食管,造成食物黏膜损伤,为食管癌的发生创造条件。

危险因素七:吸烟

烟草中化学物质不仅与食管癌有关,而且能增加胃癌的发病率。

动物实验证明,烟草的烟雾中含有多种对胰腺器官特异性的致癌物质。其次,烟草中的尼古丁可以促进体内儿茶酚胺释放,导致血液中胆固醇水平明显升高。在某种方式下,高脂血症可诱发胰腺癌

四种方法,预防消化系统肿瘤

预防方法一:调味品和茶

研究表明,大蒜能抑制N-乙基亚硝胺的合成。食用大蒜后可使胃酸分泌功能增加。

大蒜对细菌尤其是HP有杀灭作用,大蒜中含硫复合物能保护哺乳动物上皮细胞DNA,大蒜中的硫代硫酸盐能抑制HP的生长。而且富含黄酮醇(尤其是四羟基黄酮)有助于致癌物的去除。

食用绿茶可能预防多种肠道肿瘤。绿茶的主要成分EGCG(没食子儿茶素没食子酸酯),有多种作用机制,如细胞内抗氧化作用,抑制致癌物质形成和血管生成及癌细胞增殖。

预防方法二:维生素和微量元素

维生素A:

维生素A以抗氧化和增加细胞间隙连接交通为主,并可增强上皮细胞防御功能,保护黏膜协助复原。给予动物高维生素A饮食能显着抑制DMH、黄曲霉菌素B的诱癌作用。

还有研究表示,胡萝卜素有更强的防癌效果。

富含维生素A的食物有:猪肝、鸭肝、鸭蛋黄、鸡肝、西蓝花、胡萝卜(红)等。

叶酸:

叶酸的组成成分有:谷氨酸、对氨基苯甲酸和喋呤啶;主要是参与SAM供甲基过程以维持甲基化状态,参与基因调控,抑制癌基因表达。

墨西哥的一项病例对照研究显示,叶酸能降低胃肠型癌的发生。

叶酸广泛存在于动物、植物性食物中,如:猪肝、牛肉、芦笋、油菜、橘、草莓等。

维生素C:

维生素C为抗氧化剂,可清除自由基,并可通过视黄醇和维生素A酸刺激免疫系统及活化间隙连接交通,维持细胞分化的正常状态,抑制亚硝胺的形成,增强肝解毒。

通过实验证明,维生素C确实可以阻止胃中一种致癌物N-亚消基的形成,从而降低胃癌风险。

维生素C含量高的食物有:酸枣、鲜枣、猕猴桃、苜蓿、萝卜缨(白)、芥蓝等。


研究表明,维生素D是防止结肠上皮细胞恶变,调节其生长、分化的重要因素。

维生素D主要通过肉类、蛋黄及接触日光获得,大多数食物不含有维生素D。

维生素E:

维生素E除了抗氧化抑制自由基的形成外,还能在基因突变前后阻止细胞的恶性转化或过度增生。

植物油是维生素E的主要来源,蛋类、肉类、水果及蔬菜中含量较少。

硒:

硒可以改变致癌剂的代谢与解毒作用,可通过抑制谷胱甘肽过氧化酶抑制剂如DMH的氧化过程和脂质过氧化,从而保持细胞膜结构和功能的健全,防止对DNA损害。

增加血硒水平能改善其免疫状态及机体抗氧化功能,有助于发挥机体自身抗癌功能。

预防方法三:脂类

椰子油中的月硅酸可以抑制幽门螺旋杆菌的生长,因此椰子油能强化肠黏膜的生态系统。

预防方法四:膳食纤维

高膳食纤维可显着抑制偶氮甲氧烷(AOX)对大肠的致癌作用。

谷类植物纤维在酸性环境下对亚硝胺有强烈的清除作用,明显降低胃内亚硝酸盐的浓度。

此外,植物中的植物雌激素、酚复合物、抗淀粉、低聚果糖等都有抗肿瘤成分。

癌症的发病过程常常需要数年,而且由多种因素共同作用所致。而良好的生活习惯、均衡的膳食是远离癌症的最佳办法。

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    2017-04-16 1581eb98e5m

    科普一下,有利于沟通

    0

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likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Fri Apr 07 07:55:10 CST 2017, time=2017-04-07, status=1, ipAttribution=)]
    2017-04-11 Jianghuiqin

    不错!值得向大家普及知识!

    0

  5. 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    2017-04-09 春暖花开8785

    科普做的很到位,简明易懂。

    0

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  7. 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likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Fri Apr 07 07:55:10 CST 2017, time=2017-04-07, status=1, ipAttribution=)]
    2017-04-07 Albert Wu

    预防方法一:调味品和茶

    0

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    2017-04-07 186****0580(小山羊)

    学习了谢谢了。

    0

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likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Fri Apr 07 07:55:10 CST 2017, time=2017-04-07, status=1, ipAttribution=)]
    2017-04-07 cqykthl

    收藏了,用于患者教育

    0

  10. 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    2017-04-07 医艺依意

    值得注意,科普要做好

    0

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