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Eur Respir J:从不吸烟者肺癌体细胞突变与职业暴露有何关系?

2017-10-26 xing.T MedSci原创

鉴于职业暴露在亚群中的最小作用,研究人员得出结论:即职业暴露对从不吸烟的肺癌患者分子模式影响十分轻微。特别是石棉暴露的参与者EGFR突变的几率很低。

职业暴露是肺癌常见的危险因素。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员观察到73%的从未吸烟者发生了分子改变,35%的男性和8%的妇女至少暴露在一种职业致癌物中。在这项研究中,研究人员报告分子模式和职业暴露之间的关系。

BioCAST是在从不吸烟者的肺癌患者中进行的队列研究,这些受试者报告了暴露的危险因素与分子模式。职业暴露是通过验证的71项调查问卷来进行评估的。患者被分为未暴露组和暴露于多环芳香烃(PAH)、石棉、石英、柴油废气(DEF)、铬和油漆组。检查结果记录了EGFR、KRAS、HER2、BRAF和PIK3突变和ALK改变。

总体而言,研究人员对纳入BioCAST研究的384例患者中的313例患者进行分析。石棉暴露患者的EGFR突变率显著降低(20% vs. 44%,P=0.033),而HER2突变率较高(18% vs. 4%,P=0.084)。ALK改变与任何职业性致癌物并不相关。DEF暴露患者中的25%病例被诊断存在BRAF突变。铬暴露患者表现出HER2和PIK3突变频率增加。

鉴于职业暴露在亚群中的最小作用,研究人员得出结论:即职业暴露对从不吸烟的肺癌患者分子模式影响十分轻微。特别是石棉暴露的参与者EGFR突变的几率很低。

原始出处:


Christophe Paris, et al. Association between lung cancer somatic mutations and occupational exposure in never-smokers. Eur Respir J. 2017. http://erj.ersjournals.com/content/50/4/1700716

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    2017-11-01 yfjms

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    2017-10-28 方舒

    学习

    0

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