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Brit J Cancer:肾结石与肾细胞癌和上尿路上皮癌的风险

2018-12-21 xing.T MedSci原创

由此可见,肾结石与乳头状RCC风险增加有关,但与透明细胞RCC风险无关,没有发现UTUC亚型的异质性。

近日,肿瘤领域权威杂志British Journal of Cancer上发表了一篇研究文章,研究人员旨在评估荷兰饮食和癌症队列研究中肾结石与肾细胞癌(RCC)和上尿路上皮癌(UTUC)风险之间的关系。

该研究总共有120852名55-69岁的参与者,这些参与者在基线时完成了关于饮食、医疗条件和其他癌症危险因素的自填问卷(1986年)。经过20.3年的癌症随访,4352名亚组成员中有544名RCC病例和140名UTUC病例符合病例队列分析的条件。研究人员通过多变量校正的比例风险模型估算了风险比(HR)和95%置信区间(CI)。

与无肾结石相比,肾结石与RCC风险增加有关(HR:1.39,95%CI为1.05-1.84)。肾结石与乳头状RCC风险增加相关(HR:3.08,95%CI为1.55-6.11),但不是透明细胞RCC(HR:1.14,95%CI为0.79-1.65)。患有肾结石的参与者的UTUC风险增加(HR:1.66,95%CI为1.03-2.68)。在输尿管和肾盂中UTUC未发现相关性的异质性。与晚期诊断相比,早期肾结石诊断(≤40岁)与RCC和UTUC风险增加有关。

由此可见,肾结石与乳头状RCC风险增加有关,但与透明细胞RCC风险无关,没有发现UTUC亚型的异质性。

原始出处:

Jeroen A. A. van de Pol,et al.Kidney stones and the risk of renal cell carcinoma and upper tract urothelial carcinoma: the Netherlands Cohort Study. British Journal of Cancer. 2018. https://www.nature.com/articles/s41416-018-0292-6

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    2018-12-30 jyzxjiangqin

    肾结石与肾细胞癌。

    0

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    2018-12-22 一个字-牛

    学习了谢谢分享

    0

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    2018-12-21 jyzxjiangqin

    肾结石与肾细胞癌。

    0

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