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Ann Surg：淋巴结转移灶的定位是食管腺癌患者生存的独立预测因子

2016-08-06 Mechront 译 MedSci原创

淋巴结转移食管腺癌分期
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目的：上纵隔及腹腔动脉新辅助治疗和切除后发现淋巴结转移不改变食管癌的TNM分类。这些遥远的淋巴结转移对生存的影响仍不清楚。因此研究者进行了研究，探究食管或胃食管交界(GEJ) 腺癌患者新辅助治疗后食管切除术治疗患者，淋巴结转移位置的预后意义。方法：纳入2003-3至2013-9的479例食道远端或GEJ腺癌患者，进行了新辅助化疗后经胸食管切除术，根据切除标本淋巴结阳性定位，分析生存期。结果：253

目的：上纵隔及腹腔动脉新辅助治疗和切除后发现淋巴结转移不改变食管癌的TNM分类。这些遥远的淋巴结转移对生存的影响仍不清楚。因此研究者进行了研究，探究食管或胃食管交界(GEJ) 腺癌患者新辅助治疗后食管切除术治疗患者，淋巴结转移位置的预后意义。

方法：纳入2003-3至2013-9的479例食道远端或GEJ腺癌患者，进行了新辅助化疗后经胸食管切除术，根据切除标本淋巴结阳性定位，分析生存期。

结果：253例患者有淋巴结转移的切除标本。这些患者中，92例患者局部区域节点淋巴结转移，中位无病生存期为35个月；114例患者树干节点淋巴结转移，中位无病生存期为16个月；21例患者胸部近端淋巴结转移，中位无病生存期为15个月；26例患者树干节点和胸部近端均有淋巴结转移，中位无病生存期为8个月；而没有淋巴结转移的患者，其中位无病生存期为170个月。在多因素分析中，淋巴结转移的位置与生存独立相关。

结论：淋巴结转移灶的定位是生存的独立预测因子。因此，在以后应将淋巴结转移位置纳入食管和GEJ腺癌分期系统中。

原始出处：

Anderegg MC.et al.Prognostic Significance of the Location of Lymph Node Metastases in Patients With Adenocarcinoma of the Distal Esophagus or Gastroesophageal Junction.Ann Surg. 2016 Aug 4. [Epub ahead of print]

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    2017-02-10 yuhaisheng_ibp_32061711

    #食管腺#

    0

  2. 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    2016-09-04 ms6390871039024434

    #转移灶#

    0

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    2016-09-12 tastas

    #患者生存#

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 23 20:13:00 CST 2016, time=2016-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128450, encodeId=3188128450b5, content=不错哦，会学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 16 09:16:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=111595, encodeId=baa0111595ca, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, 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content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Aug 14 17:28:00 CST 2016, time=2016-08-14, status=1, ipAttribution=)]
    2016-09-23 1e10c84am36(暂无匿称)

    深度好文，值得学习

    0

  5. 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encodeId=a9fe102e2234, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d0ca1721548, createdName=WEIXIN8f086207, createdTime=Tue Aug 23 22:17:00 CST 2016, time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=98582, encodeId=f56398582c9, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Aug 14 17:29:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=98581, encodeId=bf0d9858102, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Aug 14 17:28:00 CST 2016, time=2016-08-14, status=1, ipAttribution=)]
    2016-09-16 1e10c84am36(暂无匿称)

    不错哦，会学到很多

    0

  6. 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encodeId=a9fe102e2234, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d0ca1721548, createdName=WEIXIN8f086207, createdTime=Tue Aug 23 22:17:00 CST 2016, time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=98582, encodeId=f56398582c9, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Aug 14 17:29:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=98581, encodeId=bf0d9858102, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Aug 14 17:28:00 CST 2016, time=2016-08-14, status=1, ipAttribution=)]
    2016-09-05 李东泽

    很好，不错，以后会多学习

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 23 20:13:00 CST 2016, time=2016-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128450, encodeId=3188128450b5, content=不错哦，会学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 16 09:16:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=111595, encodeId=baa0111595ca, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 05 16:47:00 CST 2016, time=2016-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104185, encodeId=c73010418568, content=深度好文，赞一个！!！, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Aug 26 09:04:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102722, encodeId=a9fe102e2234, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d0ca1721548, createdName=WEIXIN8f086207, createdTime=Tue Aug 23 22:17:00 CST 2016, time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=98582, encodeId=f56398582c9, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Aug 14 17:29:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=98581, encodeId=bf0d9858102, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Aug 14 17:28:00 CST 2016, time=2016-08-14, status=1, ipAttribution=)]
    2016-08-26 ylzr123

    深度好文，赞一个！!！

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1820997, encodeId=34a1182099eff, content=<a href='/topic/show?id=3488101119e7' target=_blank style='color:#2F92EE;'>#食管腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101119, encryptionId=3488101119e7, topicName=食管腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Fri Feb 10 19:28:00 CST 2017, time=2017-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1756552, encodeId=fcb11e56552ca, content=<a href='/topic/show?id=880d934525e' target=_blank style='color:#2F92EE;'>#转移灶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93452, encryptionId=880d934525e, topicName=转移灶)], attachment=null, authenticateStatus=null, createdAvatar=null, 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encodeId=a9fe102e2234, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d0ca1721548, createdName=WEIXIN8f086207, createdTime=Tue Aug 23 22:17:00 CST 2016, time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=98582, encodeId=f56398582c9, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Aug 14 17:29:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=98581, encodeId=bf0d9858102, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Aug 14 17:28:00 CST 2016, time=2016-08-14, status=1, ipAttribution=)]
    2016-08-23 WEIXIN8f086207

    继续关注

    0

  9. 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content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Aug 14 17:28:00 CST 2016, time=2016-08-14, status=1, ipAttribution=)]
    2016-08-14 doctorJiangchao

    继续关注

    0

  10. 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    2016-08-14 doctorJiangchao

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