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Hum Reprod Update:所谓痛经

2015-10-29 candy 译 MedSci原创

背景:在没有盆腔病理学之前,痛经是普遍的,是往往令人衰弱的妇科疾病,影响了大概45%-95%之间的行经后女性。通过对专业医务人员、疼痛研究人员和女性的调查发现,尽管痛经如此高发,却常常是治疗不好的,甚至是被忽视的。大多数女性认为痛经是正常月经周期的一部分。本次回顾报告目前的知识,特别是关于复发性痛经的疼痛敏感性、情绪、生活质量和原发性痛经女性的睡眠。方法:使用PubMed、谷歌学者和Cochran

背景:在没有盆腔病理学之前,痛经是普遍的,是使人衰弱的妇科疾病,影响了大概45%-95%的行经期女性。通过对专业医务人员、疼痛研究人员和女性的调查发现,尽管痛经如此高发,却常常是治疗效果满意度较差,甚至是被忽视的。大多数女性认为痛经是正常月经周期的一部分。本次回顾性报告目前的知识,特别是关于复发性痛经的疼痛敏感性、情绪、生活质量和原发性痛经女性的睡眠情况。

方法:使用PubMed、谷歌学者和Cochrane Library数据库,综合性检索关于原发性痛经的文献。对在2015和1944年之间发表的全文手稿进行了相关性审查,另外对参考文献列表进行交叉检查,以增加相关性研究。使用单个“痛经”一词,并与下面的检索词结合,在同学科期刊上获取已发表的文章:痛苦、危险因素、病因、临床实验性疼痛、疼痛、子宫腺肌病、慢性疼痛、女性、月经周期、痛觉过敏、疼痛阈值、疼痛耐受、疼痛敏感、疼痛反应、疼痛的感知、中枢致敏、生活质量、睡眠、治疗、非甾体类抗炎药。

结果:有痛经的女性较无痛经的女性有更大的实验性疼痛的敏感性,无论疼痛是否是痛经引起的。重要的是,当女性没有经历过痛经,这种疼痛感的增强会在月经周期中更明显,说明疼痛的长期性差异延长了月经期之外的痛苦。这种增强的疼痛敏感性可能在以后的生活中会增加其他的慢性疼痛条件;另外发现痛经是纤维肌痛症的一个危险因素。此外,因为每个月的几天痛经,对生活质量有直接的负面影响。有原发性痛经的女性患者相较其他无疼痛的卵泡期和无痛经女性组成的对照组,其经期的生活质量明显降低,月经期间的睡眠质量较差。治疗痛经的常规一线药仍然是非甾体类抗炎药,它可以有效缓解白天和夜间的疼痛。

结论:需要进一步的研究来确定是否能通过有效阻断痛经以改善今后慢性疼痛性疾病发展的风险,和探讨是否可以预防痛经的发展,而不仅仅是治疗严重的少女痛经。总之,研究人员证明了广泛的多因素对痛经的影响,并鼓励和引导研究者在未来进行必要的研究。

原始出处:


Iacovides S, Avidon I, Baker FC.What we know about primary dysmenorrhea today: a critical review.Hum Reprod Update. 2015 Nov;21(6):762-78. 

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1796603, encodeId=45971e96603cc, content=<a href='/topic/show?id=6f28181514b' target=_blank style='color:#2F92EE;'>#Update#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18151, encryptionId=6f28181514b, topicName=Update)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7482500171, createdName=ms4468361851264128, createdTime=Fri Jun 10 17:06:00 CST 2016, time=2016-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46548, encodeId=08f8465485b, content=作者的延展性和发散性思维真广,细心。, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Dec 17 23:40:00 CST 2015, time=2015-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46547, encodeId=47874654e75, content=看到一生殖中心报道说止痛药吃多了可能会损害卵巢功能, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Dec 17 23:39:00 CST 2015, time=2015-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601765, encodeId=acb21601e65af, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat Oct 31 12:06:00 CST 2015, time=2015-10-31, status=1, ipAttribution=)]
    2015-12-17 cmn

    作者的延展性和发散性思维真广,细心。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1796603, encodeId=45971e96603cc, content=<a href='/topic/show?id=6f28181514b' target=_blank style='color:#2F92EE;'>#Update#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18151, encryptionId=6f28181514b, topicName=Update)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7482500171, createdName=ms4468361851264128, createdTime=Fri Jun 10 17:06:00 CST 2016, time=2016-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46548, encodeId=08f8465485b, content=作者的延展性和发散性思维真广,细心。, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Dec 17 23:40:00 CST 2015, time=2015-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46547, encodeId=47874654e75, content=看到一生殖中心报道说止痛药吃多了可能会损害卵巢功能, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Dec 17 23:39:00 CST 2015, time=2015-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601765, encodeId=acb21601e65af, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat Oct 31 12:06:00 CST 2015, time=2015-10-31, status=1, ipAttribution=)]
    2015-12-17 cmn

    看到一生殖中心报道说止痛药吃多了可能会损害卵巢功能

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1796603, encodeId=45971e96603cc, content=<a href='/topic/show?id=6f28181514b' target=_blank style='color:#2F92EE;'>#Update#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18151, encryptionId=6f28181514b, topicName=Update)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7482500171, createdName=ms4468361851264128, createdTime=Fri Jun 10 17:06:00 CST 2016, time=2016-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46548, encodeId=08f8465485b, content=作者的延展性和发散性思维真广,细心。, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Dec 17 23:40:00 CST 2015, time=2015-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46547, encodeId=47874654e75, content=看到一生殖中心报道说止痛药吃多了可能会损害卵巢功能, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Dec 17 23:39:00 CST 2015, time=2015-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601765, encodeId=acb21601e65af, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat Oct 31 12:06:00 CST 2015, time=2015-10-31, status=1, ipAttribution=)]
    2015-10-31 柳叶一刀

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