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JAMA Oncology:全身炎症反应和肌肉减少症与非转移性结直肠癌预后的关系

2017-12-16 MedSci MedSci原创

全身炎症反应和肌肉减少很容易评估,在许多肿瘤中可以预测死亡率情况,并且有改善的可能。炎症和肌肉减少症联合可能有助于识别预后不良的早期结直肠癌患者。JAMA Oncology近期发表了一篇文章,研究全身炎症反应和肌肉减少症与非转移性结直肠癌患者预后的关系。

全身炎症反应和肌肉减少很容易评估,在许多肿瘤中可以预测死亡率情况,并且有改善的可能。炎症和肌肉减少症联合可能有助于识别预后不良的早期结直肠癌患者。JAMA Oncology近期发表了一篇文章,研究全身炎症反应和肌肉减少症与非转移性结直肠癌患者预后的关系。

作者分析了2006年到2011年间确诊的2470例结直肠癌患者。评估炎症反应使用的指标是中性粒细胞与淋巴细胞比值(NLR)。作者取诊断前24个月NLR的平均值。参照组为NLR小于3,表明炎症反应轻或无炎症反应。使用CT评估骨骼肌指数。对体重正常或超重的男性及女性,肌肉减少症标准为小于52cm2/m2和38cm2/m2,对肥胖男性和女性标准分别为小于54cm2/m2和47cm2/m2。2470例患者中,1219例为女性,平均年龄63岁。平均随访时间6年,共656例患者死亡,其中357例死于结直肠癌。NLR增高与肌肉减少有关。NLR≥3和肌肉减少症均可独立预测总生存和结直肠癌相关死亡。同时有肌肉减少症和NLR≥3的患者死亡风险加倍。

文章最后认为,诊断前炎症反应与诊断时肌肉减少症有关。肌肉减少症联合炎症使死亡风险加倍,表明这些常规收集的分子标志可以增加预测效力。对患者炎症/免疫反应影响骨骼肌改变的理解也许会为治疗方案提供新的思路,改善肿瘤预后。

原始出处:
Elizabeth M.Cespedes Feliciano,Candyce H.Kroenke,et al.Association of Systemic Inflammation and Sarcopenia With Survival in Nonmetastatic Colorectal Cancer.JAMA Oncology.December 2017 doi:10.1001/jamaoncol.2017.2319

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    2018-09-17 minlingfeng
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    2017-12-19 大爰

    学习了谢谢分享!!

    0

  8. 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