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J Gastroen Hepatol:全年龄段人群肠癌风险评估模型

2017-07-03 zhangfan MedSci原创

研究开发了一种基于临床以及实验室参数的晚期肠癌风险评价体系,该体系可用于全年龄段人群,特别是50岁以下人群的肠癌风险评估

对于50岁以下人群是否应进行结肠镜检查以筛查肠癌风险?近日研究人员开发了一种预测晚期大肠癌(ACN)的风险评分模型,旨在对全年龄段的无症状患者进行临床-实验室指标评估。

在这项横断面研究中,2003至2012年间,共70812名韩国成年参与者进行了结肠镜检查。研究人员利用利用多元逻辑回归模型建立风险评分模型并进行内部验证。

研究发现,总的晚期大肠癌发病率为1.4% (956/70 812)。研究人员建立了一套15点评分模型,包括年龄、性别、结直肠癌家族史、吸烟、体重指数、空腹血糖水平、低密度脂蛋白胆固醇和癌胚抗原。根据受试者得分情况,验证队列参与者可以分为5个风险等级(低的,边缘的,中等的,高的,非常高的)与之对应的晚期肠癌发病率分别为0.7%, 1.3%, 2.7%, 6.6%以及13.2%。相对于边缘风险人群,低风险组患者的晚期肠癌风险下降了50.3%,相反,中等、高以及非常高的风险组人群的晚期肠癌风险分别增长了2、5、10倍。本研究开发的晚期肠癌评分体系与亚洲-太平洋结直肠筛查评分相比,显示出更好的辨别力(P = 0.003)。

研究开发了一种基于临床以及实验室参数的晚期肠癌风险评价体系,该体系可用于全年龄段人群,特别是50岁以下的中青年人群肠癌风险评估。

原始出处:


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    2018-02-19 sjq027
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    2017-08-05 许安
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    2017-07-05 gwc384
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    2017-07-03 蔬菜

    非常感谢分享,学习了

    0

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    2017-07-03 明月清辉

    谢谢分享,学习了

    0

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