真实世界的数据支持赛诺菲的Toujeo用于I型糖尿病

2018-03-20 MedSci MedSci原创

赛诺菲公布了来自英国真实世界的研究数据，显示其长效基础胰岛素类似物Toujeo在治疗I型糖尿病患者中的功效。这些数据首次在芝加哥内分泌协会第100届年会暨博览会ENDO 2018上发布，表明该药物与患有该病症的患者的HbA1c的显着改善，具有统计学意义，平均差异从基线至六个月的-4.4毫摩尔/摩尔。该研究还显示，在Toujeo（Gla-300）开始治疗后报告糖尿病酮症酸中毒（DKA）或严重低血糖的

赛诺菲公布了来自英国真实世界的研究数据，显示其长效基础胰岛素类似物Toujeo在治疗I型糖尿病患者中的功效。

这些数据首次在芝加哥内分泌协会第100届年会暨博览会ENDO 2018上发布，表明该药物与患有该病症的患者的HbA1c的显着改善，具有统计学意义，平均差异从基线至六个月的-4.4毫摩尔/摩尔。

该研究还显示，在Toujeo（Gla-300）开始治疗后报告糖尿病酮症酸中毒（DKA）或严重低血糖的患者人数没有变化。

赛诺菲指出，在Gla-300发病后六个月内，患者报告的低血糖和DKA发作总数分别为31/299（10％）和7/299（2％）。

"Gla-300作为II型糖尿病的基础治疗已经很成熟，并且其广泛的临床数据支持其使用。然而，这一证据对于I型糖尿病的治疗并不是很充分。"Dudley Group NHS基金会信托和首席研究作者Terence Pang指出。

"这些研究结果提供了强有力的真实世界证据，可以提供对日常使用药物有效性的评估，并增加临床数据以进一步帮助[卫生保健专业人员]做出临床决策。"

Toujeo于2015年4月在欧洲获得批准，此后III期数据显示虽然血糖控制与赛诺菲先前的胰岛素Lantus的血糖控制作用相当，但安全性良好，II型患者白天和晚上证实低血糖的发生率更低。

低血糖症是人们服用胰岛素最常见的副作用之一。

原文出处：http：//www.pharmatimes.com/news/real_world_data_back_sanofis_toujeo_for_type_i_diabetes_1228401

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2018-03-30 Drhzm308

呵呵.知道了

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2018-03-22 王秀

学习了.涨知识了!

105 0
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2018-03-22 王秀

学习了.涨知识了!

111 0
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2018-03-22 chenshujs

#真实世界#

67 0
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2018-03-21 张新亮1853311252142e2fm

值得学习.很好

109 0
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2018-03-21 秀红

学习了

105 0
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2018-03-21 121832a9m88暂无昵称

学习了

64 0
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2018-03-20 131****2916

不错的文章值得推荐

49 0
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2018-03-20 清风拂面

谢谢分享学习

56 0

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