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MCB：RNA聚合酶III调控巨噬细胞功能促进肿瘤存活

2015-03-23 佚名 生物谷

RNA聚合酶III巨噬细胞肿瘤
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近日，来自英国的科学家在生物学期刊Molecular and Cellular Biology在线发表了他们关于RNA聚合酶III调控巨噬细胞功能的最新研究进展。   研究人员指出，肿瘤微环境中的炎症具有许多促癌症发展效应。特别是肿瘤相关巨噬细胞（TAM）能够产生许多细胞因子，促进恶性肿瘤细胞存活，血管生成以及转移维持肿瘤生长。肿瘤相关巨噬细胞内细胞因子的合成与蛋白质合成过程紧密相关

近日，来自英国的科学家在生物学期刊Molecular and Cellular Biology在线发表了他们关于RNA聚合酶III调控巨噬细胞功能的最新研究进展。
 
研究人员指出，肿瘤微环境中的炎症具有许多促癌症发展效应。特别是肿瘤相关巨噬细胞（TAM）能够产生许多细胞因子，促进恶性肿瘤细胞存活，血管生成以及转移维持肿瘤生长。肿瘤相关巨噬细胞内细胞因子的合成与蛋白质合成过程紧密相关，而蛋白质的翻译过程又依赖于RNA聚合酶III转录形成的众多tRNA。因此研究RNA聚合酶III对肿瘤相关巨噬细胞的功能发挥有何影响具有重要意义。
 
研究人员发现用来源于细菌细胞壁的脂多糖（LPS）刺激小鼠巨噬细胞能够上调表达tRNA的相关基因的转录。NF-kB是介导炎症信号的一个关键转录因子,LPS处理能够会增强NF-kB的p65亚基与tRNA基因的作用。除此之外，研究人员还发现p65能够直接与RNA聚合酶III复合物中的转录因子TFIIIB相互作用，并且p65过表达会诱导pol III依赖性的转录过程。抑制巨噬细胞内的pol III活性能够阻止巨噬细胞分泌细胞因子并抑制其吞噬作用，这也是巨噬细胞的两个关键功能特征。
 
这项研究揭示了RNA聚合酶III对巨噬细胞功能的重要调控作用，证明RNA聚合酶III可能对于恶性肿瘤细胞相关的免疫反应具有重要影响。
 
原始出处：

Damian Graczyk, Robert J White and Kevin M. Ryan1.RNA Polymerase III is required for macrophage function[J].MCB,2015,35(7).doi: 10.1128/MCB.00990-14.

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    2015-06-30 wjywjy

    #RNA聚合酶#

    0

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    2015-11-15 wwzzly

    #RNA聚合酶III#

    0

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    2016-01-15 juliusluan78

    #III#

    0

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    2015-04-08 晓辰

    #聚合酶#

    0

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    2015-03-25 般若傻瓜

    #细胞功能#

    0

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