Baidu
map

CGH:L-肉毒碱可减少肝硬化患者肌肉痉挛

2015-08-05 MedSci MedSci原创

根据一项研究发表在8月出版的《临床胃肠病学和肝脏病学》杂志表示,(每日健康)-左卡尼汀对减少肝硬化患者肌肉痉挛似乎是安全有效的。来自东京武藏野红十字医院的Hiroyuki Nakanishi和他的同事们前瞻性评估了左卡尼汀的效用(每天三次,每次300毫克(19名参与者)或每天四次(23名参与者)进行为期八周的实验),检测该剂量的左卡尼汀对肝硬化患者减少肌肉痉挛的作用。研究人员发现,在研究末期,所有

根据一项研究发表在8月出版的《临床胃肠病学和肝脏病学》杂志表示,(每日健康)-左卡尼汀对减少肝硬化患者肌肉痉挛似乎是安全有效的。


来自东京武藏野红十字医院的Hiroyuki Nakanishi和他的同事们前瞻性评估了左卡尼汀的效用(每天三次,每次300毫克(19名参与者)或每天四次(23名参与者)进行为期八周的实验),检测该剂量的左卡尼汀对肝硬化患者减少肌肉痉挛的作用。

研究人员发现,在研究末期,所有参与者的肌肉痉挛程度降低了88.1%,28.6%的病人肌肉痉挛现象已消失。总的来说,用直观模拟标度尺评估肌肉痉挛的程度从基线开始就显著降低(P < 0.0001)。服用更高剂量的左卡尼汀8周后能显著减少更大比例患者肌肉痉挛现象(43.5%,1200毫克/天剂量组比较10.5%,900毫克/天剂量组,P = 0.037)。研究结果没有不良事件发生。

“左卡尼汀的应用对治疗患肌肉痉挛的肝硬化患者可能是一个有前途的治疗方法。”作者写道

原始出处:
Nakanishi H, Kurosaki M, Tsuchiya K, Nakakuki N, Takada H, Matsuda S, Gondo K, Asano Y, Hattori N, Tamaki N, Suzuki S, Yasui Y, Hosokawa T, Itakura J, Takahashi Y, Izumi N.L-carnitine Reduces Muscle Cramps in Patients With Cirrhosis. Clin Gastroenterol Hepatol. 2015 Aug;13(8):1540-3 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2017912, encodeId=8a37201e912f6, content=<a href='/topic/show?id=1da38101150' target=_blank style='color:#2F92EE;'>#肌肉痉挛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81011, encryptionId=1da38101150, topicName=肌肉痉挛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ed25376, createdName=gdsun, createdTime=Wed Sep 02 04:41:00 CST 2015, time=2015-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058354, encodeId=d06f20583546f, content=<a href='/topic/show?id=f6ba4546d1' target=_blank style='color:#2F92EE;'>#CGH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4546, encryptionId=f6ba4546d1, topicName=CGH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, createdName=chendoc242, createdTime=Thu Mar 03 23:41:00 CST 2016, time=2016-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311735, encodeId=d0281311e3548, content=<a href='/topic/show?id=624de11204a' target=_blank style='color:#2F92EE;'>#痉挛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71120, encryptionId=624de11204a, topicName=痉挛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Fri Aug 07 14:41:00 CST 2015, time=2015-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35053, encodeId=06ba3505322, content=对目前研究提供了极大帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=208, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Thu Aug 06 22:50:00 CST 2015, time=2015-08-06, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2017912, encodeId=8a37201e912f6, content=<a href='/topic/show?id=1da38101150' target=_blank style='color:#2F92EE;'>#肌肉痉挛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81011, encryptionId=1da38101150, topicName=肌肉痉挛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ed25376, createdName=gdsun, createdTime=Wed Sep 02 04:41:00 CST 2015, time=2015-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058354, encodeId=d06f20583546f, content=<a href='/topic/show?id=f6ba4546d1' target=_blank style='color:#2F92EE;'>#CGH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4546, encryptionId=f6ba4546d1, topicName=CGH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, createdName=chendoc242, createdTime=Thu Mar 03 23:41:00 CST 2016, time=2016-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311735, encodeId=d0281311e3548, content=<a href='/topic/show?id=624de11204a' target=_blank style='color:#2F92EE;'>#痉挛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71120, encryptionId=624de11204a, topicName=痉挛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Fri Aug 07 14:41:00 CST 2015, time=2015-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35053, encodeId=06ba3505322, content=对目前研究提供了极大帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=208, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Thu Aug 06 22:50:00 CST 2015, time=2015-08-06, status=1, ipAttribution=)]
    2016-03-03 chendoc242
  3. [GetPortalCommentsPageByObjectIdResponse(id=2017912, encodeId=8a37201e912f6, content=<a href='/topic/show?id=1da38101150' target=_blank style='color:#2F92EE;'>#肌肉痉挛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81011, encryptionId=1da38101150, topicName=肌肉痉挛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ed25376, createdName=gdsun, createdTime=Wed Sep 02 04:41:00 CST 2015, time=2015-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058354, encodeId=d06f20583546f, content=<a href='/topic/show?id=f6ba4546d1' target=_blank style='color:#2F92EE;'>#CGH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4546, encryptionId=f6ba4546d1, topicName=CGH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, createdName=chendoc242, createdTime=Thu Mar 03 23:41:00 CST 2016, time=2016-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311735, encodeId=d0281311e3548, content=<a href='/topic/show?id=624de11204a' target=_blank style='color:#2F92EE;'>#痉挛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71120, encryptionId=624de11204a, topicName=痉挛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Fri Aug 07 14:41:00 CST 2015, time=2015-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35053, encodeId=06ba3505322, content=对目前研究提供了极大帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=208, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Thu Aug 06 22:50:00 CST 2015, time=2015-08-06, status=1, ipAttribution=)]
    2015-08-07 apoenzyme
  4. [GetPortalCommentsPageByObjectIdResponse(id=2017912, encodeId=8a37201e912f6, content=<a href='/topic/show?id=1da38101150' target=_blank style='color:#2F92EE;'>#肌肉痉挛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81011, encryptionId=1da38101150, topicName=肌肉痉挛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ed25376, createdName=gdsun, createdTime=Wed Sep 02 04:41:00 CST 2015, time=2015-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058354, encodeId=d06f20583546f, content=<a href='/topic/show?id=f6ba4546d1' target=_blank style='color:#2F92EE;'>#CGH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4546, encryptionId=f6ba4546d1, topicName=CGH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, createdName=chendoc242, createdTime=Thu Mar 03 23:41:00 CST 2016, time=2016-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311735, encodeId=d0281311e3548, content=<a href='/topic/show?id=624de11204a' target=_blank style='color:#2F92EE;'>#痉挛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71120, encryptionId=624de11204a, topicName=痉挛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Fri Aug 07 14:41:00 CST 2015, time=2015-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35053, encodeId=06ba3505322, content=对目前研究提供了极大帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=208, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Thu Aug 06 22:50:00 CST 2015, time=2015-08-06, status=1, ipAttribution=)]
    2015-08-06 hlycom3356

    对目前研究提供了极大帮助

    0

相关资讯

NEJM:红肉和鸡蛋可能增加患心脏病风险

几周之内,同一批研究者第二次报告:人们吃的食物和肠道内的细菌可能会提高心脏病风险。 两周前,他们说:基于肉毒碱——红肉中的一种物质——对肠道细菌的作用,它会让人更可能患心脏疾病。这一次,他们又称:蛋黄中大量存在的卵磷脂亦有同样效果。 这项卵磷脂研究发表在 4 月 24 日的《新英格兰医学杂志》(New England Journal of Medicine)上;它体现了人们对体内细菌是如何影响

Baidu
map
Baidu
map
Baidu
map