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J Rheumatol：青少年皮肌炎血清可溶性细胞质Bcl-2蛋白水平升高

2018-08-11 xiangting MedSci原创

青少年皮肌炎Bcl-2蛋白Fas抗原凋亡相关蛋白谱
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JDM患者表现出独特的凋亡相关蛋白谱，而这导致了疾病的发展。

这项研究旨在评价青少年皮肌炎（JDM）中可溶性Fas抗原（sFas）、sFas配体（sFasL）、可溶性肿瘤坏死因子相关凋亡诱导配体、可溶性细胞质Bcl-2蛋白（sBcl-2）血清水平，T、B淋巴细胞和单核细胞中的Fas和Bcl-2表达，及其与红细胞沉降率、C-反应蛋白（CRP）、儿童肌炎评估量表和人工肌肉测试的关联。

对于JDM或幼年特发性关节炎（JIA）患者和健康对照，使用ELISA确定血清水平，流式细胞仪检测外周细胞表达。

JDM患者的sBcl-2升高，而这与CRP相关。与JIA和/或健康对照比较，CD3+、CD4+和CD8+T淋巴细胞中Bcl-2表达升高，而Fas表达降低。

JDM患者表现出独特的凋亡相关蛋白谱，而这导致了疾病的发展。

原始出处：

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1691571, encodeId=143316915e13c, content=<a href='/topic/show?id=1581989e101' target=_blank style='color:#2F92EE;'>#青少年皮肌炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98971, encryptionId=1581989e101, topicName=青少年皮肌炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a64a29244032, createdName=tamgche, createdTime=Sat Nov 10 21:45:00 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342769, encodeId=c8b4342e690e, content=好好学习天天学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Tue Sep 04 21:42:06 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1707317, encodeId=25931e07317a7, content=<a href='/topic/show?id=9948325e6d' target=_blank style='color:#2F92EE;'>#BCL-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3257, encryptionId=9948325e6d, topicName=BCL-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e84031401266, createdName=ms3323097325231039, createdTime=Wed Mar 13 20:45:00 CST 2019, time=2019-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309270, encodeId=459513092e0cb, content=<a href='/topic/show?id=e947e198270' target=_blank style='color:#2F92EE;'>#皮肌炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71982, encryptionId=e947e198270, topicName=皮肌炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Mon Aug 13 07:45:00 CST 2018, time=2018-08-13, status=1, ipAttribution=)]
    2018-11-10 tamgche

    #青少年皮肌炎#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1691571, encodeId=143316915e13c, content=<a href='/topic/show?id=1581989e101' target=_blank style='color:#2F92EE;'>#青少年皮肌炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98971, encryptionId=1581989e101, topicName=青少年皮肌炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a64a29244032, createdName=tamgche, createdTime=Sat Nov 10 21:45:00 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342769, encodeId=c8b4342e690e, content=好好学习天天学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Tue Sep 04 21:42:06 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1707317, encodeId=25931e07317a7, content=<a href='/topic/show?id=9948325e6d' target=_blank style='color:#2F92EE;'>#BCL-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3257, encryptionId=9948325e6d, topicName=BCL-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e84031401266, createdName=ms3323097325231039, createdTime=Wed Mar 13 20:45:00 CST 2019, time=2019-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309270, encodeId=459513092e0cb, content=<a href='/topic/show?id=e947e198270' target=_blank style='color:#2F92EE;'>#皮肌炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71982, encryptionId=e947e198270, topicName=皮肌炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Mon Aug 13 07:45:00 CST 2018, time=2018-08-13, status=1, ipAttribution=)]
    2018-09-04 zwjnj2

    好好学习天天学习

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1691571, encodeId=143316915e13c, content=<a href='/topic/show?id=1581989e101' target=_blank style='color:#2F92EE;'>#青少年皮肌炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98971, encryptionId=1581989e101, topicName=青少年皮肌炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a64a29244032, createdName=tamgche, createdTime=Sat Nov 10 21:45:00 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342769, encodeId=c8b4342e690e, content=好好学习天天学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Tue Sep 04 21:42:06 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1707317, encodeId=25931e07317a7, content=<a href='/topic/show?id=9948325e6d' target=_blank style='color:#2F92EE;'>#BCL-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3257, encryptionId=9948325e6d, topicName=BCL-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e84031401266, createdName=ms3323097325231039, createdTime=Wed Mar 13 20:45:00 CST 2019, time=2019-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309270, encodeId=459513092e0cb, content=<a href='/topic/show?id=e947e198270' target=_blank style='color:#2F92EE;'>#皮肌炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71982, encryptionId=e947e198270, topicName=皮肌炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Mon Aug 13 07:45:00 CST 2018, time=2018-08-13, status=1, ipAttribution=)]
    2019-03-13 ms3323097325231039

    #BCL-2#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1691571, encodeId=143316915e13c, content=<a href='/topic/show?id=1581989e101' target=_blank style='color:#2F92EE;'>#青少年皮肌炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98971, encryptionId=1581989e101, topicName=青少年皮肌炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a64a29244032, createdName=tamgche, createdTime=Sat Nov 10 21:45:00 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342769, encodeId=c8b4342e690e, content=好好学习天天学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Tue Sep 04 21:42:06 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1707317, encodeId=25931e07317a7, content=<a href='/topic/show?id=9948325e6d' target=_blank style='color:#2F92EE;'>#BCL-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3257, encryptionId=9948325e6d, topicName=BCL-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e84031401266, createdName=ms3323097325231039, createdTime=Wed Mar 13 20:45:00 CST 2019, time=2019-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309270, encodeId=459513092e0cb, content=<a href='/topic/show?id=e947e198270' target=_blank style='color:#2F92EE;'>#皮肌炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71982, encryptionId=e947e198270, topicName=皮肌炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Mon Aug 13 07:45:00 CST 2018, time=2018-08-13, status=1, ipAttribution=)]
    2018-08-13 yuanming7

    #皮肌炎#

    0

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