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Diabetologia:出生季节可能预示着你有更高几率患成人2型糖尿病!

2017-05-18 石岩 环球医学

2017年5月,发表在《Diabetologia》的一项由中国科学家进行的针对50万中国成年人的前瞻性队列研究,得出了出生季节与患成人2型糖尿病的风险相关的结论。目的/假设:出生季节作为胎儿发育和早期出生后生活中潜在的环境暴露,已经显示出与住在高纬度地区的白种人群中成人2型糖尿病的非一致的相关性。当前研究旨在考察居住在低纬度~低至中纬度区域的中国人中,出生季节性与成人2型糖尿病风险之间的相关性。方

2017年5月,发表在《Diabetologia》的一项由中国科学家进行的针对50万中国成年人的前瞻性队列研究,得出了出生季节与患成人2型糖尿病的风险相关的结论。

目的/假设:出生季节作为胎儿发育和早期出生后生活中潜在的环境暴露,已经显示出与住在高纬度地区的白种人群中成人2型糖尿病的非一致的相关性。当前研究旨在考察居住在低纬度~低至中纬度区域的中国人中,出生季节性与成人2型糖尿病风险之间的相关性。

方法:研究对象是来自于2004~2008年间在China Kadoorie Biobank登记的人,且随访截至2013年12月31日。在基线排除癌症、心脏病、卒中和糖尿病患者后,当前研究纳入男性189153人和女性272058人,年龄在30~79岁。研究人员用多变量Cox比例风险模型评估HR和95%CI。

结果:在中位随访7.2年(3.30百万人-年)期间,研究人员记录了8784例2型糖尿病病例。在整个队列中,与夏天出生的研究对象相比,春天、秋天和冬天出生的研究对象的调整HR(95% CIs)分别为1.09(1.02,1.16)、1.08(1.02,1.15)和1.09(1.02,1.15)。这种相关性在男性和女性中一致,在后来生活的住处和生活方式因素定义的亚组中也一致。

结论/解释:在本项大型、前瞻性研究中,出生在夏天的研究对象比出生在其他季节的研究对象患成人2型糖尿病的风险低,表明幼年一定程度的季节变异性暴露可能影响患成人糖尿病风险。

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    2017-06-09 jyzxjiangqin

    积极防治2型糖尿病。

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Thu Jun 08 13:37:12 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201908, encodeId=93bd201908b4, content=2型糖尿病发病机制。, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed May 24 07:24:39 CST 2017, time=2017-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201486, encodeId=14fc201486bd, content=好文章,好思路, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Tue May 23 06:25:35 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1303001, encodeId=8d60130300189, content=<a href='/topic/show?id=db455381944' target=_blank style='color:#2F92EE;'>#成人2型糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53819, encryptionId=db455381944, topicName=成人2型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=65c7309, createdName=fengxx, createdTime=Sat May 20 07:09:00 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468667, encodeId=58ca146866e18, content=<a href='/topic/show?id=a19b4540688' target=_blank style='color:#2F92EE;'>#季节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45406, encryptionId=a19b4540688, topicName=季节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cf986929326, createdName=30397606, createdTime=Sat May 20 07:09:00 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200103, encodeId=c9d120010363, content=不错的方式,努力学习,刻苦专研,不断总结出来新经验。, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri May 19 20:16:14 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199940, encodeId=b35519994083, content=学习了谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Fri May 19 10:12:31 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
    2017-06-08 I come

    学习了谢谢分享

    0

  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199940, encodeId=b35519994083, content=学习了谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Fri May 19 10:12:31 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
    2017-05-24 jyzxjiangqin

    2型糖尿病发病机制。

    0

  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199940, encodeId=b35519994083, content=学习了谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Fri May 19 10:12:31 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
    2017-05-23 I come

    好文章,好思路

    0

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  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199940, encodeId=b35519994083, content=学习了谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Fri May 19 10:12:31 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
    2017-05-20 30397606
  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199940, encodeId=b35519994083, content=学习了谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Fri May 19 10:12:31 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
    2017-05-19 虈亣靌

    不错的方式,努力学习,刻苦专研,不断总结出来新经验。

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199940, encodeId=b35519994083, content=学习了谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Fri May 19 10:12:31 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
    2017-05-19 186****0580(小山羊)

    学习了谢谢了。

    0

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超重或肥胖的2型糖尿病患者大脑和认知结构更可能发生恶化和进行性异常。

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在这项回顾性研究中,研究人员发现纤维化分期为3-4期的患者比纤维化分期为0-2期的患者发生2型糖尿病的比例更高。在纤维化分期为0-2期的患者中,脂肪评分与2型糖尿病的发生风险相关。

Diabetes Care:2型糖尿病的血糖控制:CSII vs MDI

2017年5月,发表在《Diabetes Care》的一项由英国科学家进行的随机对照试验的个体患者数据Meta分析和Meta回归,比较了持续皮下胰岛素输注(CSII)和每日多次胰岛素注射(MDI)的血糖控制。目的:比较2型糖尿病患者在CSII和MDI期间的血糖控制,来确定采用CSII治疗更有效的患者的特质。研究设计方法:选定随机对照试验,比较2型糖尿病人群中CSII vs MDI治疗期间的HbA1

Diabetes Obes Metab:2型糖尿病老年患者:这一二线方案不仅能降低结局风险且物超所值

对于需要从二甲双胍单药疗法升级的2型糖尿病老年患者,哪种二线方案更为有效且经济。2017年5月,发表在《Diabetes Obes Metab》的一项回顾性、基于初级护理的队列研究显示,目前研究的数据支持处方二甲双胍+SU作为替代方案,能降低结局风险且物超所值。

Diabetes Care:预防2型糖尿病的国家努力效果如何?

由此可见,在计划实施头4年里,国家DPP已被广泛采用生活方式改变计划来预防2型糖尿病,并且有前景较好的早期结果。更长的参会持续时间和强度可导致较高的整体和亚群的体重减轻。

Diabetes Obes Metab:2型糖尿病:要想列净类安全有效 要控制碳水化合物摄入

2017年5月,发表在《Diabetes Obes Metab》的一项由日本科学家进行的随机、开放标签、3组平行比较、探索性研究,考察了日本2型糖尿病(T2D)个体使用钠-葡萄糖协同转运蛋白2(SGLT2)抑制剂与膳食中碳水化合物的摄入的相关性。该研究考察了日本T2DM个体使用SGLT2抑制剂列净与摄入不同碳水化合物的安全性和有效性。受试者被随机分配至3个碳水化合物调整饮食组,为期14天(第1~1

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