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BMJ:非创伤性颅内出血的影像诊断

2015-11-09 Seven L 译 MedSci原创

对非创伤性颅内出血患者,早期CT血管造影诊断准确度如何?该研究纳入了298名18-70岁患者,颅内出血7天内行CT血管造影,如果结果阴性,则在随后的4-8周行MRI/MRA检查,若MRI/MRA和CT造影结果不一致或均为阴性,则进行DSA检查。主要结局指标为大血管相关病因,包括动静脉畸形、动脉瘤、硬脑膜动静脉瘘、海绵状血管瘤 。3名神经学家根据影像资料独立评估造成出血的原因。研究过程中共有69(2

对非创伤性颅内出血患者,早期CT血管造影诊断准确度如何?

该研究纳入了298名18-70岁患者,颅内出血7天内行CT血管造影,如果结果阴性,则在随后的4-8周行MRI/MRA检查,若MRI/MRA和CT造影结果不一致或均为阴性,则进行DSA检查。主要结局指标为大血管相关病因,包括动静脉畸形、动脉瘤、硬脑膜动静脉瘘、海绵状血管瘤 。3名神经学家根据影像资料独立评估造成出血的原因。

研究过程中共有69(23%)名患者发现了大血管病因。291(98%)名患者行CT造影,214名患者结果阴性行MRI/MRA检查,97名两项检查结果均阴性行DSA检查。

早期CT血管造影检测到51例大血管病因(诊断阳性率 17%, 95% CI 13% - 22%)。CT造影+MRI/MRA发现了另外2例(18%, 14% - 23%)。CT造影+MRI/MRA+DSA发现了另外15例 (23%, 18% - 28%)。不过CT造影+MRI/MRA+DSA该种组合未能发现海绵状血管瘤,在随后的随访中通过MRI得以发现。

CT血管造影的阳性预测值为72% (60% - 82%),CT造影+MRI/MRA该值为35% (14% - 62%),CT造影+MRI/MRA+DSA该值为100% (75% - 100%)。没有发现与CT血管造影或MRI/MRA相关的并发症,不过有0.6%的行DSA患者发生了永久性的后遗症。并不是所有的CT造影+MRI/MRA阴性结果患者均行了DSA。在行DSA检查之前,大血管导致出血原因发现率很低,可能会漏掉一些小动静脉畸形或硬脑膜动静脉瘘。

研究结果表明,对非创伤性颅内出血患者,CT血管造影可用于初步探查大血管出血原因,虽然精确度居中。在此基础上使用MRI/MRA可以发现海绵状瘤或其他诊断,不过对CT造影和MRI/MRA阴性的患者,有必要行DSA检查。

原始出处:


Charlotte J J van Asch, Birgitta K Velthuis,et al.Diagnostic yield and accuracy of CT angiography, MR angiography, and digital subtraction angiography for detection of macrovascular causes of intracerebral haemorrhage: prospective, multicentre cohort study.BMJ 2015;351:h5762


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  1. [GetPortalCommentsPageByObjectIdResponse(id=1847749, encodeId=066d184e74998, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sat Jan 09 03:52:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=107750, encodeId=a04a10e75082, content=这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Aug 30 23:00:00 CST 2016, time=2016-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025425, encodeId=3e81202542519, content=<a href='/topic/show?id=66f93204223' target=_blank style='color:#2F92EE;'>#创伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32042, encryptionId=66f93204223, topicName=创伤性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Fri Apr 08 18:52:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335088, encodeId=e45f13350888a, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Wed Nov 11 13:52:00 CST 2015, time=2015-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445579, encodeId=ece214455e9d5, content=<a href='/topic/show?id=643e5031124' target=_blank style='color:#2F92EE;'>#影像诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50311, encryptionId=643e5031124, topicName=影像诊断)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erGh2JQt8g9L1dqpdLyJ7EDClYbBfjvngmKJ6Vn8jCDHuYvHH6ZLao7bSXVr4okhjNU9ojr0SZFxQ/132, createdBy=12ec5143276, createdName=12498fa0m12暂无昵称, createdTime=Wed Nov 11 13:52:00 CST 2015, time=2015-11-11, status=1, ipAttribution=)]
    2016-01-09 gaoxiaoe
  2. [GetPortalCommentsPageByObjectIdResponse(id=1847749, encodeId=066d184e74998, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sat Jan 09 03:52:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=107750, encodeId=a04a10e75082, content=这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Aug 30 23:00:00 CST 2016, time=2016-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025425, encodeId=3e81202542519, content=<a href='/topic/show?id=66f93204223' target=_blank style='color:#2F92EE;'>#创伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32042, encryptionId=66f93204223, topicName=创伤性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Fri Apr 08 18:52:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335088, encodeId=e45f13350888a, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Wed Nov 11 13:52:00 CST 2015, time=2015-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445579, encodeId=ece214455e9d5, content=<a href='/topic/show?id=643e5031124' target=_blank style='color:#2F92EE;'>#影像诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50311, encryptionId=643e5031124, topicName=影像诊断)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erGh2JQt8g9L1dqpdLyJ7EDClYbBfjvngmKJ6Vn8jCDHuYvHH6ZLao7bSXVr4okhjNU9ojr0SZFxQ/132, createdBy=12ec5143276, createdName=12498fa0m12暂无昵称, createdTime=Wed Nov 11 13:52:00 CST 2015, time=2015-11-11, status=1, ipAttribution=)]
    2016-08-30 李东泽

    这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1847749, encodeId=066d184e74998, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sat Jan 09 03:52:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=107750, encodeId=a04a10e75082, content=这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Aug 30 23:00:00 CST 2016, time=2016-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025425, encodeId=3e81202542519, content=<a href='/topic/show?id=66f93204223' target=_blank style='color:#2F92EE;'>#创伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32042, encryptionId=66f93204223, topicName=创伤性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Fri Apr 08 18:52:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335088, encodeId=e45f13350888a, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Wed Nov 11 13:52:00 CST 2015, time=2015-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445579, encodeId=ece214455e9d5, content=<a href='/topic/show?id=643e5031124' target=_blank style='color:#2F92EE;'>#影像诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50311, encryptionId=643e5031124, topicName=影像诊断)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erGh2JQt8g9L1dqpdLyJ7EDClYbBfjvngmKJ6Vn8jCDHuYvHH6ZLao7bSXVr4okhjNU9ojr0SZFxQ/132, createdBy=12ec5143276, createdName=12498fa0m12暂无昵称, createdTime=Wed Nov 11 13:52:00 CST 2015, time=2015-11-11, status=1, ipAttribution=)]
    2016-04-08 amyloid
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