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Lancet：大数据看中风的预防（INTERSTROKE试验）

2016-07-17 佚名 来宝网

中风缺血性中风脑出血
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最近麦克马斯特大学的研究者称，全世界90%的中风，发病原因大致可以归结为10个，但是十个致病因素会因为地域的不同而所占的比例也有差别。近期发表在《柳叶刀》（The Lancet ）杂志上的文章表明，中风的预防是目前中风最紧迫的事情，但是地域差异性会影响预防策略的实施。中风是引起死亡和残疾的主要原因，尤其是对于中低收入人群来说，中风的两种形式包括由于血栓引起的缺血性中风，大概占到85%；另外一种是脑

最近麦克马斯特大学的研究者称，全世界90%的中风，发病原因大致可以归结为10个，但是十个致病因素会因为地域的不同而所占的比例也有差别。


近期发表在《柳叶刀》（The Lancet ）杂志上的文章表明，中风的预防是目前中风最紧迫的事情，但是地域差异性会影响预防策略的实施。

中风是引起死亡和残疾的主要原因，尤其是对于中低收入人群来说，中风的两种形式包括由于血栓引起的缺血性中风，大概占到85%；另外一种是脑出血引起的中风，占到总人数的15%。
由该研究机构Martin O'Donnell博士和Salim Yusuf博士主导的该研究与来自32个国家的科学家一道对22个国家的6000名受试者进行了研究，其中对主要对这10种中风的危险因素进行了评估，该项目被称为INTERSTROKE，受试者来自欧洲、亚洲。美洲、非洲以及大洋洲，通过对各种类型的人群进行调查，找到中风的主要原因。

PHRI 项目负责人O'Donnell 说：“该研究通过对世界主要地区和国家，分地区和范围的研究中风危险因素，我们已经发现约有90%的中风患者致病原因无非是这十个，同时研究也指出高血压是在这十种原因中最重要的一个，也是能够有效缓解中风最重要的靶标。”

调查者在观察不同危险因素的同时发现，如果危险因素消失，患病比例将会大大降低。

高血压消除后会减少48%，如果会多运动患病比例会降到36%，再加上合理的饮食会降到19%。
而且在这十种致病因素中也不是孤立存在的，比如说肥胖和糖尿病之间的密切联系，当同时有这两种致病因素时，中风的概率就更大了。

原始出处：


Mente A, O'Donnell M, Rangarajan S, Dagenais G, Lear S, McQueen M, Diaz R, Avezum A, Lopez-Jaramillo P, Lanas F, Li W, Lu Y, Yi S, Rensheng L, Iqbal R, Mony P, Yusuf R, Yusoff K, Szuba A, Oguz A, Rosengren A, Bahonar A, Yusufali A, Schutte AE, Chifamba J, Mann JF, Anand SS, Teo K, Yusuf S; PURE, EPIDREAM and ONTARGET/TRANSCEND Investigators.Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies.Lancet. 2016 May 20. pii: S0140-6736(16)30467-6. doi: 10.1016/S0140-6736(16)30467-6. [Epub ahead of print]

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    2016-08-07 仁者大医

    #ERS#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1878177, encodeId=de0d18e817726, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sun Aug 07 17:38:00 CST 2016, time=2016-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828542, encodeId=0259182854260, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Wed Jan 25 14:38:00 CST 2017, time=2017-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145498, encodeId=44a614549888, content=好文值得点赞！继续关注学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:25:48 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93338, encodeId=86139333822, content=wonderful, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd381668530, createdName=1de069d8m82(暂无匿称), createdTime=Mon Jul 18 12:05:00 CST 2016, time=2016-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93317, encodeId=54f29331e14, content=有意义的大数据研究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160623/IMG576B1DCFE14EC6883.jpg, createdBy=b21a1740334, createdName=Dr.Ji, createdTime=Mon Jul 18 07:25:00 CST 2016, time=2016-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93302, encodeId=4d6093302dc, content=非常好的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Jul 17 22:44:00 CST 2016, time=2016-07-17, status=1, ipAttribution=)]
    2017-01-25 howi

    #Lancet#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1878177, encodeId=de0d18e817726, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sun Aug 07 17:38:00 CST 2016, time=2016-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828542, encodeId=0259182854260, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Wed Jan 25 14:38:00 CST 2017, time=2017-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145498, encodeId=44a614549888, content=好文值得点赞！继续关注学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:25:48 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93338, encodeId=86139333822, content=wonderful, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd381668530, createdName=1de069d8m82(暂无匿称), createdTime=Mon Jul 18 12:05:00 CST 2016, time=2016-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93317, encodeId=54f29331e14, content=有意义的大数据研究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160623/IMG576B1DCFE14EC6883.jpg, createdBy=b21a1740334, createdName=Dr.Ji, createdTime=Mon Jul 18 07:25:00 CST 2016, time=2016-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93302, encodeId=4d6093302dc, content=非常好的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Jul 17 22:44:00 CST 2016, time=2016-07-17, status=1, ipAttribution=)]
    2016-10-11 ylzr123

    好文值得点赞！继续关注学习。

    0

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    2016-07-18 1de069d8m82(暂无匿称)

    wonderful

    0

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    2016-07-18 Dr.Ji

    有意义的大数据研究。

    0

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    2016-07-17 oo902

    非常好的文章

    0

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