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BJOG:多囊卵巢综合征(PCOS)患者双胎妊娠时早产儿风险增加

2015-03-21 MedSci译 MedSci原创

多囊卵巢综合征(PCOS)是以稀发排卵或无排卵、高雄激素或胰岛素抵抗、多囊卵巢为特征的内分泌紊乱的症候群。不孕为其病症之一。而双胎妊娠是高危妊娠的危险因素。因此,诊断为PCOS女性怀孕得之不易,双胎妊娠更是可遇不可求,而怀胎十月,一朝顺利分娩,更是难得可贵。 近期<span style="font-size:11.0pt;font-family:&qu

多囊卵巢综合征(PCOS)是以稀发排卵或无排卵、高雄激素或胰岛素抵抗、多囊卵巢为特征的内分泌紊乱的症候群。不孕为其病症之一。而双胎妊娠是高危妊娠的危险因素。因此,诊断为PCOS女性怀孕得之不易,双胎妊娠更是可遇不可求,而怀胎十月,一朝顺利分娩,更是难得可贵。

近期Lovvik TS等人对双胎妊娠的PCOS孕产妇进行了一项基于瑞典人群的队列研究,以探究其妊娠结局和围生期结局。

该研究纳入了1995-2009年间瑞典20965名双胎妊娠女性,其中226名被诊断为PCOS。研究者们采集了早产儿、低体重儿、剖宫产、子痫前期、5分钟Apgar评分小于7、围生期死亡率等相关数据。

研究结果显示,PCOS组其早产儿发生率更高(51% versus 43%, RR 1.18 [95% CI 1.03-1.37]),尤其是自然早产(37%versus 28%; RR 1.30 [95% CI 1.09-1.55])和32周孕之前的早产(14% versus 8%, RR 1.62 [95% CI 1.10-2.37])。PCOS组低体重儿发生率也更高(48% versus 39%, RR 1.40 [95% CI 1.09-1.80]),但是校正孕龄后,PCOS组和正常组比较差异消失。剖宫产发生率、子痫前期发生率、5分钟Apgar评分小于7发生率和围生期死亡率在两组间无差异。

研究结果表明,诊断为多囊卵巢综合征(PCOS)女性,一旦双胎妊娠,其早产儿发生风险增高,因此在妊娠期间应做好其产前检查和随访,评估其风险。

原始出处:
Løvvik TS, Wikström AK, Neovius M, Stephansson O, Roos N, Vanky E.Pregnancy and perinatal outcomes in women with polycystic ovary syndrome and twin births: a population-based cohort study. BJOG. 2015 Mar 11. doi: 10.1111/1471-0528.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1718360, encodeId=e1741e18360b0, content=<a href='/topic/show?id=5ce04315043' target=_blank style='color:#2F92EE;'>#多囊卵巢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43150, encryptionId=5ce04315043, topicName=多囊卵巢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c91632558486, createdName=kalseyzl, createdTime=Tue Oct 06 01:06:00 CST 2015, time=2015-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19221, encodeId=ea7e1922110, content=球扩张,在世界许多地方ART仍然无法施行,提醒很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=196, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Tue Mar 31 23:29:00 CST 2015, time=2015-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1780359, encodeId=a36b1e803593e, content=<a href='/topic/show?id=a5cd3502b5' target=_blank style='color:#2F92EE;'>#BJOG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3502, encryptionId=a5cd3502b5, topicName=BJOG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Sun Dec 20 12:06:00 CST 2015, time=2015-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430513, encodeId=2d88143051333, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 23 07:06:00 CST 2015, time=2015-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18624, encodeId=668e18624b1, content=与多囊有关系吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=191, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Sun Mar 22 09:28:00 CST 2015, time=2015-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18609, encodeId=460018609e5, content=提醒很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Mar 21 20:03:00 CST 2015, time=2015-03-21, status=1, ipAttribution=)]
    2015-03-31 x35042875

    球扩张,在世界许多地方ART仍然无法施行,提醒很重要

    0

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    2015-12-20 hittouch
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    2015-03-22 xiaoai5777

    与多囊有关系吗?

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1718360, encodeId=e1741e18360b0, content=<a href='/topic/show?id=5ce04315043' target=_blank style='color:#2F92EE;'>#多囊卵巢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43150, encryptionId=5ce04315043, topicName=多囊卵巢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c91632558486, createdName=kalseyzl, createdTime=Tue Oct 06 01:06:00 CST 2015, time=2015-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19221, encodeId=ea7e1922110, content=球扩张,在世界许多地方ART仍然无法施行,提醒很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=196, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Tue Mar 31 23:29:00 CST 2015, time=2015-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1780359, encodeId=a36b1e803593e, content=<a href='/topic/show?id=a5cd3502b5' target=_blank style='color:#2F92EE;'>#BJOG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3502, encryptionId=a5cd3502b5, topicName=BJOG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Sun Dec 20 12:06:00 CST 2015, time=2015-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430513, encodeId=2d88143051333, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 23 07:06:00 CST 2015, time=2015-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18624, encodeId=668e18624b1, content=与多囊有关系吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=191, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Sun Mar 22 09:28:00 CST 2015, time=2015-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18609, encodeId=460018609e5, content=提醒很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Mar 21 20:03:00 CST 2015, time=2015-03-21, status=1, ipAttribution=)]
    2015-03-21 lovetcm

    提醒很重要

    0

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