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Lancet Public Health:全球2005年-2014年期间出生的女孩未来发生宫颈癌的风险预估

2021-04-19 Nebula MedSci原创

预计2094年时,全球约有1.16亿宫颈癌病例!

据统计,2018年,全球共有57万新发宫颈癌病例,31.1万人死于宫颈癌。世卫组织(WHO)发起了一项旨在消除宫颈癌作为公共卫生问题的倡议。消除宫颈癌是一个长期目标,需要长期的承诺。

国际癌症研究机构(IARC/WHO)的Iacopo Baussano博士及其同事为了支持地方当局实施人乳头瘤病毒(HPV)疫苗接种计划,对国家/地区特定的宫颈癌负担以及HPV疫苗接种对当今如果不接种疫苗可能会患宫颈癌的年轻女孩的预期影响进行了评估。

研究人员将2018年全球疫苗计划的年龄特异性发病率和联合国人口预测的按年龄划分的队列特异性死亡率结合起来,量化了2005年-2014年期间出生的女孩在没有接种HPV疫苗的情况下的预期宫颈癌病例数量。根据疫苗接种导致的HPV患病率降低以及每种HPV类型对宫颈癌发病率的相对贡献来估算可预防的癌症。此外,还评估了二价疫苗(HPV 16和18型)和七价疫苗(HPV 16、18、31、33、45、52和58型)可以预防的宫颈癌病例数。

全球2005年-2014年期间出生的女孩的宫颈癌发生风险

在全球范围内,不接种疫苗的情况下,预计2094年时本次研究队列人群的宫颈癌负担会达到1.16亿例病例。这些负担的75%将主要集中在非洲和亚洲的25个国家,这些地区的宫颈癌病例预计将成倍增长,非洲将达到5600万例病例,亚洲将达到4500万例病例

以针对HPV 16和18型的HPV疫苗进行全球免疫,并针对HPV 31、33和45型进行交叉保护,可以预防约8700万例病例

总之,接种HPV疫苗可显著降低未来的宫颈癌负担,特别是对于非发达地区国家,应大力鼓励推动年轻女性接种HPV疫苗。公共卫生决策者应妥善制定相关政策。

原始出处:

Maxime Bonjour, et al. Global estimates of expected and preventable cervical cancers among girls born between 2005 and 2014: a birth cohort analysis. The Lancet Public Health. April 14, 2021.

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    2022-03-06 zhouqu_8
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    2021-11-22 howi
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    2021-04-22 科研科研科研

    鼓励接种HPV疫苗

    0

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    2021-04-21 一闲
  5. [GetPortalCommentsPageByObjectIdResponse(id=1861436, encodeId=1c93186143657, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Mar 06 13:02:45 CST 2022, time=2022-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1831127, encodeId=ab43183112e78, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Mon Nov 22 14:02:45 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959286, encodeId=4cf29592861e, content=鼓励接种HPV疫苗, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210110/e6124a4b19bc40ce8afaae096d21126b/dd778ac260c9416eb87e7d08139507f5.jpg, createdBy=4d2f5079605, createdName=科研科研科研, createdTime=Thu Apr 22 08:33:41 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408288, encodeId=f7d21408288be, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Wed Apr 21 09:02:45 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621898, encodeId=f5cf1621898a4, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Wed Apr 21 09:02:45 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034276, encodeId=58a010342e67f, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Mon Apr 19 21:02:45 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958451, encodeId=2a459584513e, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Mon Apr 19 18:41:31 CST 2021, time=2021-04-19, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1861436, encodeId=1c93186143657, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Mar 06 13:02:45 CST 2022, time=2022-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1831127, encodeId=ab43183112e78, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Mon Nov 22 14:02:45 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959286, encodeId=4cf29592861e, content=鼓励接种HPV疫苗, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210110/e6124a4b19bc40ce8afaae096d21126b/dd778ac260c9416eb87e7d08139507f5.jpg, createdBy=4d2f5079605, createdName=科研科研科研, createdTime=Thu Apr 22 08:33:41 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408288, encodeId=f7d21408288be, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Wed Apr 21 09:02:45 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621898, encodeId=f5cf1621898a4, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Wed Apr 21 09:02:45 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034276, encodeId=58a010342e67f, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Mon Apr 19 21:02:45 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958451, encodeId=2a459584513e, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Mon Apr 19 18:41:31 CST 2021, time=2021-04-19, status=1, ipAttribution=)]
    2021-04-19 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

    0

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    2021-04-19 jyzxjiangqin

    好文章!

    0

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