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Thyroid:注意了!!女性孕早期甲状腺功能会影响子女的学习

2015-11-02 Mechront 译 MedSci原创

有研究表明,孕妇甲状腺功能减退和/或低甲状腺素血症会导致儿童神经发育不良,不过也有研究得出不一致的结果。研究者进行了一项研究,在孕早期(mean±SD 10.7+-2.8周孕)获取孕妇血液样本 (n=5791),以及后代16岁时血液样本(n=5829)。在后代8岁时通过老师评价参与者在学校的表现等,在其16岁时自我评价表现。根据参与者健康记录等识别可能的严重的智力缺损或轻度认知受限。研究结果显示,

有研究表明,孕妇甲状腺功能减退和/或低甲状腺素血症会导致儿童神经发育不良,不过也有研究得出不一致的结果。

研究者进行了一项研究,在孕早期(平均±SD10.7+-2.8周孕)获取孕妇血液样本 (n=5791),以及后代16岁时血液样本(n=5829)。在后代8岁时通过老师评价参与者在学校的表现等,在其16岁时自我评价表现。根据参与者健康记录等识别可能的严重的智力缺损或轻度认知受限。

研究结果显示,亚临床甲减孕妇生育的女孩比甲功正常孕妇生育的女孩,自我评价对数学感到更头大更困难(OR 1.62, 95% CI 1.06-2.49)。亚临床甲减孕妇生育的男孩比甲功正常孕妇生育的男孩更容易留级复读(OR 5.46,95% CI 1.19-25.06)。甲亢孕妇的后代在青少年时期觉得数学越来越难 (OR 1.61, 95% CI 1.01-2.49)。孕妇甲状腺功能障碍并不会导致后代严重的智力缺损或轻度认知受限。后代16岁时,甲亢女孩比甲功正常的女孩,觉得芬兰语学习更困难(OR 2.82,95% CI 1.42-5.61)。而甲亢男孩与正常组相比,觉得芬兰语和/或数学更难 (OR 2.13,95% CI 1.26-3.62)。

研究结构表明,女性孕早期甲状腺功能异常将会导致后代青少年时期学校表现更差。另外青少年本身的甲状腺功能障碍也会导致学习上的一些困难。

原始出处:


Päkkilä FM, Männistö T,et al.Maternal and child's thyroid function and child's intellect and scholastic performance.Thyroid. 2015 Oct 6.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=52297, encodeId=a02d5229e21, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Jan 05 22:51:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52298, encodeId=aa3a52298fa, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=200, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Jan 05 22:51:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42781, encodeId=242642e81f4, content=又木有积分,不看了。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sat Nov 07 23:14:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42779, encodeId=8ca042e7974, content=甲功已经列入孕检项目了吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sat Nov 07 23:13:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394173, encodeId=907713941e35b, content=<a href='/topic/show?id=1646452e771' target=_blank style='color:#2F92EE;'>#孕早期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45277, encryptionId=1646452e771, topicName=孕早期)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Wed Nov 04 14:13:00 CST 2015, time=2015-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42485, encodeId=83ed4248512, content=孕检甲功很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=77e41648823, createdName=miaotao, createdTime=Wed Nov 04 12:29:00 CST 2015, time=2015-11-04, status=1, ipAttribution=)]
    2016-01-05 xyfg98

    有意思

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=52297, encodeId=a02d5229e21, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Jan 05 22:51:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52298, encodeId=aa3a52298fa, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=200, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Jan 05 22:51:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42781, encodeId=242642e81f4, content=又木有积分,不看了。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sat Nov 07 23:14:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42779, encodeId=8ca042e7974, content=甲功已经列入孕检项目了吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sat Nov 07 23:13:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394173, encodeId=907713941e35b, content=<a href='/topic/show?id=1646452e771' target=_blank style='color:#2F92EE;'>#孕早期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45277, encryptionId=1646452e771, topicName=孕早期)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Wed Nov 04 14:13:00 CST 2015, time=2015-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42485, encodeId=83ed4248512, content=孕检甲功很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=77e41648823, createdName=miaotao, createdTime=Wed Nov 04 12:29:00 CST 2015, time=2015-11-04, status=1, ipAttribution=)]
    2016-01-05 xyfg98

    0

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    2015-11-07 三三五五

    又木有积分,不看了。。。

    0

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    2015-11-07 三三五五

    甲功已经列入孕检项目了吗?

    0

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    2015-11-04 miaotao

    孕检甲功很重要

    0

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研究者进行了一项回顾性队列研究,纳入了出生于2004-2010年日本神户的76 920名儿童,研究对象均在出生时、4个月、9个月、18个月以及3岁时进行体检,研究者收集研究对象4个月时家庭吸烟环境情况和18个月、3岁时乳牙龋齿发生情况。研究者根据家长问卷调查评估孕期吸烟情况和婴儿4个月时二手烟暴露情况。该研究的主要结局指标为乳牙龋齿发生率。研究数据显示,纳入研究对象中,有55.3%(n=42 52

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MAVIDOS早期结果表明:孕期补充VD可以阻止女性骨量下降(12月-2月),并且增加宝宝的骨量。相反,另一项大型研究却指出孕期补充VD并不会改善母儿的骨健康,并且高剂量的VD供应还会削弱孕妇的股骨。MAVIDOS:超过1000名女性在孕12周随机分为VD3组(1000-IU (25-µg)/d)和安慰剂组。该研究指出“季节”对研究结果影响非常大。日光足的季节出生的宝宝,出生后2周通过DEXA评估

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为达到消除疟疾的目标,除了预防疟疾再感染,还应阻止其再燃,然而目前关于疟疾再燃的不良影响尚不明确。研究者对2003-2012年间分娩的1819名莫桑比克女性进行了研究,估计恶性疟原虫的流行情况。研究者通过镜检、组织活检、qPCR以及流式细胞仪监测对寄生虫的IgG抗体反应情况。研究数据显示,qPCR对恶性疟原虫的检测率从2003年的33%下降到2010年的2%,不过在2012年该值又增加到6%,抗疟

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已经有很多研究表明,孕妇糖尿病会增加后代先天性心脏病 (CHD) 风险。尽管临场上诊断了2型糖尿病或妊娠期糖尿病是CHD的危险因素,但是亚临床的血糖异常和胰岛素代谢异常更常见,那么它们会不会也和CHD相关呢?研究者进行了一项病例-对照研究,探究2种不同CHD表型与孕妇孕中期血糖值和胰岛素情况的联系。该研究共纳入了277名孕妇,其中55名分娩法洛四联症患儿 (TOF),42名分娩大动脉右旋患儿 (d

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