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JAMA:非心脏手术后新发房颤患者需警惕中风风险

2020-09-02 MedSci原创 MedSci原创

对于接受非心脏手术后出现房颤的患者,其卒中或短暂性脑缺血发作的风险显著增加

对于接受非心脏手术患者,术后房颤(AF)与不良预后的研究尚不充分,近日研究人员比较了非心脏手术后新发术后AF与未出现AF患者的结局差异。
 
 
本次研究为在明尼苏达州奥姆斯特德县进行的回顾性队列研究。2000年至2013年间,452名患者接受非心脏手术后30天内出现AF,以手术后30天内出现房颤患者为对照。研究的主要结果为缺血性脑卒中或短暂性脑缺血发作(TIA)。 次要结果包括房颤、全因死亡率和血管死亡率。
 
术后AF患者的中位年龄为75岁,51.8%为男性。 术后AF患者的CHA2DS2-VASc评分高于无AF组(中位数,4 vs 3)。在5.4年的随访中,术后AF组发生71例缺血性中风或TIA,266例AF复发,571例死亡,其中172例与心血管有关。术后AF患者与非AF患者相比,缺血性卒中或TIA发作的风险显著增高(发病率为18.9 vs 10.0/1000人-年;5年绝对风险差[RD]为4.7%;HR为2.69)。术后AF患者后续AF复发(发病率为136.4 vs 21.6/1000人-年,5年绝对危险度为39.3%,HR为7.94)和全因死亡(死亡133.2 vs 86.8/1000人-年,5年绝对危险度为9.4%,相对危险度为1.66)风险增加,但术后AF和无AF患者的心血管死亡风险无显著性差异(发病率为42.5 vs 25.0/1000人-年,5年绝对危险度为6.2%,HR为1.51)。
 
 
对于接受非心脏手术后出现房颤的患者,其卒中或短暂性脑缺血发作的风险显著增加。
 
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  5. 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  6. 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  7. 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createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Wed Sep 02 20:57:00 CST 2020, time=2020-09-02, status=1, ipAttribution=)]
    2020-09-03 ms7000000139248197

    0

  8. 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encryptionId=ce0258131ff, topicName=新发房颤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=788d7780866, createdName=若水125, createdTime=Fri Sep 04 08:57:00 CST 2020, time=2020-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488298, encodeId=14e3148829856, content=<a href='/topic/show?id=f37799413a6' target=_blank style='color:#2F92EE;'>#非心脏手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99413, encryptionId=f37799413a6, topicName=非心脏手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5438409695, createdName=bnurmamat, createdTime=Fri Sep 04 08:57:00 CST 2020, time=2020-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614561, encodeId=2eb51614561bb, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Fri Sep 04 08:57:00 CST 2020, time=2020-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882520, encodeId=dbb8882520a2, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200903/79d0f015e6084e5ca462828ca002414e/27d5d6b264cb4eeebf7092dc1fb8eae8.jpg, createdBy=22155415237, createdName=ms7000000139248197, createdTime=Thu Sep 03 18:14:31 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882435, encodeId=fa1a882435b5, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5aa05412020, createdName=韩杰, createdTime=Thu Sep 03 12:05:05 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882377, encodeId=21808823e71d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Thu Sep 03 08:26:21 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031301, encodeId=aede10313011d, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Wed Sep 02 20:57:00 CST 2020, time=2020-09-02, status=1, ipAttribution=)]
    2020-09-03 韩杰

    好好学习一下

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1739716, encodeId=19371e39716af, content=<a href='/topic/show?id=ff0c2262459' target=_blank style='color:#2F92EE;'>#中风风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22624, encryptionId=ff0c2262459, topicName=中风风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9ba34554146, createdName=1249898am26暂无昵称, createdTime=Thu Feb 18 21:57:00 CST 2021, time=2021-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819382, encodeId=e0481819382fb, content=<a href='/topic/show?id=210c9941411' target=_blank style='color:#2F92EE;'>#非心脏手术后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99414, encryptionId=210c9941411, topicName=非心脏手术后)], attachment=null, authenticateStatus=null, createdAvatar=, 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channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Fri Sep 04 08:57:00 CST 2020, time=2020-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882520, encodeId=dbb8882520a2, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200903/79d0f015e6084e5ca462828ca002414e/27d5d6b264cb4eeebf7092dc1fb8eae8.jpg, createdBy=22155415237, createdName=ms7000000139248197, createdTime=Thu Sep 03 18:14:31 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882435, encodeId=fa1a882435b5, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5aa05412020, createdName=韩杰, createdTime=Thu Sep 03 12:05:05 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882377, encodeId=21808823e71d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Thu Sep 03 08:26:21 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031301, encodeId=aede10313011d, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Wed Sep 02 20:57:00 CST 2020, time=2020-09-02, status=1, ipAttribution=)]
    2020-09-03 14818eb4m67暂无昵称

    学习

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1739716, encodeId=19371e39716af, content=<a href='/topic/show?id=ff0c2262459' target=_blank style='color:#2F92EE;'>#中风风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22624, encryptionId=ff0c2262459, topicName=中风风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9ba34554146, createdName=1249898am26暂无昵称, createdTime=Thu Feb 18 21:57:00 CST 2021, time=2021-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819382, encodeId=e0481819382fb, content=<a href='/topic/show?id=210c9941411' target=_blank style='color:#2F92EE;'>#非心脏手术后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99414, encryptionId=210c9941411, topicName=非心脏手术后)], attachment=null, authenticateStatus=null, createdAvatar=, 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channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Fri Sep 04 08:57:00 CST 2020, time=2020-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882520, encodeId=dbb8882520a2, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200903/79d0f015e6084e5ca462828ca002414e/27d5d6b264cb4eeebf7092dc1fb8eae8.jpg, createdBy=22155415237, createdName=ms7000000139248197, createdTime=Thu Sep 03 18:14:31 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882435, encodeId=fa1a882435b5, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5aa05412020, createdName=韩杰, createdTime=Thu Sep 03 12:05:05 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882377, encodeId=21808823e71d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Thu Sep 03 08:26:21 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031301, encodeId=aede10313011d, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Wed Sep 02 20:57:00 CST 2020, time=2020-09-02, status=1, ipAttribution=)]
    2020-09-02 心介

    房颤,临床上碰到很多哦

    0

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