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Ann Pharm Fr:增强型抗生素滴眼液治疗细菌性角膜炎:18个月的临床病例和抗生素易感性的审查!

2017-12-31 cuiguizhong MedSci原创

法国昂热大学医院药剂科的Saillard J近日在Ann Pharm Fr发表了一项重要的工作,他们在感染性角膜炎患者中,对随访18个月内所鉴定的微生物及其抗生素敏感性进行了研究。

法国昂热大学医院药剂科的Saillard J近日在Ann Pharm Fr发表了一项重要的工作,他们在感染性角膜炎患者中,对随访18个月内所鉴定的微生物及其抗生素敏感性进行了研究。

他们采用回顾性、描述性和非比较性的研究方法,对2015年1月至2016年6月期间,在昂热大学附属医院接受强化抗生素眼药水治疗的患者进行文献研究,提取其中的医学和生物学数据。研究的主要内容包括所涉及的细菌及其对抗生素的敏感性。同时比较治疗开始时和结束时患者的视力。

他们总共研究了四十八例病人。在31名患者中鉴定出同一种细菌和分属24种不同物种的43种病原体。最常见的微生物是革兰氏阳性球菌(55.8%),包括金黄色葡萄球菌(14.0%)和表皮葡萄球菌(14.0%)。所有革兰氏阴性杆菌占鉴定出细菌的30.2%,包括9.3%的铜绿假单胞菌。革兰氏阳性球菌均对万古霉素无耐药性,所有革兰氏阴性杆菌均对头孢他啶和丁胺卡那霉素敏感。用他们自己配置的抗生素滴眼液(阿米卡星50mg / mL,头孢他啶50mg / mL,万古霉素25mg / mL)三者中的至少一种进行治疗,患者的视力都得到明显改善(P = 0.043)。

因此,他们认为,这项研究有助于确定感染性角膜炎患者的细菌生态。在鉴定出的细菌中,没有发现一个细菌能够对医院药房配置的三种强化抗生素眼药水中的任何一种产生抗性。这些滴眼液甚至可以在鉴定出细菌之前,使患者得到快速有效的治疗,改善视力。

原文出处:

Saillard, J., et al., Bacterial keratitis treated by strengthened antibiotic eye drops: An 18 months review of clinical cases and antibiotic susceptibilities. Ann Pharm Fr, 2017.

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    2018-06-12 xsm928
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    2018-06-09 jj000001
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    2018-01-02 snowpeakxu
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    2017-12-31 有备才能无患

    法国昂热大学医院药剂科的SaillardJ近日在AnnPharmFr发表了一项重要的工作.他们在感染性角膜炎患者中.对随访18个月内所鉴定的微生物及其抗生素敏感性进行了研究.

    0

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    2017-12-31 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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